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| 1 | 哮喘患者全血在尘螨主要过敏原刺激下辅助性T淋巴细胞1/辅助性T淋巴细胞2细胞内细胞因子的表达与偏移显示文摘目的对尘螨过敏的哮喘儿童外周全血体外持续给予尘螨主要过敏原Der p和Der f刺激,观察辅助性T淋巴细胞(Th)内细胞因子的表达,探讨过敏原暴露对Th1/Th2偏移的影响。方法选择尘螨皮试阳性的哮喘患者23例,采集全血,体外与尘螨主要过敏原Der p、Der f共同孵育培养8h,以单克隆抗体对T淋巴细胞表面抗原、细胞内白介素(IL)-4,干扰素(IFN)-γ进行标记,应用流式细胞技术检测Th细胞内细胞因子的表达。结果哮喘患者全血体外Der p、Der f持续暴露后(过敏原暴露组),Th0、Th1、Th2表达率分别为(0.83±0.45)%、(10.70±4.42)%、(2.16±1.17)%,非过敏原暴露组Th0、Th1、Th2表达率分别为(0.93±0.52)%、(9.19±3.75)%、(1.67±0.82)%。过敏原暴露组Th2表达率显著高于非过敏原暴露组(P<0.05),而两组Th0、Th1表达率的差异无显著性(P>0.05)。过敏原暴露组因Th2增高,Th1/Th2比例降低,Th1/Th2平衡向Th2偏移,与非过敏原暴露组的差异有显著性(P<0.01)。结论Der p、Der f对Th细胞有明显的选择性,过敏原的持续暴露促进Th2优势表达,Th1/Th2平衡向Th2转化,可能是引起哮喘症状反复和加重的机制之一。因此,过敏原的回避和特异性的脱敏治疗也是哮喘治疗的措施之一,应予以必要的重视。 | 邵洁 A.Purohit 石学耕 俞善昌 邓伟吾 F.de Blay | 2005 | 上海医学2005，28，8： | 12 |
| 2 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 3 | 消融的冰川:加拿大班夫国家公园亚高山带鲍湖中持久性有机氯的主要来源显示文摘有机氯杀虫剂和多氯联苯(PCB)是环境中普遍而稳固的化合物。现已查明,由于它们从温暖的地区逐渐蒸发出来,并在较冷的地区凝聚下来,因而它们富集在寒冷的环境中。在本研究中,我们的结果是,消融的冰川供给阿尔伯达亚高山带湖泊中的有机氯输入量为50%~97%,而提供的水量为73%。对氚的分析结果表明,在夏季的中、晚期,至少10%的冰川消融物是在1950~1970年期间沉积下来的,这期间它受到有机氯更多的污染。这一发现表明,气候变暖可能会使消融的冰川成为日益增多的淡水污染物来源。由于有机物贫乏的冰川粘土对多氯联苯这样的疏水化合物的吸附能力有限,因此冰川水流带来的有机氯大多呈溶解状态。 | Jules M. Blais David W. Schindler Derek C. G. Muir Martin Sharp David Donald MelissaLafrenière Eric Braekevelt William M. J. Strachan 周立志 | 2001 | AMBIO-人类环境杂志2001，30，7： | 4 |
| 4 | 正确识别并治疗急性心肌梗死患者所发生的抑郁与焦虑显示文摘The objective of this study was to determine the ability of providers(medical residents and nurse practitioners) on inpatient cardiac units to recognize and appropriately treat patients with clinically significant depression and anxiety among a cohort admitted with acute myocardial infarction. Patients within 72 hours of acute myocardial infarction underwent screening with the Standardized Clinical Instrument for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition module for major depressive disorder(MDD), the Beck Depression Inventory(BDI-Ⅱ), and the Beck Anxiety Inventory(BAI). In addition, the study psychiatrist and a treatment team clinician independently assessed whether they believed that patients had clinically significant depression or anxiety. Prescription of antidepressants and benzodiazepines during hospitalization was recorded by chart review. Assessments were completed for 74 patients. Providers identified< 15%of patients with current MDD or with a BDI score ≥10; 11%of patients with current MDD had appropriate treatment with antidepressants. There was no significant correlation of providers’assessment of depression with current MDD, BDI scores, or psychiatrists’clinical assessment of depression. In contrast, providers identified 31%of patients with a BAI score ≥10 and 50%of patients who were assessed by psychiatrists as anxious; >80%of patients with high anxiety received benzodiazepines. Providers’assessments of anxiety were significantly correlated with BAI scores and with psychiatrists’clinical assessments. In conclusion, medical residents and nurse practitioners routinely under-recognize and undertreat depression among patients with acute myocardial infarction on inpatient cardiac units. Recognition and treatment of anxiety is substantially better, up to 50%of patients who are found to be anxious by psychiatrists after acute myocardial infarction remain unrecognized. | Huffman J.C. Smith F.A. Blais M.A. 杜媛 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 5 | 纵向通风隧道内火灾烟气流动的控制(英文)显示文摘讨论了纵向通风隧道火灾和相关烟气形成现象。利用计算机流体动力模型模拟烟气流动,获得可以与试验数据进行比较的预测结果。在Richardson数字基础上,采用了不同参考稳定值,结果发现,直接利用火灾热释放速率所获得的温度值会产生最有用的结果。试验结果与数值预测结果的比较发现,两者吻合较好。笔者验证了利用容积测定火源模拟火灾的情况。结果的准确性很大程度上取决于对墙和屋顶的热传递。 | STEPHANE GAILLOT ALISTAIR REVELL DOMINIQUE BLAY JEAN-PIERRE VANTELON PASCAL DEBERTEIX | 2006 | 消防科学与技术2006，25，3： | 2 |
| 6 | Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial显示文摘 | Jaap Verweij Paolo G Casali John Zalcberg Axel LeCesne Peter Reichardt Jean-Yves Blay Rolf Issels Allan van Oosterom Pancras CW Hogendoorn Martine Van Glabbeke Rossella Bertulli Ian Judson | 2004 | 2004 (9440)2004，，9440： | 2 |
| 7 | Simultaneous sewage sludge digestion and metal leaching—Effect of sludge solids concentration显示文摘 | R.D. Tyagi J.F. Blais N. Meunier H. Benmoussa | 1996 | Water Research1996，，1： | 2 |
| 8 | Comparison of the effects of an angiotensin-converting enzyme inhibitor and a vasopeptidase inhibitor after myocardial infarction in the rat显示文摘 | Lapointe N Blais C Jr Adam A | 2002 | J Am Coll Cardiol2002，39，10： | 2 |
| 9 | New three-stage in vitro model for infant colonic fermentation with immobilized fecal microbiota 显示文摘 | CECILE CINQUIN GWENAELLE Le BLAY | 2006 | FEMS Microbiol Ecol2006，，57： | 1 |
| 10 | Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxieity in the mouse brain显示文摘 | Blais V Rivest S | 2004 | J Immunol2004，172，11： | 1 |
| 11 | Gefitinib in second line treatment of metastatic or locally advanced synovial sarcoma expressing HERI:A phase Ⅱ trial of EORTC Soft Tissue and Bone Sarcoma Group显示文摘 | Blay J Le Cesne A Whelan J | 2006 | J Clin Oncol2006，24，： | 1 |
| 12 | Chiral bis(amino alcohol)oxalamides as ligands for asymmetric catalysis,Ti(Ⅳ)catalyzed enantioselective addition of diethylzinc to aldehydes显示文摘 | BLAY G FERNANDEZ I MARCO-ALEIXANDRE A | 2005 | Tetrahedron:Asymmetry2005，16，6： | 1 |
| 13 | A systematic review and canadian consensus recommendations on the use of biomarkers in the treatment of non-small cell lung cancer 显示文摘 | Ellis P M Blais N Soulieres D | 2011 | J Thorac Oncol2011，6，8： | 1 |
| 14 | Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction 显示文摘 | Huffman JC Smith FA Blais MA | 2008 | Psyehosomaties2008，49，4： | 1 |
| 15 | Primary CNS lymphoma ofT-cell origin: a descriptive analysis from the international primaryCNS lymphoma collaborative group 显示文摘 | Shenkier TN Blay JY O’neill BP | 2005 | J Clin Oncol2005，23，10： | 1 |
| 16 | Evaluation of insomnia: validity of 3 questionnaires显示文摘 | Blais FC Gendron L Mimeault V | 1997 | Encephale1997，23，6： | 1 |
| 17 | Reduced myocardial ischemia reperfusion injury in toll - like receptor 4 - deficient mice显示文摘 | Oyama J Blais C Liu X | 2004 | Circulation2004，109，： | 1 |
| 18 | Diagnosing,treating,and preventing venous thromboembolism in patients with cancer显示文摘 | Blais N | 2008 | Clin J Oncol Nurs2008，12，6： | 1 |
| 19 | Trabectedin (Tr) in the treatment of advanced uterine leiomyosarcomas (U- LMS) :Results of a pooled analysis of five single - agent phase Ⅱ studies using the recommended dose显示文摘 | Judson IR Blay J Chawla SP | 2010 | J Clin Oncol2010，28，10： | 1 |
| 20 | Dendritic cell infiltration and prognosis of early stage breast cancer 显示文摘 | Treilleux I Blay JY Bendriss-Vermare N | 2004 | Clin Cancer Res2004，10，22： | 1 |
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