|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach显示文摘Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies. | Mariano Bisbal Mónica Sanchez | 2019 | Neural Regeneration Research2019，14，5： | 4 |
| 2 | Description of starving condition in summer flounder Paralichthys dentatus early history stage 显示文摘 | Bisbal G A Bengtson D A | 1988 | Fish bulletin1988，93，2： | 1 |
| 3 | Development of the digestive tract in larval summer flounder显示文摘 | BISBAL G A BENGTSON D A | 1995 | Journal of Fish Biology1995，47，： | 1 |
| 4 | Legacy Information Systems: Issues and Directions 显示文摘 | Bisbal J | 1999 | IEEE Software1999，10，9： | 1 |
| 5 | The 2 '-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 6 | Fast nosological imaging using canonical correlation analysis of brain data obtained by two‐dimensional turbo spectroscopic imaging显示文摘 | TeresaLaudadio M. CarmenMartínez‐Bisbal BernardoCelda SabineVan Huffel | 2008 | NMR Biomed2008，，4： | 1 |
| 7 | Development of the digestive tract in larval summer flounder显示文摘 | Bisbal G A Bengtson D A | 1995 | Journal of Fish Biolo- gy1995，47，2： | 1 |
| 8 | Protein kinase D regulates trafficking of dendritic membrane proteins in developing neurons显示文摘 | Bisbal M Conde C Donso M | 2008 | J Neurosci2008，28，37： | 1 |
| 9 | The 2'-5' oligoadenylate/ RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation 显示文摘 | Bisbal C Silhol M Laubenthal H | 2000 | Mol Cell Biol2000，20，14： | 1 |
| 10 | Description of the starving condition in summer flounder, Paralichthys dentatus, early life history stages显示文摘 | Bisbal G A Bengtson D A | 1995 | Fish Bull1995，93，： | 1 |
| 11 | Development of the digestive tract in larval summer flounder 显示文摘 | Bisbal G A Bengtson DA | 1995 | J Fish Biol1995，47，： | 1 |
| 12 | Effects of delayed feeding oil survival and growth of summer flounder Paralichthys dentatus larvae 显示文摘 | BISBAL G A BENGTSON D A | 1995 | Marine Ecology Progress Series1995，121，： | 1 |
| 13 | LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cul- tured neurons 显示文摘 | Rosso S Bollati F Bisbal M | 2004 | Mol Biol Ce112004，15，7： | 1 |
| 14 | Development of the digestive tract in larval summer flounder显示文摘 | Bisbal G A Bengtson D A | 1995 | J Fish Biol1995，47，： | 1 |
| 15 | Description of the starving condition in summer flounder, Paralichthys dentatus, early life history stages显示文摘 | BISBAL G A BENGTSON D A | 1995 | Fishery Bulletin1995，93，2： | 1 |
| 16 | Low-Power Pipelined ADC Design for Wireless LANs显示文摘 | Arias J Bisbal D San Pablo J | 2004 | IEEE Journal of Solid- State Circuits2004，39，12： | 1 |
| 17 | Development of the digestivetract in larval summer flounder 显示文摘 | Bisbal G A Bengtson D A | 1995 | Journal of FishBiology1995，47，2： | 1 |
| 18 | Development of the digestive tract in larval summer flounder显示文摘 | Bisbal G A Bengtson D A | 1995 | Journal of Fish Biology1995，47，： | 1 |
| 19 | An Analysis Framework for Electronic Health Record Systems显示文摘 | Bisbal J Berry D | 2011 | Methods Inf Med2011，50，2： | 1 |
| 20 | Development of the digestive tract in larval summer flounder 显示文摘 | Bisbal G A Bengtson D A | 1995 | J Fish Biol1995，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员