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| 1 | Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing显示文摘We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer.As opposed to conventional microneedle fabrication methods,this technique neither requires complex and expensive manufacturing facilities nor expertise in microfabrication.While most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness,we show that by introducing a two-step“Print&Fill”mold fabrication method,it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating tissue.Studying first the effect of varying design input parameters and print settings,it is shown that printed needles are always shorter than specified.With decreasing input height,needles also begin displaying an increasingly greater than specified needle base diameter.Both factors contribute to low aspect ratio needles when attempting to print submillimeter height needles.By setting input height tall enough,it is possible to print needles with high-aspect ratios and tip radii of 20–40μm.This tip sharpness is smaller than the specified printer resolution.Consequently,high-aspect ratio sharp needle arrays are printed in basins which are backfilled and cured in a second step,leaving sub-millimeter microneedles exposed resulting microneedle arrays which can be used as male masters.Silicone female master molds are then formed from the fabricated microneedle arrays.Using the molds,both carboxymethyl cellulose loaded with rhodamine B as well as polylactic acid microneedle arrays are produced and their quality examined.A skin insertion study is performed to demonstrate the functional capabilities of arrays made from the fabricated molds.This method can be easily adopted by the microneedle research community for in-house master mold fabrication and parametric optimization of microneedle arrays. | Kevin J.Krieger Nicky Bertollo Manita Dangol John T.Sheridan Madeleine M.Lowery Eoin D.O’Cearbhaill | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 2 | Assessing Landscape Health: A Case Study from Northeastern Italy显示文摘 | PIETRO BERTOLLO | 2001 | Environmental Management2001，，3： | 3 |
| 3 | Evidences for a multiple sex chromosome system with female heterogamety in Apareiodon affinis (Pisces:Parodontidae)显示文摘 | Filho O M Bertollo L A C Junior P M G | 1980 | Caryologia1980，，33： | 1 |
| 4 | Antinociceptive and antiedematogenic activities of fenofibrate,an agonist of PPAR alpha,and pioglitazone,an agonist of PPAR gamma显示文摘 | Oliveira AC Bertollo CM Rocha LT | | 0，，1： | 1 |
| 5 | Multiple sex chromosomes in the genus Hoplias(Pisces:Erythrinidae)显示文摘 | Bertollo L A C Takahashi C S Filho O M | 1983 | Cytologia1983，，48： | 1 |
| 6 | Mental preparation strategies of elite modern pentathletes显示文摘 | MAURIZIO BERTOLLO BEATRICE SALTARELLI CLAU- DIO ROBAZZA | 2009 | Psychol Sport Exe2009，10，： | 1 |
| 7 | The Intracavitary ECG Method for Positioning the Tip of Centralvenous Catheters: Results of an Ltalian Multicenter Study显示文摘 | Pittiruti M Bertollo D Briglia E | 2012 | J Vasc Access2012，13，3： | 1 |
| 8 | The intracavitary ECG method for positioning the tip of central venous catheters: re- sults of an Italian multicenter study显示文摘 | Pittiruti M Bertollo D Briglia E | 2012 | J Vasc Access2012，13，3： | 1 |
| 9 | Competence, achievement goals, motivational climate, and pleasant psychobioso- cial states in youth sport显示文摘 | BORTOLI L BERTOLLO M COMANI S | 2011 | Journal of Sports Sciences2011，29，2： | 1 |
| 10 | Assessing ecosystem health in governed landscapers:A framework for developing core indicators显示文摘 | BERTOLLO P | 1998 | Ecosystem Health1998，，4： | 1 |
| 11 | Assessing ecosystem health in governed landscapers: A framework for developing core indicators显示文摘 | BERTOLLO P | 1998 | Ecosystem Health1998，，4： | 1 |
| 12 | Influence of Electron Beam Melting Manufactured Implants on Ingrowth and Shear Strength in an Ovine Model显示文摘 | Nicky Bertollo Ruy Da Assuncao Nicholas J | 2012 | The Journal of Arthroplasty2012，27，8： | 1 |
| 13 | Correlation of the RTS ( Revised Trauina Score) and RAPS (Rapid Acute Physiology Score) in rotor- wing pre- hospital care 显示文摘 | Bertollo S Rodenberg H | 1994 | Air Med J1994，13，3： | 1 |
| 14 | Assessingecosystemhealthingovernedlandscapes:Aframeworkfordevelopingcoreindicators显示文摘 | Bertollo P | 1998 | EcosystemHealth1998，4，1： | 1 |
| 15 | MTHFR genetic variability on coronary artery disease development 显示文摘 | Biselli PM Guerzoni AR Goloni Bertollo EM et aL | 2009 | Rev Assoe Med ras2009，55，3： | 1 |
| 16 | Heretical thoughts about food hypersensitivity:small bowel manometry as an objective way to document gut reactions 显示文摘 | Bassotti G Bertollo A Spinozzi F | 1997 | Eur J Clin Nutr1997，51，9： | 1 |
| 17 | Antinociceptive and antiedematogenic avtivities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma 显示文摘 | OLIVEIRA AC BERTOLLO CM ROCHA LT | 2007 | Eur Pharmacol2007，561，13： | 1 |
| 18 | Effects of mercury on the isolated heart muscle are prevented by DTT and cysteine 显示文摘 | Vassallo D V Moreira C M Oliveira E M Bertollo D M Veloso T C | 1999 | Toxicol Appl Pharmacol1999，156，： | 1 |
| 19 | The intracavitary ECG method for positioning the tip of central venous catheters:results of an Italian multicenter study显示文摘 | Pittiruti M Bertollo D Briglia E | 2012 | J Vasc Access2012，13，3： | 1 |
| 20 | Assessing ecosystem health in governed landscapers:A fi:amework for developing core indicators显示文摘 | BERTOLLO P | 1998 | Ecosystem Health1998，，4： | 1 |
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