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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | Renal dopaminergic system:Pathophysiological implications and clinical perspectives显示文摘Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent. | Marcelo Roberto Choi Nicolás Martín Kouyoumdzian Natalia Lucía Rukavina Mikusic María Cecilia Kravetz María Inés Rosón Martín Rodríguez Fermepin Belisario Enrique Fernández | 2015 | World Journal of Nephrology2015，4，2： | 2 |
| 3 | HIF-1 activation induces doxorubicin resistance in MCF-7 3-D spheroids via P-glycoprotein ex- pression:a potential model of the chemo-resistance of invasive micro- papillary carcinoma of the breast 显示文摘 | Doublier S Belisario DC Polimeni M | 2012 | BMC Cancer2012，12，： | 1 |
| 4 | Factory trials to optimize the application of dextranase in raw sugar manufacture: Part II显示文摘 | GILLIAN E ADRIAN M BELISARIO M | 2007 | International sugar journal2007，109，： | 1 |
| 5 | Factory trials to optimize the application of dextranase in raw sugar manufacture: Part Ⅱ显示文摘 | GILLIAN E ADRIAN M BELISARIO M | 2007 | International sugar journal2007，，109： | 1 |
| 6 | Seasonal variations in optimized applications of intermediate temperature stable ot-amylase in raw sugar manufacture显示文摘 | GILLIAN E ADRIAN M BELISARIO M | 2010 | International sugar journal2010，，112： | 1 |
| 7 | First report of Alternaria alternata causing leaf spot on English walnut显示文摘 | BELISARIO A FORTI E CORAZZA L | 1999 | Plant disease1999，83，7： | 1 |
| 8 | First report of Alternaria species groups involved in disease complexes of ha-zelnut and walnut fruit显示文摘 | I Belisario A Maccaroni M Coramusi A | | 0，，04： | 1 |
| 9 | The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index显示文摘 | Vassallo J Andrade LA | 2006 | Maturitas2006，53，1： | 1 |
| 10 | Immobilised echistatin promotes platelet adhesion and protein tyrosine phosphorylation显示文摘 | Belisario MA Tafuri S Di Domenico C | 2000 | Biochim Biophys Acta2000，1497，2： | 1 |
| 11 | The expression of the hormone receptors in the endometrium and endometfial polyps in post- menpauosal women and its relationship to body mass index 显示文摘 | Belisario MS Vassallo J Andrade LA | 2006 | Matu- ritas2006，53，1： | 1 |
| 12 | Against fusarium wilt of melon there is only breeding显示文摘 | Belisario A Corazza L | 2003 | Cohure Protette2003，32，2： | 1 |
| 13 | Seasonal variations in optimized applications ofintmnediate lmtx,aure stable a-mnylase in raw sugar mml显示文摘 | GILLIAN E ADR/AN M BELISARIO M | 2010 | Irdemational Sugar Jotmml2010，112，： | 1 |
| 14 | Application of dextranases in sugarcane factory:Overcoming practical problems显示文摘 | GILLIAN E ADRIAN M BELISARIO M | | 0，，02： | 1 |
| 15 | Time - Frequency Analysis Techniques Applied to Automotive Noise and Vibration Signals显示文摘 | Belisario Nina Huallpa Jorge Marano | 2008 | SAE2008，，： | 1 |
| 16 | HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycopmtein ex- pression : a potential model of the chemo-resistance of invasive micro- papillary carcinoma of the breast 显示文摘 | Doublier S Belisario DC Polimeni M | 2012 | BMC Cancer2012，12，： | 1 |
| 17 | Prehepatic portal hypertension in rats modifies norepinephrine metabolism in hypothalamus medulla oblongata and portal vein显示文摘 | Prof.Dr. Abraham Lemberg MD Francisco X. Eizayaga MD Marcelo Vatta Biochem Antonio Dominguez PhD Salvador Romay MD Liliana G. Bianciotti Biochem Gabriela Sanso Biochem Belisario Fernández MD | 1993 | Digestive Diseases and Sciences1993，，7： | 1 |
| 18 | Application of dextranases in sugarcane factory:Overcoming practical Problems显示文摘 | GILLIAN E ADRIAN M BELISARIO M | | 0，，12： | 1 |
| 19 | First Report of Alternaria Species Groups Involved in Disease Complexes of Hazelnut and Walnut Fruit显示文摘 | BELISARIO A MACCARONI M CORAMUSI A | 2004 | Plant Disease2004，88，4： | 1 |
| 20 | Brief review of keratoacanthomas and demription of kemto- acanthoma eentfifugum marginatum, another variety of keratoacanthoma 显示文摘 | Belisario JC | 1965 | Aust J Dermat1965，8，2： | 1 |
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