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| 1 | Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy) aniline显示文摘A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents. | Thierry Youmbi Fonkui Monisola Itohan Ikhile Freddy Munyololo Muganza Marthe Carine Djuidje Fotsing Charmaine Arderne Xavier Siwe-Noundou Rui Werner Macedo Krause Derek Tantoh Ndinteh Patrick Berka Njobeh | 2018 | Journal of Chinese Pharmaceutical Sciences2018，27，5： | 2 |
| 2 | Vascular endothelial growth factor and its receptors in control and diabetic rat eyes显示文摘 | Gilbert RE Vranes D Berka JL Kelly DJ Cox A Wu LL | 1998 | Lab Invest1998，78，8： | 1 |
| 3 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 4 | Risk of cesarean delivery with elective induction of labor at term in nulliparous women 显示文摘 | Seyb ST Berka RJ Socol ML | 1999 | Obstet Gynrcol1999，94，4： | 1 |
| 5 | Human rhinovirus type 2 uncoating at the plasma membrane is not affected by a PH gradient but is affected by the membrane potential显示文摘 | Berka U Khan A Blaas D | 2009 | J Virol2009，83，8： | 1 |
| 6 | Molecular characterization and expression of a phytase gene from thermophilic fungus Therrnomyces lanuginosus显示文摘 | BERKA R M REY M W BROWN K M | 1998 | Applied and Environment Microbiology1998，64，11： | 1 |
| 7 | Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire 显示文摘 | Glanville J Zhai W Berka J | 2009 | Proceedings of the National Academy of Sciences of the United States of America2009，106，20： | 1 |
| 8 | Discretization and Grouping: Preprocessing Steps for Data Mining显示文摘 | Berka P Braba I | 1998 | Principles of Data Mining and Knowledge Discovery1998，，： | 1 |
| 9 | Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenases -2 and nitric oxide 显示文摘 | Wilkson - Berka JL | 2004 | Curr Phurm Des2004，10，： | 1 |
| 10 | Renoprotective and antihypertensive effects of combined valsartan and perindopril in progressive diabetic nephropathy in the transgenic (mRen-2) 27rat显示文摘 | Wilkinson Berka JL Gibbs NJ Cooper ME | 2001 | Nephrol Dial Transplat2001，16，7： | 1 |
| 11 | Hydrazine and its salts and derivatives as reductimetric reagents显示文摘 | Berka A Vulterin J Zyka J | 1963 | Chemi Analyst1963，52，： | 1 |
| 12 | High Efficiency Transgene Segregation in Co-Transformed Maize Plants using an Agrobacterium Tumefaciens 2 T-DNA Binary System显示文摘 | Michael Miller Laura Tagliani Ning Wang Benjamin Berka Dennis Bidney Zuo-Yu Zhao | | 0，2002，： | 1 |
| 13 | A polymerase chainreaction (PCR) method for sex and species determination withnovel controls for deoxyribonucleic acid (DNA) template length显示文摘 | Gaensslen RE Berka KM Grosso DA | 1992 | J Forensic Sci1992，37，1： | 1 |
| 14 | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression显示文摘 | Zhang Y Berka V Song A | 2014 | J Clin Invest2014，124，6： | 1 |
| 15 | Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris显示文摘 | Berka R M Grigoriev I V Otillar R | 2011 | Nature Biotechnology2011，29，10： | 1 |
| 16 | Surface Complexation Modeling of K^+,NO3^-,SO4^2-,Ca^2+,F^-,Co^2+,and Cr^3+ Ion Adsorption on Silica Gel显示文摘 | Berka M Bányai I | 2001 | J Colloid Interface Sci2001，233，： | 1 |
| 17 | Regulation of the glaA gene of Aspergillus niger显示文摘 | Fowler T Berka RM Ward M | 1990 | Curr Genet1990，18，： | 1 |
| 18 | Comparative ge- nomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris 显示文摘 | Berka RM Grigoriev IV Otillar R | 2011 | Nat Biotechnol2011，29，10： | 1 |
| 19 | Superoxide generation from endothelial nitric-oxide synthase:a Ca2+/ calmodulin-dependent and tetrahydrobiopterin regulatory process显示文摘 | Xiao Y Tsai AL Berka V | 1998 | J Biol Chem1998，273，25： | 1 |
| 20 | Renoprotective and antihypertensive effects of combined valsartan and perindopril in progressive diabetic nephropathy in the transgenic (mRen-2)27rat显示文摘 | Wilkinson Berka JL Gibbs NJ Cooper ME | 2001 | Nephrol Dial Transplat2001，16，7： | 1 |
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