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| 1 | Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach显示文摘Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies. | Mariano Bisbal Mónica Sanchez | 2019 | Neural Regeneration Research2019，14，5： | 4 |
| 2 | The 2 '-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 3 | Protein kinase D regulates trafficking of dendritic membrane proteins in developing neurons显示文摘 | Bisbal M Conde C Donso M | 2008 | J Neurosci2008，28，37： | 1 |
| 4 | The 2'-5' oligoadenylate/ RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation 显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 5 | LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cul- tured neurons 显示文摘 | Rosso S Bollati F Bisbal M | 2004 | Mol Biol Ce112004，15，7： | 1 |
| 6 | The 2-5A/RNase L/RNase L in- hibitor (RLI) pathway regulates mitochon- drial mRNAs stability in interferon alpha-treated H9 cells 显示文摘 | Le Roy F Bisbal C Silhol M | 2001 | J Bio Chem2001，276，48： | 1 |
| 7 | Holmium:YAG laser vaporization of recurrent papillary tumours of the bladder under local anaesthesia显示文摘 | Jonler M Lund L Bisballe S | 2004 | BJU Int2004，94，3： | 1 |
| 8 | Mycobiota and mycotoxin producing fungi from cocoa beans显示文摘 | S NCHEZ-HERV S M GIL J V BISBAL F | 2008 | International Journal of Food Microbiology2008，125，3： | 1 |
| 9 | LIMK1 regulates Golgi dynamics,traffic of Golgi-derived vesicles,and process extension in primary cultured neurons显示文摘 | ROSSO S BOLLATI F BISBAL M | 2004 | Mol Biol Cell2004，15，7： | 1 |
| 10 | Holmium: YAG laser vaporization of recurrent papillary tumours of the bladder under local anaesthesia显示文摘 | JONLER M LUND L BISBALLE S | 2004 | BJU International2004，94，3： | 1 |
| 11 | The 2-SA/RNase L/RNase L inhibitor (RLI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells显示文摘 | Le Roy F Bisbal C Silhol M | 2001 | J Biol Chem2001，276，48： | 1 |
| 12 | The 2' -5' oligoadeny- late/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation 显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 13 | A new component of the in- terferon-regulated 2-5 A pathway显示文摘 | Bisbal C Martinand C Silhol M et aL Cloning and character- ization of a RNase L inhibitor | 1995 | J Biol Chem1995，270，13： | 1 |
| 14 | Holmium: YAG laservaporization of recurrent papillary tumours of the blad-der under local anaesthesia显示文摘 | Jonler M Lund L Bisballe S | 2004 | BJU Int2004，94，3： | 1 |
| 15 | Holmium: YAG laser vaporization of recurrent papillary tumours of the bladder under local anaesthesia显示文摘 | LUND L BISBALLE S | 2004 | BJU Int2004，94，3： | 1 |
| 16 | Hol- mium: YAG laser vaporization of re- current papillary tumours of the blad- der under local anaesthesia 显示文摘 | Jonler M Lund L Bisballe S | 2004 | BJU International2004，94，3： | 1 |
| 17 | Comparison of the TBARS assay and BODIPY CII probes for assessing lipid peroxidation in red deer spermatozoa 显示文摘 | Dominguez-Rebolledo A E Martinez-Pastor F Fernandez-Santos M R dcl Olmo E Bisbal A Ros-Santaella J L Garde J J | 2010 | Reproduction in Domestic Animals-Zuchthygiene2010，45，： | 1 |
| 18 | Mycobiota and mycotoxin producing fungi from cocoa beans显示文摘 | Sánchez-Hervás M Gil J V Bisbal F | | 0，，： | 1 |
| 19 | Holmium: YAG laser vaporization of recurrent papillary tumours of the bladder under local anaesthesia显示文摘 | JONLER M LUND L BISBALLE S | 2004 | BJU Int2004，94，3： | 1 |
| 20 | The 2' - 5' oligoa- denylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation 显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
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