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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms显示文摘AIM: To investigate the effect of interleukin-8(IL-8) on neural retinal ganglion cells(RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the cell viability was assessed by Cell Counting Kit 8(CCK-8). Apoptosis was measured by examining nuclear morphology and quantifying with flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction(RT-qP CR) and Western blot were used to investigate the expression of apoptosis-related genes. RESULTS: CCK-8 assay showed that IL-8 significantly inhibits the viability of RGC-5 cells in a dose-dependent manner. Cell apoptosis assays exhibited higher apoptotic rate in IL-8 treatment group compared to control group. We further found that IL-8 could promote Bax and caspase-3 expressions, but decrease the level of Bcl-2 in the aspect of m RNA and protein. However, pre-treatment with G31P partly attenuated these effects in RGC-5 cells(P<0.05).CONCLUSION: These results indicate that anti-proliferation effects of IL-8 through induction of cell apoptosis regulated by Bcl-2, Bax and caspase-3 expressions, can be ameliorated by G31P. | Jing-Jing Wang Walana Williams Bing Wang Jing Wei Xia Lu Jya-Wei Cheng John R Gordon Jing-Min Li Fang Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 3 |
| 3 | New Condition Assessment Procedure for Asphalt Pavement Layers, Using Failing Weight Deflectometer Deflections 显示文摘 | XU Bing RANJITHAN S R KIM R Y | 2002 | Transportation Research Record2002，1806，： | 1 |
| 4 | Online information search: vacation planning process 显示文摘 | Bing P Daniel R | 2006 | Annals of Tourism Research2006，33，3： | 1 |
| 5 | Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice显示文摘 | David R Beers Weihua Zhao Bing Liao | | 0，，05： | 1 |
| 6 | Sensitivity Analysis in Shape Optimization of Continuum Structure 显示文摘 | Wang Shuyu Sun Yan bing Gallagher R H | 1985 | Computer and Structures1985，20，2： | 1 |
| 7 | Percutaneous transcatheter assessment of the left main coronary artery: current status and future directions显示文摘 | Bing R Yong AS Lowe HC | 2015 | JACC Cardiovasc Interv2015，8，12： | 1 |
| 8 | Relative fiber uniformity between parent and F1 and F2 generations in cotton显示文摘 | Dever J K Bing J R Gannawy | 1992 | Crop Sci1992，32，： | 1 |
| 9 | Succinoylation of wheat straw hemicelluloses with a low degree of substitution in aqueous systems显示文摘 | Sun X F Bing X | 2002 | Journal of Applied Polymer Science2002，83，4： | 1 |
| 10 | Microbubble dynamics visualized in the intact capillary circulation 显示文摘 | Feinstein S B Shah P M Bing R J | 1984 | J Am Coil Cardiol1984，4，3： | 1 |
| 11 | Succinoylation of wheat straw hemicelhloses with a low degree of substitution in aque- ous system 显示文摘 | Sun R C Sun X F Bing X | 2002 | Appl Polym Sci2002，83，： | 1 |
| 12 | No reflow in ST elevation myocardial infarction:a new way forward-显示文摘 | Bing R Lowe HC | 2014 | Coron Artery Dis2014，25，8： | 1 |
| 13 | Exogenous surfaetant and partial liquid ventilation显示文摘 | Mrozek J D Smith K M Bing D R | 1997 | Am J Respir Crit Care Med1997，156，41： | 1 |
| 14 | Aconnected countable hausdorff spaces显示文摘 | BING R H | 1953 | Proc Amer Math Soc1953，4，： | 1 |
| 15 | Diurnal changes in hypothalamic neumpeptide and SOCS3 expression:Effects of lactation and relationship with serum leptin and food intake显示文摘 | Denis R G Bing C Brocklehurst S | 2004 | J Endocrinot2004，183，1： | 1 |
| 16 | DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months 显示文摘 | Catherine M R Thomas R A Bing Y Janice D John P C Scott D L | 2008 | Journal of Diabetes Science and Technology2008，2，3： | 1 |
| 17 | Analysis of fiber Fabry-Perot interferometric sensors using low-coherence light sources显示文摘 | YU Bing WANG An-bo PICKRELL G R | 2006 | Journal of Lightwave Technology2006，24，4： | 1 |
| 18 | Y chromosome haplotypes reveal prehistorical migrations to the Himalayas显示文摘 | Su Bing Xiao ChunJie Deka R | 2000 | Hum Genet2000，107，： | 1 |
| 19 | Diumal changes in hypothalamic neuropeptide and SOCS-3 expression: effects of lactatian and relatianship with serum leptin and food intake 显示文摘 | Denis R G Bing C Brocklehurst S | 2004 | J Endoerinol2004，183，1： | 1 |
| 20 | A New Three-step Search Algorithm for Block Motion Estimation显示文摘 | Li R X Zeng Bing Liou M L | 1994 | IEEE Transactions on Circuits and System for Video Technology1994，4，4： | 1 |
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