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| 1 | Therapeutic upper gastrointestinal tract endoscopy in Paediatric Gastroenterology显示文摘Since the first report of use of endoscopy in children in the 1970 s, there has seen an exponential growthin published experience and innovation in the field. In this review article we focus on modern age therapeutic endoscopy practice, explaining use of traditional as well as new and innovative techniques, for diagnosis and treatment of diseases in the paediatric upper gastrointestinal tract. | Imdadur Rahman Praful Patel Philip Boger Shahnawaz Rasheed Mike Thomson Nadeem Ahmad Afzal | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 14 |
| 2 | TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies显示文摘AIM:To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors,in combination with the death receptor ligand tumor necrosis factor-related apoptosis inducing ligand(TRAIL),on overcoming TRAIL resistance in hepatocellular carcinoma(HCC)and to study the efficacy of agonistic TRAIL antibodies,as well as the commitment of antiapoptotic BCL-2 proteins, in TRAIL-induced apoptosis. METHODS:Surface expression of TRAIL receptors (TRAIL-R1-4)and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analyzed by flow cytometry and Western blotting,respectively. Knock-down of MCL-1 and BCL-xL was performed by transfecting specific small interfering RNAs.HCC cellswere treated with kinase inhibitors and chemotherapeutic drugs.Apoptosis induction and cell viability were analyzed via flow cytometry and 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. RESULTS:TRAIL-R1 and-R2 were profoundly expressed on the HCC cell lines Huh7 and Hep-G2. However,treatment of Huh7 and Hep-G2 with TRAIL and agonistic antibodies only induced minor apoptosis rates.Apoptosis resistance towards TRAIL could be considerably reduced by adding the chemotherapeutic drugs 5-fluorouracil and doxorubicin as well as the kinase inhibitors LY294002[inhibition of phosphoinositol- 3-kinase(PI3K)],AG1478(epidermal growth factor receptor kinase),PD98059(MEK1),rapamycin(mam- malian target of rapamycin)and the multi-kinase inhibitor Sorafenib.Furthermore,the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL play a major role in TRAIL resistance:knock-down by RNA interference increased TRAIL-induced apoptosis of HCC cells.Additionally, knock-down of MCL-1 and BCL-xL led to a significant sensitization of HCC cells towards inhibition of both c-Jun N-terminal kinase and PI3K.CONCLUSION:Our data identify the blockage of survival kinases,combination with chemotherapeutic drugs and targeting of antiapoptotic BCL-2 proteins as promising ways to overcome TRAIL resistance in HCC. | Bruno Christian Koehler Toni Urbanik Binje Vick Regina Johanna Boger Steffen Heeger Peter R Galle Marcus Schuchmann Henning Schulze-Bergkamen | 2009 | World Journal of Gastroenterology2009，15，47： | 9 |
| 3 | Urine versus brushed samples in human papillomavirus screening: study in both genders显示文摘瞄准:调查尿是否是屏蔽的好媒介并且是否在提取 DNA 和人的乳头状瘤病毒(HPV ) 的数量之间有关联确实。方法:从 HPV 积极的病人,和 31 个 FVU 标本和从 HPV 积极的女人与宫颈刷子取样的 100 基于液体的宫颈细胞学剩余物的男搭挡在现在的学习, 30 个第一虚空的尿(FVU ) 标本和 20 个 urethroglandular 拖把使用 cervex 刷为β - 滴的存在被检验在里面。Oncogenic HPV 用类型特定的 PCR 被检测。结果:β - 滴在在所有刷的样品被发现,而它被发现在仅仅 68.9% FVU 标本。HPV-PCR 在 60.0% 男刷子是积极的,在 29% 女刷子。分别地, DNA 集中是 0.9998 ng/μ L, 37.0598 ng/μ L 和 0.0207 ng/μ L。结论:尿不是为 HPV 察觉的一个好工具,可能因为低 DNA 集中反映低数量收集了房间。β - 滴在在由实时量的 PCR 的 FVU 是可测量的,但是 DNA 集中与为两性的刷子采样相比是更低的。尿道、颈的拖把的β -globin 确实是 100% ,显示出 DNA 的更高吝啬的集中,导致 HPV 的更高的察觉率。这是连接 DNA 集中到 HPV 的存在的第一篇文章。 | Kathleen D'Hauwers Christophe Depuydt John-Paul Bogers Michel Stalpaert Annie Vereecken Jean-Jacques Wyndaele Wiebren Tjalma | 2007 | Asian Journal of Andrology2007，9，5： | 3 |
| 4 | A general approach to implementation of the 4π participation of 1 - zza - 1,3 - butadienes in diels-alder reactions显示文摘 | BOGER D L CORBETT W L CURRANT T | 1991 | J Am Chem Soc1991，113，： | 2 |
| 5 | Room temperature, endo-selective lumodiene-controlled cycloaddition reactions of Nsulfonyl - 4 - (ethoxycarbonyl) - 1 - aza - 1,3 - butadienes显示文摘 | BOGER D L CURRANT T | 1990 | J Org Chem1990，55，： | 2 |
| 6 | Utilisation of magnets to enhance gastrointestinal endoscopy显示文摘Methods to assess, access and treat pathology within the gastrointestinal tract continue to evolve with video endoscopy replacing radiology as the gold standard. Whilst endoscope technology develops further with the advent of newer higher resolution chips, an array of adjuncts has been developed to enhance endoscopy in other ways; most notable is the use of magnets. Magnets are utilised in many areas, ranging from endoscopic training, lesion resection, aiding manoeuvrability of capsule endoscopes, to assisting in easy placement of tubes for nutritional feeding. Some of these are still at an experimental stage, whilst others are being increasingly incorporated in our everyday practice. | Imdadur Rahman Praful Patel Philip Boger Mike Thomson Nadeem Ahmad AfzalImdadur | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 2 |
| 7 | The importance of biological factors (bcl-2,bax,p53,PCNA,MI HPV and angiogenesis) in invasive cervical cancer显示文摘 | Tjalma WA Weyler JJ Bogers JJ | 2001 | Eur J Obstet Gynecol Reprod Biol2001，97，2： | 1 |
| 8 | Low dialysance of asymmetric dimethylarginine (ADMA) - in vivo and in vitro evidence of significant protein binding 显示文摘 | Kielstein JT Boger RH Bode- Boger SM | 2004 | Clinical Nephrology2004，62，4： | 1 |
| 9 | Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease显示文摘 | Boger RH Bode-Boger SM Thiele W | 1998 | J Am Coll Cardiol1998，32，5： | 1 |
| 10 | Rheology of low viscosity, high concentration brown coal suspensions显示文摘 | Y. K. Leong Prof. David V. Boger G. B. Christie D. E. Mainwaring | 1993 | Rheologica Acta1993，，3： | 1 |
| 11 | Courts and contract enforcement in transition agricultural theory and evidence from Poland显示文摘 | Beckmann V Boger S | 2002 | Annual Conference Paper of International Society for the New Institutional Economics2002，，9： | 1 |
| 12 | Computational fluid dynamics design and analysis of a passively suspended Tesla pump left ventricular assist device显示文摘 | Medvitz RB Boger DA Izraelev V | | 0，，05： | 1 |
| 13 | Alterations in the antioxidative system of suspension-cultured soybean cells(Glycine max) induced by oxidative stress显示文摘 | KNORZER O C BURNER J BOGER P | 1996 | Physiologia Plantarum1996，97，2： | 1 |
| 14 | The yielding of waxy crude oils显示文摘 | CHENG C BOGER D V | 1998 | Ind Eng Chem Res1998，37，4： | 1 |
| 15 | Users as innovators: A review, critique, and future research directions 显示文摘 | Bogers M Afuah A Bastian B | 2010 | Journal of Management2010，36，4： | 1 |
| 16 | Letter to the editor re: JAMA article on L - arginine therapy in acute myocardial infarction 显示文摘 | Boger RH | 2006 | Ahem Med Rev2006，11，2： | 1 |
| 17 | Leveraging external sources of innovation:A review of research on open innovation 显示文摘 | West J Bogers M | 2014 | Journal of Product Innovation Management2014，31，4： | 1 |
| 18 | Association planners' satisfaction: An application of importance-performance analysis 显示文摘 | Choi J J Boger C A | 2000 | Journal of Convention & Exhibition Management2000，2，23： | 1 |
| 19 | A pre-conditioned Navier-Stokes method for two-phase flows with application to cavitation prediction显示文摘 | KUNZ R F BOGER D A STINEBR/NG D R | 2000 | Com- puters and Fluids2000，29，31： | 1 |
| 20 | Preconditioned Navier-Stokes method for two-phase flows with application to cavitation prediction显示文摘 | Kunz R F Boger D A Stinebring D R | 2000 | Computers & Fluids2000，29，8： | 1 |
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