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| 1 | Type 2 diabetes mellitus:From a metabolic disorder to an inflammatory condition显示文摘Diabetes mellitus is increasing at an alarming rate and has become a global challenge.Insulin resistance intarget tissues and a relative deficiency of insulin secretion from pancreatic β-cells are the major features of type 2 diabetes(T2D).Chronic low-grade inflammation in T2 D has given an impetus to the field of immuno-metabolism linking inflammation to insulin resistance and β-cell dysfunction.Many factors advocate a causal link between metabolic stress and inflammation.Numerous cellular factors trigger inflammatory signalling cascades,and as a result T2 D is at the moment considered an inflammatory disorder triggered by disordered metabolism.Cellular mechanisms like activation of Tolllike receptors,Endoplasmic Reticulum stress,and inflammasome activation are related to the nutrient excess linking pathogenesis and progression of T2 D with inflammation.This paper aims to systematically review the metabolic profile and role of various inflammatory pathways in T2 D by capturing relevant evidence from various sources.The perspectives include suggestions for the development of therapies involving the shift from metabolic stress to homeostasis that would favour insulin sensitivity and survival of pancreatic β-cells in T2 D. | Iqra Hameed Shariq R Masoodi Shahnaz A Mir Mudasar Nabi Khalid Ghazanfar Bashir A Ganai | 2015 | World Journal of Diabetes2015，6，4： | 36 |
| 2 | Effect of fluence and ambient environment on the surface and structural modification of femtosecond laser irradiated Ti显示文摘Under certain conditions, ultrafast pulsed laser interaction with matter leads to the formation of self-organized conical as well as periodic surface structures(commonly reffered to as, laser induced periodic surface structures, LIPSS). The purpose of the present investigations is to explore the effect of fsec laser fluence and ambient environments(Vacuum &O_2) on the formation of LIPSS and conical structures on the Ti surface. The surface morphology was investigated by scanning electron microscope(SEM). The ablation threshold with single and multiple(N = 100) shots and the existence of an incubation effect was demonstrated by SEM investigations for both the vacuum and the O_2 environment. The phase analysis and chemical composition of the exposed targets were performed by x-ray diffraction(XRD) and energy dispersive x-ray spectroscopy(EDS), respectively. SEM investigations reveal the formation of LIPSS(nano & micro). FFT d-spacing calculations illustrate the dependence of periodicity on the fluence and ambient environment. The periodicity of nano-scale LIPSS is higher in the case of irradiation under vacuum conditions as compared to O_2. Furthermore, the O2 environment reduces the ablation threshold. XRD data reveal that for the O_2 environment, new phases(oxides of Ti) are formed. EDS analysis exhibits that after irradiation under vacuum conditions, the percentage of impurity element(Al) is reduced. The irradiation in the O_2 environment results in 15% atomic diffusion of oxygen. | Umm-i-Kalsoom Shazia Bashir Nisar Ali M Shahid Rafique Wolfgang Husinsky Chandra S R Nathala Sergey V Makarov Narjis Begum | 2016 | Chinese Physics B2016，25，1： | 2 |
| 3 | A completed screen for mutations of the rhodopsin gene in a panel of patients with autosomal dominant retinitis pigmentosa 显示文摘 | Inglehearn CF Keen TJ Bashir R | 1992 | Hum Mol Genet1992，1，： | 1 |
| 4 | Manual suture less small incision cataract surgery in patients with uveitic cata- ract显示文摘 | Bhargava R Kumar P Bashir H | 2014 | Middle East Aft J Ophthalmol2014，21，1： | 1 |
| 5 | Microfluidic biochip for impedance spectroscopy of biological species 显示文摘 | BASHIR R SARIKAYA A | 2001 | Biomedical Microdevices2001，3，3： | 1 |
| 6 | Advanced Eccentricity Fault Recognition in Permanent Magnet Synchronous Motors Using Stator Current Signature Analysis显示文摘 | Bashir M E Mehrsan J R Jawad F | 2014 | Transaction on Power Electronics2014，61，4： | 1 |
| 7 | Comparison of bactericidal activities of silver nanoparticles with common chemical disinfectants 显示文摘 | CHAMAKURA K PEREZ-BALLESTERO R LUO Zhi-ping BASHIR S LID Jing-bo | 2011 | Colloids and Surfaces B: Biointerfaces2011，84，： | 1 |
| 8 | Accumulation and redistribution of fertilizer nitrogen 15 in soft red winter wheat 显示文摘 | Bashir R Norman R J Bacon R K | 1997 | Soil Sci Soc A m J1997，61，： | 1 |
| 9 | Landfill Leachate Treatment byElectrochemical Oxidation显示文摘 | Bashir M J Esa M H Kutty S R | 2009 | Waste Manage2009，29，9： | 1 |
| 10 | The nurotrophins and their receptors in nerve injury and repair显示文摘 | EBADI M BASHIR R M HEIDRICK M L | 1997 | Neurochem Iht1997，30，45： | 1 |
| 11 | A gene related to Caenorhab- ditis elegans spermatogenesis factor fer- 1 is mutated in limb-girdle muscular dystrophy type 2B显示文摘 | Bashir R Britton S Strachan T | 1998 | Nat Genet1998，20，： | 1 |
| 12 | Presentation and management outcome of eclampsia at Ayub Teaching Hospital, Abbottabad显示文摘 | Sultana R Bashir R Khan B | 2005 | J Ayub Med Coil Abbottabad2005，17，2： | 1 |
| 13 | Impact of meningococcal C conjugate vaccine use in Australia 显示文摘 | Booy R Jelfs J E1 Bashir H | 2007 | Med J Aust2007，186，3： | 1 |
| 14 | A Cellular Trojan Horse for delivery ofther apeutic nanoparticles into tumors显示文摘 | Choi M R Stanton - Maxey K J Stanley J K Levin C S Bardhan R Akin D Badve S Sturgis J Robinson J P Bashir B Halas H J and Clare S E | 2007 | Nano Letters2007，7，12： | 1 |
| 15 | Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage显示文摘 | Day CP Bashir R James OF | 1991 | Hepatology1991，14，5： | 1 |
| 16 | Transient expression of betaCl protein differentially regulates host genes related to stress response,chloroplast and mitochondrial functions显示文摘 | Andleeb S Amin I Bashir A Briddon R W Mansoor S | | 0，，： | 1 |
| 17 | Micromechanical cantilever as an ultrasensitive pH microsensor显示文摘 | Bashir R Hilt J Z Elibol O | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 18 | Landfill leachate treat ment by electrochemical oxidation 显示文摘 | BASHIR M J ISA M H KUTTY S R | 2009 | Waste Management2009，29，9： | 1 |
| 19 | Diagnosis and treatment of bacterial meningitis显示文摘 | EI Bashir H Lanndy M Booy R | 2003 | Arch Dis Child2003，88，7： | 1 |
| 20 | The extraordinary antioxidant activity of Vitamin E phosphate显示文摘 | Bashir M R Guido R M M H Wim J F var der Vijgh | 2004 | Biochimica et Biophysica Acta2004，1683，： | 1 |
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