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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Effects of scheduling and ascites-associated macrophages on combined antiproliferative activity of alpha-2b interferon and gamma-interferon in a clonogenic assay显示文摘 | Junichiro Higashihara Toshiaki Saito Michael E. Berens Charles E. Welander | 1988 | Cancer Chemotherapy and Pharmacology1988，，3： | 2 |
| 3 | A computer method for the calculation of equilibrium constants for the formation of physical clusters of molecules: application to small water clusters显示文摘 | Swope W C Anderson H C Berens P H | 1982 | Journal of Chemical Physics1982，76，： | 1 |
| 4 | Image Indexing Using Compressed Color Histogram显示文摘 | BERENS J FINLAYSON G D | 2000 | IEEE Trans on Vision Image and Signal Processing2000，147，4： | 1 |
| 5 | The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis ofreovirus encephalitis显示文摘 | Berens HM Tyler KL | 2011 | J Virol2011，85，8： | 1 |
| 6 | Limitierungsverfahren yon Reihen mehrdimensionaler Kugelfunktionen und deren Saturationsverhalten 显示文摘 | Berens H Butzer P L Pawelke S | 1968 | Publ Res Inst Math Sci Ser A1968，4，： | 1 |
| 7 | Linear Drives in the Focal Point显示文摘 | BERENS P | 2001 | Manufacturing Technology & Machine Tool2001，4，： | 1 |
| 8 | Amplification of the inosinate dehydrogenase fene in Trypanosoma brucei gambiense due to an increase in chromosome copy number 显示文摘 | Wilson K Berens R Sifri C D | 1994 | J Biol Chem1994，269，28： | 1 |
| 9 | Sympathetic responses to induction of anaesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，： | 1 |
| 10 | A computer simulation method for the calculation of equilibrium constants for the formation of physical clusters of molecules:Application to small water clusters显示文摘 | Swope W C Andersen H C Berens P H | 1982 | Journal of Chemical Physics1982，76，1： | 1 |
| 11 | Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethysulphate and drug-directed Fe2, cleavage of 16S rRNA显示文摘 | Bauer G Berens C Projan S J | 2004 | JAntimicrob Chemother2004，53，4： | 1 |
| 12 | Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration显示文摘 | Wu Y Siadaty M S Berens M E | 2008 | Oncogene2008，27，52： | 1 |
| 13 | Identification of Fnl4/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma显示文摘 | Watts OS Tran NL Berens ME | 2007 | Int J Cancer2007，121，10： | 1 |
| 14 | Molecular Mechanisms of Glioma Cell Migration and Invasion显示文摘 | Demuth T Berens M E | 2004 | Journal of Neurooncology2004，70，2： | 1 |
| 15 | Regulation of Glioma Cell Migration by Serine-Phosphorylated P311 显示文摘 | McDonough WS Tran NL Berens ME | 2005 | Neoplasia2005，7，9： | 1 |
| 16 | Inverse theorems for polynomials显示文摘 | BERENS H LORENTZ G | 1975 | Indiana Univ Math Journal1975，21，8： | 1 |
| 17 | Corporate associations in th?; academicliterature : Three main streams of thought in the reputation measure-ment literature 显示文摘 | BERENS G van KIEL C B M | 2004 | Corporate Reputation Review2004，7，2： | 1 |
| 18 | Gene regulation by tetracyclines:Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes显示文摘 | Hillen W | 2003 | Eur J Biochem2003，270，15： | 1 |
| 19 | Inverse theorems for Bernstein Polynomials显示文摘 | Berens H Lorentz G G | 1972 | Indiana Univ Math J1972，21，： | 1 |
| 20 | Sympathetic responses to induction of anesthesia in humans with propofol or etomidate显示文摘 | Ebert TJ Muzi M Berens R | 1992 | Anesthesiology1992，76，5： | 1 |
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