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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 3 | Low temperature hydrogenation of benzene and cyclohexene:A comparativestudy between γ-Al2O3 supported Pt-Co and Pt-Ni bimetallic catalysts显示文摘 | Lu S L Lonergan W W Bosco J P | | 0，，259： | 1 |
| 4 | Lens fiber transdifferen-tiation in cultured larval Xenopus leavis out cornea under the influence of neural retina-conditioned medium 显示文摘 | Bosco L Testa O Venturini G Willems D | 1997 | Cell Mol Life Sci1997，53，1112： | 1 |
| 5 | Neurokinin 1 receptor expression and substance P physiological actions are developmentally regulated in the rabbit retina显示文摘 | Casini G Dal Monte M Fornai F Bosco L Willems D Yang Q | 2004 | Neuroscience2004，124，1： | 1 |
| 6 | Dendritic cell reprogramming by the hypoxic environment 显示文摘 | Bosco MC Varesio L | 2012 | Immunobiology2012，217，12： | 1 |
| 7 | Effect of dietary α- linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | Dal Bosco A Castellini C Bianchl L | 2004 | Meat Sci2004，66，： | 1 |
| 8 | Is there a crossroad be- tween infections, genetics, and Henoch-SchiJnlein purpura? 显示文摘 | Rigante D Castellazzi L Bosco A | 2013 | Autoimmun Rev2013，12，10： | 1 |
| 9 | Telomere maintenance is dependent on activities required for end repair of double-strand breaks显示文摘 | Nugent C I Bosco G Ross L O | 1998 | Curr Biol1998，8，11： | 1 |
| 10 | Effect of dietary a-linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | dal BOSCO A CASTELLINI C BIANCHI L | 2004 | Meat Science2004，66，2： | 1 |
| 11 | Polysaccharides from hot water extracts of roasted coffea arabica beans : isolation and characterization显示文摘 | Navarini L Gilli R Gombac V Abatangelo A Bosco M Toffanin R | 1999 | Carbohydrate Polymers1999，40，： | 1 |
| 12 | Accumulative effects in temporal coherent control显示文摘 | FELINTO D BOSCO C A C ACIOLI L H | 2001 | Phys Rev A2001，64，06： | 1 |
| 13 | Evolution of the wide area network显示文摘 | | 2000 | Bell Labs Technical Journal2000，5，1： | 1 |
| 14 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing homone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 15 | Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis显示文摘 | Kwiatkowski TJ Bosco DA LeClerc L | | 0，，5918： | 1 |
| 16 | Use of a multicomponent,recombinant,meningococcal serogroup B vaccine(4CMen B)for bacterial meningitis prevention显示文摘 | Esposito SC astellazzi L Bosco A | 2014 | Immunotherapy2014，6，4： | 1 |
| 17 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 18 | Lower apoptosis rate in humancumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures 显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steri12007，87，3： | 1 |
| 19 | Sea urchin embryos exposed to cadmium as an experimental model for studying the relationship between autophagy and apoptosis显示文摘 | Chiarelli R Agnello M Bosco L | 2014 | Marine Environmental Research2014，93，： | 1 |
| 20 | Increased hepatic expression of insulin-like growth factor-Ⅰreceptor in chronic hepatitis C显示文摘瞄准:尽管增加像胰岛素的生长因素 -- 我受体(IGF 红外) 基因表示在肝细胞癌被报导了,在长期的丙肝(CHC ) 估计 IGF 红外的研究和肝硬化是少见的。我们因此试图与 CHC 从病人在肝评估 IGF 红外和 IGF-I mRNA 表示。方法:IGF 红外和 IGF-I mRNA 内容被半量的 RT-PCR 决定, IGF 红外蛋白质表示由在以前与 CHC 从病人获得的肝的织物(34 个病人) 并且在以后的 immunohisto 化学是坚定的(10 个病人) 有 interferon-alpha 和 ribavirin 的治疗。结果:IGF 红外 mRNA 内容的增加在从所有 CHC 病人以及从与正常的肝相比跟随 orthopic 移植(评估正常的肝的一次尝试) 的 6 个尸体肝施主获得的肝的织物被观察,当没有相关修正在 IGF-I mRNA 内容被检测时。组织化学的结果显示出的免疫在 IGF 红外 mRNA 的加薪满足,这与 ductular 反应并且到在 hepatocytes 的增加的 IGF 红外表示相关。在 IGF 红外 mRNA 内容的减少在在治疗以后完成了持续 virological 反应的病人被观察,建议处于肝的损坏的改进。结论:在有 CHC 的病人的 hepatocytes 的 IGF 红外表示的起来规定能组成一次尝试刺激 hepatocyte 新生。考虑到那个肝是有 IGF-I 的高水平的机关,我们在尖锐、长期的肝的损坏以后发现增加的 IGF 红外表示加亮需要让另外的研究阐明在肝的 IGF-I 的角色新生。 | José Tadeu Stefano Maria Lúcia Corr(e|^)a-Giannella Cristiane Maria Freitas Ribeiro Ven(a|^)ncio Avancini Ferreira Alves Paulo Celso Bosco Massarollo Marcel Cerqueira Cesar Machado Daniel Giannella-Neto | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
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