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| 1 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 2 | Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats显示文摘Gonadotropin-releasing hormone(Gn RH) and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury. | Carmen Díaz Galindo Beatriz Gómez-González Eva Salinas Denisse Calderón-Vallejo Irma Hernández-Jasso Eduardo Bautista J Luis Quintanar | 2015 | Neural Regeneration Research2015，10，11： | 2 |
| 3 | On Higher Order Statistics of the Nakagami-m Distribution显示文摘 | VARGAS BAUTISTA J E | 1999 | IEEE Transaction on Vehicular Technology1999，48，3： | 1 |
| 4 | Study of the interfaces between austenite and ferrite grains in P/M duplex stainless steels 显示文摘 | Campos M Bautista A Caceres D | 2003 | Journal of the European Ceramic Society2003，23，15： | 1 |
| 5 | Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasmamembrane calcium-ATPase in human T cells 显示文摘 | BAUTISTA D M HOTH M LEWIS R S | 2002 | J Physiol2002，541，3： | 1 |
| 6 | In vitro antibradykinin activity of Aloe barbadensis gel 显示文摘 | Bautista - Perez R Segura - Cobos D Vazquez - Cruz B | 2004 | Journal of Ethnophar- macology2004，93，1： | 1 |
| 7 | Effect of grafting and cytolinin-induced fruit setting on colour and sugar-content traits in glasshouse-grow triploid watermelon显示文摘 | Lopez-Galarza S Bautista A S Perez D M Miguel A Baixauh C Pascual B Maroto J V Guardiola J L | 2004 | Journal of Horticultural Science&Biotechnology2004，79，6： | 1 |
| 8 | Constitu- tive expression of alpha interferon by skin dendritic ceils confers resistance to infection by foot-and-mouth disease virus 显示文摘 | Bautista EM Ferman GS Gregg D | 2005 | J Virol2005，，79： | 1 |
| 9 | Factor affecting fetal bradycardia following combined spinal epidural for labor analgesia: a matched case-control study显示文摘 | Cheng SL Bautista D Leo S | 2013 | J Anesth2013，27，2： | 1 |
| 10 | Liver expression of proteins controlling interferon-mediated signalling as predictive factors in the response to therapy in patients with hepatitis C virus infection 显示文摘 | Bautista D Bermudez-Silva FJ Lasarte J J | 2007 | J Patho12007，213，3： | 1 |
| 11 | The mentholreceptor TRPM8 is the principal detector ofenvironmental cold 显示文摘 | Bautista D M Siemens J Glazer J M | 2007 | Nature2007，448，7150： | 1 |
| 12 | Isolation of bacterial artificial chromosome DNA by means of improved alkaline lysis and double potassium acetate precipitation 显示文摘 | Villalobos D P Bautista R Canovas F M | 2004 | Plant Mol Biol Rep2004，22，4： | 1 |
| 13 | Cellular and molecular mechanisms of pain显示文摘 | Basbaum AI DM Bautista D Julius | 2009 | Cell2009，139，： | 1 |
| 14 | TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents显示文摘 | Bautista D Jordt S Nikai T | 2006 | Cell2006，124，6： | 1 |
| 15 | Prognostic value of motor evoke potential obtained by transcranial magnetic brain stimulation in motor function recover in patients with acute ischemic stroke显示文摘 | Escudero JV Sancho J Bautista D | 1998 | Stroke1998，29，： | 1 |
| 16 | Acidity and catalytic activity of AlPO4-B2O3 and Al2O3-B2O3 (5-30% B2O3) systems prepared by impregnation显示文摘 | BAUTISTA F M CAMPELO J M GARCIA A LUNA D MARINAS J M MORENO M C ROMERO A A | 1998 | Appl Catal A: Gen1998，170，1： | 1 |
| 17 | Progno stic value of motor evoked potential obtaned by transcranial magnetic brain stimulation in motor function recovery in patients with acute is chemic stroke显示文摘 | Sancho J Bautista D | 1998 | Stroke1998，29，： | 1 |
| 18 | Vanadium oxides supported on TiO2 - Sepiolite and sepiolite : Preparation, structural and acid characterization and catalytic behaviour in selective oxidation of toluene 显示文摘 | BAUTISTA F M CAMPELO J M LUNA D | 2007 | Appl Catal A Gen2007，325，2： | 1 |
| 19 | Pungent products from garlic activate the sensory ion channel TRPA1显示文摘 | Bautista D M Movahed P Hinman A | | 0，，： | 1 |
| 20 | New tools for studying seafloor geotechnical and geoacoustic properties显示文摘 | Stoll R D Bautista E Flood R | | 0，，05： | 1 |
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