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| 1 | 小肠肿瘤:前瞻性评价MR小肠灌肠检查显示文摘目的前瞻性评价有症状的病人MR小肠灌肠检出小肠肿瘤的准确性。以传统的内镜、组织标本、胶囊内镜、常规小肠灌肠和随访结果作为参考标准。方法人类研究委员会批准了本项研究计划,病人签署知情同意书。150例(男性83例.女性67例;平均年龄42.6岁,年龄范围17~84岁)临床怀疑小肠肿瘤,且既往上、下胃肠道内镜检查结果正常的病人进行了MR小肠灌肠检查。MR小肠灌肠表现依下述内容进行前瞻性评价:局限性肠壁增厚、小肠肿块和小肠狭窄。 | G. Masselli E. Polettini E. Casciani L Bertini A. Vecchioli G. Gualdi 孙东辉(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 11 |
| 2 | Experimental Investigation of Separation and Transition Processes on a High-Lift Low-Pressure Turbine Profile Under Steady and Unsteady Inflow at Low Reynolds Number显示文摘The effects induced by the presence of incoming wakes on the boundary layer developing over a high-lift low-pressure turbine profile have been investigated in a linear cascade at mid-span.The tested Reynolds number is 70000,typical of the cruise operating condition.The results of the investigations performed under steady and unsteady inflow conditions are analyzed.The unsteady investigations have been performed at the reduced frequency of f+=0.62,representative of the real engine operating condition.Profile aerodynamic loadings as well as boundary layer velocity profiles have been measured to survey the separation and transition processes.Spectral analysis has been also performed to better understand the phenomena associated with the transition process under steady inflow.For the unsteady case,a phase-locked ensemble averaging technique has been employed to reconstruct the time-resolved boundary layer velocity distributions from the hot-wire instantaneous signal output.The ensemble-averaging technique allowed a detailed analysis of the effects induced by incoming wakes-boundary layer interaction in separation suppression.Time-resolved results are presented in terms of mean velocity and unresolved unsteadiness time-space plots. | Satta F Simoni D Ubaldi M Zunino P Bertini F | 2010 | Journal of Thermal Science2010，19，1： | 9 |
| 3 | Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study显示文摘AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed'on demand'.Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score.Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles.Liver function can remain stable in the long-term, with optimal medium term survival.This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. | Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 4 | Profile and Secondary Flow Losses in a High-Lift LPT Blade Cascade at Different Reynolds Numbers under Steady and Unsteady Inflow Conditions显示文摘The aerodynamic flow field downstream of a Low-Pressure High-Lift(HL)turbine cascade has been experimentally investigated for different Reynolds numbers under both steady and unsteady inflows,in order to analyse the cascade performance under real engine operating conditions.The Reynolds number has been varied in the range 100000 | Satta F. Simoni D. Ubaldi M. Zunino P. Bertini F. | 2012 | Journal of Thermal Science2012，21，6： | 5 |
| 5 | Endotics system vs colonoscopy for the detection of polyps显示文摘AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation. | Emanuele Tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria | 2010 | World Journal of Gastroenterology2010，16，43： | 5 |
| 6 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
| 7 | Combined Experimental and Numerical Investigations on the Roughness Effects on the Aerodynamic Performances of LPT Blades显示文摘The aerodynamic performance of a high-load low-pressure turbine blade cascade has been analyzed for three different distributed surface roughness levels(Ra) for steady and unsteady inflows. Results from CFD simulations and experiments are presented for two different Reynolds numbers(300000 and 70000 representative of take-off and cruise conditions, respectively) in order to evaluate the roughness effects for two typical operating conditions. Computational fluid dynamics has been used to support and interpret experimental results, analyzing in detail the flow field on the blade surface and evaluating the non-dimensional local roughness parameters, further contributing to understand how and where roughness have some influence on the aerodynamic performance of the blade. The total pressure distributions in the wake region have been measured by means of a five-hole miniaturized pressure probe for the different flow conditions, allowing the evaluation of profile losses and of their dependence on the surface finish, as well as a direct comparison with the simulations. Results reported in the paper clearly highlight that only at the highest Reynolds number tested(Re=300000) surface roughness have some influence on the blade performance, both for steady and unsteady incoming flows. In this flow condition profile losses grow as the surface roughness increases, while no appreciable variations have been found at the lowest Reynolds number. The boundary layer evolution and the wake structure have shown that this trend is due to a thickening of the suction side boundary layer associated to an anticipation of transition process. On the other side, no effects have been observed on the pressure side boundary layer. | Marco Berrino Fabio Bigoni Daniele Simoni Matteo Giovannini Michele Marconcini Roberto Pacciani Francesco Bertini | 2016 | Journal of Thermal Science2016，25，1： | 3 |
| 8 | Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: A prospective cohort study显示文摘 | Irene Bargellini Rodolfo Sacco Elena Bozzi Marco Bertini Barbara Ginanni Antonio Romano Antonio Cicorelli Emanuele Tumino Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | European Journal of Radiology2011，，6： | 2 |
| 9 | Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients显示文摘Sorafenib is an effective anti-angiogenic treatment forhepatocellular carcinoma(HCC). The assessment of tumor progression in patients treated with sorafenib is crucial to help identify potentially-resistant patients,avoiding unnecessary toxicities. Traditional methods to assess tumor progression are based on variations in tumor size and provide unreliable results in patients treated with sorafenib. New methods to assess tumor progression such as the modified Response Evaluation Criteria in Solid Tumors or European Association for the Study of Liver criteria are based on imaging to measure the vascularization and tumor volume(viable or necrotic). These however fail especially when the tumor response results in irregular development of necrotic tissue. Newer assessment techniques focus on the evaluation of tumor volume,density or perfusion. Perfusion computed tomography and Dynamic ContrastEnhanced-UltraS ound can measure the vascularization of HCC lesions and help predict tumor response to antiangiogenic therapies. Mean Transit Time is a possible predictive biomarker to measure tumor response. Volumetric techniques are reliable,reproducible and time-efficient and can help measure minimal changes in viable tumor or necrotic tissue,allowing the prompt identification of non-responders. Volume ratio may be a reproducible biomarker for tumor response. Larger trials are needed to confirm the use of these techniques in the prediction of response to sorafenib. | Rodolfo Sacco Valeria Mismas Antonio Romano Marco Bertini Michele Bertoni Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Luca Giacomelli Sara Marceglia Irene Bargellini | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 10 | Changes in foliar carbon isotope composition and seasonal stomatal conductance reveal adaptive traits in Mediterranean coppices affected by drought显示文摘We estimated water-use efficiency and potential photosynthetic assimilation of Holm oak(Quercus ilex L.) on slopes of NW and SW aspects in a replicated field test examining the effects of intensifying drought in two Mediterranean coppice forests. We used standard techniques for quantifying gas exchange and carbon isotopes in leaves and analyzed total chlorophyll, carotenoids and nitrogen in leaves collected from Mediterranean forests managed under the coppice system. We postulated that responses to drought of coppiced trees would lead to differential responses in physiological traits and that these traits could be used by foresters to adapt to predicted warming and drying in the Mediterranean area. We observed physiological responses of the coppiced trees that suggested acclimation in photosynthetic potential and water-use efficiency:(1) a significant reduction in stomatal conductance(p<0.01) wasrecorded as the drought increased at the SW site;(2) foliar δ13C increased as drought increased at the SW site(p<0.01);(3) variations in levels of carotenoids and foliar nitrogen, and differences in foliar morphology were recorded, and were tentatively attributed to variation in photosynthetic assimilation between sites. These findings increase knowledge of the capacity for acclimation of managed forests in the Mediterranean region of Europe. | Giovanni Di Matteo Luigi Perini Paolo Atzori Paolo De Angelis Tiziano Mei Giada Bertini Gianfranco Fabbio Giuseppe Scarascia Mugnozza | 2014 | Journal of Forestry Research2014，25，4： | 2 |
| 11 | ELR + CXC chemokines and their receptors (CXC chemokine receptor 1 and CXC chemokine receptor 2) as new therapeutic targets显示文摘 | Cinzia Bizzarri Andrea Rosario Beccari Riccardo Bertini Michela Rita Cavicchia Simona Giorgini Marcello Allegretti | 2006 | Pharmacology and Therapeutics2006，，1： | 2 |
| 12 | Prediction of response to cardiac resynchronization therapy combining two different threedimensional analyses of left ventricular dyssynchrony显示文摘 | Auger D Bertini M Marsan NA | 2011 | Am J Cardiol2011，108，5： | 1 |
| 13 | Paramagnetic constraints: an aid for quick solution structure determination of paramagnetic metalloproteins显示文摘 | Bertini I Luchinat C Parigi G | 2002 | Concepts Magn Reson2002，14，4： | 1 |
| 14 | Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials显示文摘 | Granchi C Bertini S Macchia M | 2010 | Curr Med Chem2010，17，7： | 1 |
| 15 | Characterization of the binding interface between the copper ehaperone Atxl and the first eytosolie domain of Cee2 ATPase显示文摘 | ARNESANO F BANCI L BERTINI I | 2001 | J Biol Chem2001，276，41： | 1 |
| 16 | The INSURE method in preterm infants of less than 30 weeks'gestation 显示文摘 | DANI C CORSINI I BERTINI G | 2010 | Matem Fetal Neonatal Med2010，23，9： | 1 |
| 17 | Cytopathology of nipple discharge due to Pityrosporum orbiculare and cocci in an elderly women显示文摘 | Bertini B Kuttin ES Beemer AM | 1975 | Acta Cytol1975，19，1： | 1 |
| 18 | Pharmaeokineties of enrofloxacin in the sea bass (Dieentrarehus labrax)显示文摘 | Intorre L Ceechini S Bertini S | 2000 | Aquaculture2000，182，： | 1 |
| 19 | Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants a prospective double-blind study显示文摘 | Dani C Biadaili R Bertini G | 2002 | Biol Neonate2002，82，2： | 1 |
| 20 | Magnetic susceptibility in paramagnetic NMR显示文摘 | Bertini I Luchinat C Parigi G | 2002 | Prog NMR Spectr2002，40，： | 1 |
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