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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Optical properties of the metals Al, Co, Cu, Au, Fe, Pb, Ni, Pd, Pt, Ag, Ti, and W in the infrared and far infrared 显示文摘 | Ordal M A Long L L Bell R J | 1983 | Applied Optics1983，22，7： | 2 |
| 3 | Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants :pleiotropic phenotypes include drought tolerance 显示文摘 | CARLOS ROMERO JOSE M BELLES JOSE L | 1997 | Planta1997，201，： | 1 |
| 4 | SIRT3 suppresses hypoxia inducible factor la and tumor growth by inhibiting mitochondrial ROS production 显示文摘 | Bell E L Emerling B M Rieoult S J | 2011 | Oncogene2011，30，26： | 1 |
| 5 | Genome-wide functional analysis of human cell-cycle regulators显示文摘 | MUKHERJI M BELL R SUPEKOVA L | 2006 | Proc Natl Acad Sci USA2006，103，14： | 1 |
| 6 | Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins 显示文摘 | Bell L R Maine E M Schedl P | 1988 | Cell1988，55，6： | 1 |
| 7 | 显示文摘 | Ordal M A Long L L Bell R J | 1983 | Appl Opt1983，22，7： | 1 |
| 8 | CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status显示文摘 | Kinter A L Hennessey M Bell A | 2004 | Journal of Experimental Medicine2004，200，3： | 1 |
| 9 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 10 | Optical properties of the metals Al,Co,Cu,Au,Fe,Pb,Ni,Pd,Pt,Ag,Ti and W in the infrared and far infrared显示文摘 | M A Ordal L L Long R J Bell | | 0，，： | 1 |
| 11 | Use of molecular markers in a breeding program for Corus florida显示文摘 | Trigiano R N Schlarbaum S E Bell L M | 1996 | Proc Southern Nurseryman’s Res Conf1996，41，： | 1 |
| 12 | The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study显示文摘 | Sasahra A A Bell W R Simon T L Stengle J M Sherry S | 1975 | Thromb Diath Haemorrh1975，33，： | 1 |
| 13 | Air temperature and winter mortality: implications for the persistence of the invasive mussel, Perna viridis in the intertidal zone of the south- eastern United States显示文摘 | Firth L B Knights A M Bell S S | 2011 | J Experim Mar Biol Ecol2011，400，25： | 1 |
| 14 | Electronic health record based decision support to improve asthma care: a cluster randomized trial 显示文摘 | BELL L M GRUNDMEIER R LOCALIO R | 2010 | Pediatrics2010，125，4： | 1 |
| 15 | Optical properties of the metals AI,Co,Cu,Au,Fe,Pb,Ni,Pd,Pt,Ag,Ti,and W in the infrared and far infrared显示文摘 | ORDAL M A LONG L L BELL R J | 1983 | App Opt1983，22，2： | 1 |
| 16 | CD25(+)CD4(+) regulatory T cells from the perip-heral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and associated with favorable clinical markers of disease status显示文摘 | Kinter A L Hennessey M Bell A | 2004 | J Exp Med2004，200，： | 1 |
| 17 | Fast electron transport in laser-produced plasmas and the KALOS code for solution of the Vlasov Fokker Planck equation显示文摘 | Bell A R Robinson A P L Sherlock M | 2006 | Plasma Phys Control Fusion2006，48，： | 1 |
| 18 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 19 | Vitellogenic blood protein synthesis by insect fat body 显示文摘 | Pan M L Bell W J Teller W H | 1969 | Science N Y1969，165，： | 1 |
| 20 | Physical symptoms,coping styles and quality of life in recurrent ovarian cancer:A prospective population-based study over the last year of life显示文摘 | Price M A Bell M L Sommeijer D W | 2013 | Gynecologic Oncology2013，130，1： | 1 |
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