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| 1 | MicroRNA-21 in the pathogenesis of acute kidney injury显示文摘Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or death.Therefore,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat AKI.However,the mech-anisms modulating the pathogenesis of AKI still remain largely undetermined.MicroRNAs(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expres-sion.MicroRNA-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in AKI.As a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing AKI.This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI. | Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li | 2013 | Protein & Cell2013，4，11： | 18 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay显示文摘Plasma quinolone concentrations are not routinely measured in clinical practice.However,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients.In this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate method.After the assay procedure was optimized,the standard curve of sparfloxacin was established.The practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/mL.The recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,respectively.To demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin. | Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 4 | Chirality communications between inorganic and organic compounds显示文摘1|INTRODUCTION Chirality spans over almost every size range,from mole-cules to biological systems and even to galaxies.It is one of the fascinating geometrical properties with a lot of amazing manifestations in the material world.As chemi-cal researchers,we are more interested in chirality at the molecular scale and nanoscale.Chiral molecules are found important in life science,agrochemicals,pharma-ceutical industries,biosensing,display materials,and so forth.1–5 Chirality stems from a structure lacking sym-metry elements of inversion symmetry and mirror‐plane,which makes the structure not superimposable with its mirror image.Without these two kinds of symmetries,any structure is chiral,besides conventional chiral organics or spiral inorganic structures.The essence of chirality is the stereochemistry of molecules or nanostructures. | Bing Ni Helmut Cölfen | 2021 | SmartMat2021，2，1： | 2 |
| 5 | Estimating saturated hydraulic conductivity in spatially variable fields using neural network ensembles 显示文摘 | KAMBAN P AMIN E BING C S | 2006 | Soil Science Society of America Journal2006，70，6： | 1 |
| 6 | Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY显示文摘 | Frankish HM Pickavance | 1998 | Am J Physiol1998，274，2： | 1 |
| 7 | Weight loss in tumour-hearing mice is not associated with changes in resistin gene expression in white adipose tissue 显示文摘 | Gomez-Ambrosi J Zabalegui N Bing C | 2002 | Horm Metab Res2002，34，1112： | 1 |
| 8 | High-Quality Video View Interpolation Using a Layered Representation显示文摘 | Sing Bing Kang Matthew Uyttendaele Simon Winder Richard Szeliski | 2004 | ACM Transactions on Graphics (S0730-0301)2004，23，3： | 1 |
| 9 | Impact of sodium sulfate on soil frost heaving in an open system显示文摘 | Bing H He P Yang C | 2007 | Applied Clay Science2007，35，34： | 1 |
| 10 | TLR3 and TLR4 ex- pression in healthy and diseased human endometrium 显示文摘 | Allhorn S Bing C Koch AA | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
| 11 | An Intelligent Admission Control Scheme for Next Generation Wireless Systems using Distributed Genetic Algorithms显示文摘 | D Karabudak C C Huang B Bing | 2004 | IEEE communications society2004，3，： | 1 |
| 12 | In-line process condition monitoring expert system for injection molding显示文摘 | Felix T s Chan Henry C W Lau Bing Jiang | 2000 | Journal of Materials Processing Technology2000，101，： | 1 |
| 13 | 显示文摘 | Zhu L P Liao G H Bing N C | 2011 | Journal of Solid State Chemistry2011，184，： | 1 |
| 14 | Succinoylation of wheat straw hemicelluloses with a low degree of substitution in aqueous systems显示文摘 | Sun X F Bing X | 2002 | Journal of Applied Polymer Science2002，83，4： | 1 |
| 15 | Succinoylation of wheat straw hemicelhloses with a low degree of substitution in aque- ous system 显示文摘 | Sun R C Sun X F Bing X | 2002 | Appl Polym Sci2002，83，： | 1 |
| 16 | Laparoscope - assisted diagnosis and treatment of prepyloric web in children report of three cases 显示文摘 | Bing L Wei - Bing C Shou - Qing W Ye - Bo W | 2013 | J Pediatr Surg2013，48，16： | 1 |
| 17 | Automic faoce microscope 显示文摘 | Bing G Quate C F Gerber C | 1986 | Physic Review Letter1986，56，： | 1 |
| 18 | Positive correlation between in vivo oxidized LDL and LDL immune complexes显示文摘 | Bing H Wang J Zhang C | 2004 | Clin Bio Chem2004，37，1： | 1 |
| 19 | Zine-alpha2-glyeoprotein, a lipid mobilizing factor,is expressed in adipocytes and is up-regulated in mice with cancer cachexia显示文摘 | Bing C Bao Y Jenkins J | 2004 | Proc Natl Acad Sci USA2004，101，8： | 1 |
| 20 | PAR-4:a possible new target for age-re- lated disease显示文摘 | Qinan W Ling Z Bing C | 2014 | Expert Opin Ther Targets2014，18，8： | 1 |
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