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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | Virtual experimentation through 3D full-loop simulation of a circulating fluidized bed显示文摘Eulerian granular multiphase model with a drag coefficient correction based on the energy-minimization multi-scale (EMMS) model was used to simulate a semi-industry scale circulating fluidized bed (CFB). Three-dimensional (3D), time-dependent simulation of a full-loop CFB revealed that the axial profiles of cross-sectionally averaged solid volume fraction, and the radial profiles of solid axial velocity and solid volume fraction were in reasonable agreement with experimental data. Based on this agreement, database derived from experiments not yet accomplished was replenished with such simulations, and fluid regime diagrams and pressure balance around the CFB loop were derived accordingly. This work presents an integrated viewpoint on CFB and unfolds a fresh paradigm for CFB modeling, which can be expected to help resolve certain issues long in dispute but hard for experiments. | Nan Zhang Bona Lu Wei Wang Jinghai Li | 2008 | Particuology2008，6，6： | 23 |
| 3 | 基于SP调查的天津市居民出行行为时间价值显示文摘为揭示天津市居民出行行为时间价值的一般规律,采用SP调查中的卡片式面谈调查法,运用市场细分法确定调查规模及抽样率,采用计算包容性检查矩阵等数据处理手段,估算天津市居民出行行为时间价值。比较了出行行为时间价值与单位工作时间价值之间的关系,并分析了不同出行方式、出行目的、出行时段的时间价值,研究了出行收入与时间价值的变化规律。得出现阶段天津市居民出行行为时间价值的分布,表明大部分出行者不愿为出行支付较高费用,但随着收入增加,出行行为时间价值将会快速增长,使个体机动化出行方式的需求增大,城市出行方式结构可能出现拐点。 | 蒋寅 李彤 Richard F.Di Bona | 2009 | 城市交通2009，7，2： | 14 |
| 4 | Bisacodyl plus split 2-L polyethylene glycol-citrate-simethicone improves quality of bowel preparation before screening colonoscopy显示文摘AIM:To compare the bowel cleansing efficacy,tolerability and acceptability of split 2-L polyethylene glycol(PEG)-citrate-simethicone(PEG-CS)plus bisacodyl(BIS)vs 4-L PEG for fecal occult blood test-positive screening colonoscopy.METHODS:This was a randomised,observer-blind comparative study.Two hundred and sixty-four subjects underwent screening colonoscopy(mean age 62.5±7.4years,male 61.7%).The primary objective of the study was to compare the bowel cleansing efficacy of the two preparations.Interventions:BIS plus PEG-CS:3 tablets of 5-mg BIS at 16:00,PEG-CS 1-L at 19:00 and 1-L at7:00,4-L PEG:3-L at 17:00,and 1-L at 7:00.Colonoscopy was carried out after 11:00,at least 3 h after the completion of bowel preparation.Bowel cleansing was evaluated using the Harefield Cleansing Scale.RESULTS:Bowel preparation was successful for 92.8%of subjects in the PEG-CS group and for 92.1%of subjects in the 4-L PEG(RR=1.01;95%CI:0.94-1.08).BIS+PEG-CS was better tolerated than 4-L PEG.A greater rate of patients in the BIS+PEG-CS group had no difficulty and/or were willing to repeat the same preparation compared to split-dose 4-L PEG group.Subjects in the BIS+PEG-CS group rated the prep as good or satisfactory in 90.6%as compared to 77%in the 4-L PEG(P=0.003).Subjects receiving BIS+PEGCS stated they fully adhered to instructions drinking all the 2-L solution in 97.1%compared with 87.3%in the4-L PEG(P=0.003).CONCLUSION:BIS plus split 2-L PEG-CS was as effective as but better tolerated and accepted than split4-L PEG for screening colonoscopy.This new procedure may increase the positive attitude and participation to colorectal cancer screening colonoscopy. | Flavio Valiante Angelo Bellumat Manuela De Bona Michele De Boni | 2013 | World Journal of Gastroenterology2013，19，33： | 10 |
| 5 | Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma:Review of the literature显示文摘Cholangiocarcinoma(CCA)is a malignant tumor of the biliary system and includes,according to the anatomical classification,intra hepatic CCA(iCCA),hilar CCA(hCCA)and distal CCA(dCCA).Hilar CCA is the most challenging type in terms of diagnosis,treatment and prognosis.Surgery is the only treatment possibly providing long-term survival,but only few patients are considered resectable at the time of diagnosis.In fact,tumor’s extension to segmentary or subsegmentary biliary ducts,along with large lymph node involvement or intrahepatic metastases,precludes the surgical approach.To achieve R0 margins is mandatory for the disease-free survival and overall survival.In case of unresectable locally advanced hCCA,radiochemotherapy(RCT)as neoadjuvant treatment demonstrated to be a therapeutic option before either hepatic resection or liver transplantation.Before liver surgery,RCT is believed to enhance the R0 margins rate.For patients meeting the Mayo Clinic criteria,RCT prior to orthotopic liver transplant(OLT)has proved to produce acceptable 5-years survivals.In this review,we analyze the current role of neoadjuvant RCT before resection as well as before OLT. | Fabio Frosio Federico Mocchegiani Grazia Conte Enrico Dalla Bona ANDrea Vecchi Daniele Nicolini Marco Vivarelli | 2019 | World Journal of Gastrointestinal Surgery2019，11，6： | 7 |
| 6 | Synthesis of chain-like MoS_2 nanoparticles in W/O reverse microemulsion and application in photocatalysis显示文摘Chain-like MoS2assemblies consisting of hexagonal MoS2nanoparticles(20-60 nm) have been successfully synthesized in a Triton X-100/cyclohexane/hexanol/water W/O reverse microemulsion in the presence of(NH 4)2MoS 4 as the molybdenum source and NH2OH·HCl as the reducing agent.The products were characterized by X-ray powder diffraction(XRD),transmission electron microscopy(TEM) and UV-vis diffuse reflectance absorption spectra.The influence of synthetic parameters such as acidity,water/oil ratio(0),aging time and annealing temperature on the formation of MoS2assemblies was investigated.TEM analysis showed that these synthetic factors played important roles in controlling the size of MoS2nanoparticles and the length of the chain-like MoS2assemblies.XRD analysis indicated that the well-crystallized MoS2nanoparticles could be obtained by annealing the precursors at 700 C for2h under a flow of N2atmosphere.In addition,the as-prepared chain-like MoS2nanoparticles exhibited excellent photocatalytic H2activity in Ru(bpy) 3 2+-MoS2-H2A three-component molecular systems under visible light irradiation. | LIU MeiYing LI XiaoQian XU ZhiLing LI BoNa CHEN LinLin SHAN NanNan | 2012 | Chinese Science Bulletin2012，57，30： | 6 |
| 7 | Numerical comparison of two modes of gas-solid riser operation: Fluid catalytic cracking vs CFB combustor显示文摘 | Yifeng Mei Mingzhao Zhao Bona Lu Sheng Chen Wei Wang | 2017 | Particuology2017，15，2： | 4 |
| 8 | Extending EMMS-based models to CFB boiler applications显示文摘Recently,EMMS-based models are being widely applied in simulations of high-throughput circulating fluidized beds(CFBs) with fine particles.Its use for low flux systems,such as CFB boiler(CFBB),still remains unexplored.In this work,it has been found that the original definition of cluster diameter in EMMS model is unsuitable for simulations of the CFB boiler with low solids flux.To remedy this,we propose a new model of cluster diameter.The EMMS-based drag model(EMMS/matrix model) with this revised cluster definition is validated through the computational fluid dynamics(CFD) simulation of a CFB boiler. | Bona Lu Nan Zhang Wei Wang Jinghai Li | 2012 | Particuology2012，10，6： | 4 |
| 9 | Long-term results of endosurgical and open surgical approach for Zenker diverticulum显示文摘AIM: To assess the effectiveness of minimally invasive versus traditional open surgical approach in the treatment of Zenker diverticulum. METHODS: Between 1976 and 2006, 297 patients underwent transoral stapling (n = 181) or stapled diverticulectomy and cricopharyngeal myotomy (n = 116). Subjective and objective evaluations of the outcome of the two procedures were made at 1 and 6 mo after operation, and then every year. Long-term follow-up data were available for a subgroup of patients at a minimum of 5 and 10 years. RESULTS: The operative time and hospital stay were markedly reduced in patients undergoing the endosurgical approach. Overall, 92% of patients undergoing the endosurgical approach and 94% of those undergoing the open approach were symptom-free or were significantly improved after a median follow-up of 27 and 48 mo, respectively. At a minimum follow-up of 5 and 10 years, most patients were asymptomatic after both procedures, except for those individuals undergoing an endosurgical procedure for a small diverticulum (< 3 cm). CONCLUSION: Both operations relieve the outflow obstruction at the pharyngoesophageal junction, indicating that cricopharyngeal myotomy has an important therapeutic role in this disease independent of the resection of the pouch and of the surgical approach. Diverticula smaller than 3 cm represent a formal contraindication to the endosurgical approach because the common wall is too short to accommodate one cartridge of staples and to allow complete division of the sphincter. | Luigi Bonavina Davide Bona Medhanie Abraham Greta Saino Emmanuele Abate | 2007 | World Journal of Gastroenterology2007，13，18： | 4 |
| 10 | Extending the EMMS/bubbling model to fluidization of binary particle mixture: Formulation and steady-state validation显示文摘The EMMS/bubbling model originally proposed for fluidization of monodisperse particles is extended to fluidization of binary particle mixture in this study.The dense and dilute phases are considered to comprise of two types of particles differing in size and/or density.Governing equations and the stability condition are then formulated and solved by using an optimization numerical scheme.The effects of bubble diameter are first investigated and a suitable bubble diameter correlation is chosen.Preliminary validation for steady state behavior shows the extended model can fairly capture the overall hydrodynamic behaviors in terms of volume fraction of bubbles and average bed voidage for both monodisperse and binary particle systems.This encourages us to integrate this model with CFD for more validations in the future. | Nouman Ahmad Yujie Tian Bona Lu Kun Hong Haifeng Wang Wei Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 2 |
| 11 | A comparison of root characteristics in relation to nutrient and water stress in two maize hybrids显示文摘 | T. Vamerali M. Saccomani S. Bona G. Mosca M. Guarise A. Ganis | 2003 | Plant and Soil2003，，1： | 2 |
| 12 | A randomized controlled trial evaluating a new 2-L PEG solution plus ascorbic acid vs 4-L PEG for bowel cleansing prior to colonoscopy显示文摘 | Flavio Valiante Stefano Pontone Cesare Hassan Angelo Bellumat Manuela De Bona Angelo Zullo Vincenzo de Francesco Michele De Boni | 2011 | Digestive and Liver Disease2011，，3： | 2 |
| 13 | Laparoscopic Rectal Resection for Cancer: Effects of Conversion on Short-Term Outcome and Survival显示文摘 | Matteo Rottoli Stefano Bona Riccardo Rosati Ugo Elmore Paolo P. Bianchi Antonino Spinelli Cristina Bartolucci Marco Montorsi | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 14 | Covered nitinol stents for the treatment of esophageal strictures and leaks显示文摘AIM:To compare 2 different types of covered esophageal nitinol stents(Ultraflex and Choostent) in terms of efficacy,complications,and long-term outcome.METHODS:A retrospective review of a consecutive series of 65 patients who underwent endoscopic placement of an Ultraflex stent(n = 33) or a Choostent(n = 32) from June 2001 to October 2009 was conducted.RESULTS:Stent placement was successful in all patients without hospital mortality.No significant differences in patient discomfort and complications were observed between the Ultraflex stent and Choostent groups.The median follow-up time was 6 mo(interquartile range 3-16 mo).Endoscopic reintervention was required in 9 patients(14%) because of stent migration or food obstruction.No significant difference in the rate of reintervention between the 2 groups was observed(P = 0.8).The mean dysphagia score 1 mo after stent placement was 1.9 ± 0.3 for the Ultraflex stent and 2.1 ± 0.4 for the Choostent(P = 0.6).At 1-mo follow-up endoscopy,the cover membrane of the stent appeared to be damaged more frequently in the Choostent group(P = 0.34).Removal of the Choostent was possible up to 8 wk without difficulty.CONCLUSION:Ultraflex and Choostent proved to be equally reliable for palliation of dysphagia and leaks.Removal of the Choostent was easy and safe under mild sedation. | Davide Bona Letizia Laface Luigi Bonavina Emmanuele Abate Moshe Schaffer Ippazio Ugenti Stefano Siboni Rosaria Carrinola | 2010 | World Journal of Gastroenterology2010，16，18： | 2 |
| 15 | Conservative and surgical treatment of esophago-gastric anastomotic leaks显示文摘 | Sarli D Bona D Abraham M | 2006 | Ann Ital Chir2006，77，5： | 1 |
| 16 | Induction of settlement and metamorphosis of the Pacific oyster,(Crassostrea gigas Thurnbery),by L-dopa and catecholamines显示文摘 | Coon S L Bona D B | 1985 | J Exp Mar Biol Ecol1985，94，： | 1 |
| 17 | Optimal matching of three-dimensional features under geometrical constraints显示文摘 | Calafiore G Bona B | 1997 | Proceedings of the IEEE Conference on Decision and Control (S0191-2216)1997，2，7： | 1 |
| 18 | Exlx sion and redifferentiation of chondrocytes from osteoarthritic cartilage: cells for human cartilage tissue engineering显示文摘 | Hsiel Bona ra ND Wu I Lin JK | 2009 | Tissue FaN Part A2009，15，11： | 1 |
| 19 | Effect of agaricus blaze imurill on the pulmonary tissue of animals with streptozoto cin-induced di- abetes 显示文摘 | Naso FC Mello RN Bona S | 2010 | Exp Diabetes Res2010，，2010： | 1 |
| 20 | The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severely truncated derivatives of AvrBs4 and overexpressed AvrBs3显示文摘 | Schornack S Ballvora A Gürlebeck D Peart J Ganal M Baker B Bonas U Lahaye T | 2004 | The Plant Journal2004，37，1： | 1 |
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