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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Re-bleeding events in patients with obscure gastrointestinal bleeding after negative capsule endoscopy显示文摘AIM: To investigate long-term re-bleeding events after a negative capsule endoscopy in patients with obscure gastrointestinal bleeding(OGIB) and the risk factors associated with the procedure.METHODS: Patients referred to Hospital Egas Moniz(Lisboa, Portugal) between January 2006 and October 2012 with OGIB and a negative capsule endoscopy were retrospectively analyzed. The following study variables were included: demographic data, comorbidities, bleeding-related drug use, hemoglobin level, indication for capsule endoscopy, post procedure details, work-up and follow-up. Re-bleeding rates and associated factors were assessed using a Cox proportional hazard analysis. The Kaplan-Meier method was used to estimate the cumulative incidence of re-bleeding at 1, 3 and 5 years, and the differences between factors were evaluated.RESULTS: The study population consisted of 640 patients referred for OGIB investigation. Wireless capsule endoscopy was deemed negative in 113 patients(17.7%). A total of 64.6% of the population was female, and the median age was 69 years. The median follow-up was forty-eight months(interquartile range 24-60). Re-bleeding occurred in 27.4% of the cases. The median time to re-bleeding was fifteen months(interquartile range 2-33). In 22.6%(n = 7) of the population, small-bowel angiodysplasia was identified as the culprit lesion. A univariate analysis showed that age > 65 years old, chronic kidney disease, aortic stenosis, anticoagulant use and overt OGIB were risk factors for re-bleeding; however, on a multivariate analysis, there were no risk factors for re-bleeding. The cumulative risk of re-bleeding at 1, 3 and 5 years of follow-up was 12.9%, 25.6% and 31.5%, respectively.Patients who presented with overt OGIB tended to rebleed sooner(median time for re-bleeding: 8.5 mo vs 22 mo).CONCLUSION: Patients with OGIB despite a negative capsule endoscopy have a significant re-bleeding risk; therefore, these patients require an extended follow-up strategy. | Pedro Magalhes-Costa Miguel Bispo Sofia Santos Gilberto Couto Leopoldo Matos Cristina Chagas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 3 |
| 3 | Correlating the amount of urea, creatinine, and glucose in urine from patients with diabetes mellitus and hypertension with the risk of developing renal lesions by means of Raman spectroscopy and principal com- ponent analysis显示文摘 | Jeyse Aliana Martins Bispo Elzo Everton de Sousa Vieira Landulfo Silveira Jr | 2013 | Journal of biomedical optics2013，18，8： | 1 |
| 4 | Chronic multiple knee ligament injuries : epidemiological analyss of more than one hundred cases 显示文摘 | Bispo Jr RZ Kawano CT Guedes AV | 2008 | Clinics ( Sao Pau!o)2008，63，1： | 1 |
| 5 | Correlating the amount of urea,creatinine,and glucose in urine from patients with diabetes mellitus and hypertension with the risk of developing renal lesions by means of Raman spectroscopy and principal com- ponent analysis显示文摘 | Jeyse Aliana Martins Bispo Elzo Everton de Sousa Vieira Landulfo Silveira Jr | 2013 | Journal of biomedical optics2013，18，8： | 1 |
| 6 | Periodontal thera- py and biomarkers related to cardiovascular risk 显示文摘 | Moura Foz A Alexandre Romito G Manoel Bispo C | 2010 | Minerva Stomatol2010，59，5： | 1 |
| 7 | Parosteal lipoma of the femur with hyperostosis: case report and literature, review 显示文摘 | Bispo Junior R Z Guedes A V | 2007 | Clinics (Sao Paulo)2007，62，5： | 1 |
| 8 | Bandageto fix a peripheral intravenous- catheter: anintegrative literature review 显示文摘 | Bispo Silva A Zanetti M | 2004 | Revista Brasileira de Enfermagem2004，57，2： | 1 |
| 9 | EW-PESQ: A Quality Assessment Method for Speech Signals Sampled at 48 kHz显示文摘 | Bispo B C Esquef P A A Biscainho L W P | 2010 | Journal of Acoustic Engineering Society2010，58，4： | 1 |
| 10 | Catalytic dehydration of fructose to HMF over sulfonic acid functionalized periodic mesoporous organosilicas:Role of the acid density显示文摘 | BISPO C VIGIER K D O | 2014 | Catalysis Science & Technology2014，4，8： | 1 |
| 11 | Chronic multiple knee ligament injuries;epidemiological analysis of more than one hundred cases显示文摘 | Bispo RZ Jr Kawano CT Guedes AV | 2008 | Clinits2008，63，： | 1 |
| 12 | Chronic multiple knee ligament injuries: epidemiological analysis of more than one hundred cases 显示文摘 | Bispo Jr RZ Kawano CT Guedes AV | 2008 | Clinics (Sao Paulo)2008，63，1： | 1 |
| 13 | Emerging 8-Methoxy-flu- oroquinolone resistance among methicillin-susceptible staphylococ- cus epidermidis isolates recovered from patients with endophthalmi- tis显示文摘 | Bispo PJM Alfonso EC Flynn HW | 2013 | J Clin Microbiol2013，51，9： | 1 |
| 14 | Virulence factors genes of Staphylococcus spp. isolated from caprine subclinical mastitis显示文摘 | Sandra Renata Sampaio Salaberry André Becker Sim?es Saidenberg Eveline Zuniga Priscilla Anne Melville Franklin Ger?nimo Bispo Santos Ednaldo Carvalho Guimar?es Fábio Gregori Nilson Roberti Benites | 2015 | Microbial Pathogenesis2015，，： | 1 |
| 15 | Effects of calf diet, antioxidants,packaging type and storage time on beef steak storage显示文摘 | Franco D Gonzdlez L Bispo E | 2012 | Meat Science2012，90，4： | 1 |
| 16 | Advances in the microbio- logical diagnosis of sepsis显示文摘 | Andrade SS Bispo PJ Gales AC | 2008 | Shock2008，30，： | 1 |
| 17 | Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells显示文摘 | Bispo de JM Zambuzzi WF Ruela de Sousa RR | 2008 | Biochimie2008，90，6： | 1 |
| 18 | Toxicity and genotoxicity of industrial soils polluted by polycyclic aro- matic hydrocarbons ( PAHs ) 显示文摘 | BISPO A JOURDAIN M J JAUZEIN M | 1999 | Organic Geochem- Istry1999，30，： | 1 |
| 19 | Effect of finishing and ageing time on quality attributes of loin from the meat of Holstein- Fresian cull cows显示文摘 | FRANCO D BISPO E GONZ LEZ L | 2009 | Meat Science2009，83，3： | 1 |
| 20 | Effect of finishing and ageing time on quality attributes of loin from the meat of Holstein -Fresian cull cows显示文摘 | Franco D Bispo E Gonzdlez L | 2009 | Meat science2009，83，3： | 1 |
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