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| 1 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 3 | M and P components of the VEP and their visual fielddistribution显示文摘 | Baseler H A Sutter E E | 1997 | Vis Res1997，37，6： | 1 |
| 4 | The impact of leachate recirculation municipal solid waste landfill operating characteristics显示文摘 | Debra R Reinhart A Basel Al-Yousfi | 1996 | Waste Management and Research1996，14，： | 1 |
| 5 | Evidence and consensus-based Ger- man guiddines for the management of analgesia, sedatioin and delirium in intensive care-short version显示文摘 | Martin J Heymann A Basell K et ol | 2010 | GMS German Medical Science2010，8，2： | 1 |
| 6 | Split hand foot malformation is associated with a reduced level of Dactylin gene expression显示文摘 | Basel D DePaepe A Kilpatrick MW | 2003 | Clin Genet2003，64，： | 1 |
| 7 | The impact of leachate recirculation on municipal solid waste landfill operating characteristics显示文摘 | Debra R Reinhart A Basel Al-Yousfi | 1996 | Waste Management & Research1996，14，4： | 1 |
| 8 | Evidence and Con-sensus -based German Guidelines for the Management ofAnalgesia, Sedation and Delirium in Intensive Care -shortVersion显示文摘 | Martin J Heymann A Basell K | 2010 | Ger Med Sci2010，，8： | 1 |
| 9 | Evidence and consensus-based German guidelines for the management of analgesia,sedation and delirium in intensive care-short version显示文摘 | Martin J Heymann A Basell K | 2010 | Ger Med Sci2010，8，： | 1 |
| 10 | Effect of exogenous polysaccharide-degrading enzymepreparations on ruminal fermentation and digestibilityof nutrients in dairy cows 显示文摘 | HRISTOV A N BASEL C E MELGAR A | 2008 | Animal Feed Scienceand Technology2008，145，1234： | 1 |
| 11 | Evidence and consensus -based German guidelines for the management of analgesia, sedation and delirium in intensive care-short version显示文摘 | Martin J Heyrnann A Basell K | 2010 | Get Med Sci2010，8，2： | 1 |
| 12 | The impact of leachate recirculation on municipal solid waste landfill operating characteristics 显示文摘 | Debra R R Basel A | 1996 | Waste Management & Research1996，14，4： | 1 |
| 13 | The topography of visual evoked response properties across the visual field 显示文摘 | Baseler H A Sutter E E Klern S A | 1994 | Electroencephalogr Clin Neurophysiol1994，90，： | 1 |
| 14 | Evidence and consensus- based German guidelines for the management of analgesia, se- dation and delirium in intensive care-short version显示文摘 | Martin J Heymann A Basell K | 2010 | Gms German Medical Science2010，8，2： | 1 |
| 15 | The topography of visual evoked response properties across the visual field显示文摘 | Baseler H A Sutter E E Klern S A | | 0，，： | 1 |
| 16 | Omega-3 polyunsaturated fatty acids in large doses attenuate seizures,cognitive impairment,and hippocampal oxidative DNA damage in young kindled rats显示文摘 | BASEL A ABDEL-WAHAB JOBRAN M | 2015 | J Neurosci Lett2015，584，： | 1 |
| 17 | The impact of leachate recirculation on municipal solid waste landfill operation characteristics显示文摘 | Debra R Reinhart A Basel Al-Yousfi | 1996 | Waste Management & Research1996，14，： | 1 |
| 18 | A Nonlinear PID Control Scheme for Hard Disk Drive Servosystems显示文摘 | BASEL M ISAYED MUHAMMAD A HAWWA | 2007 | Control and Automation2007，，07： | 1 |
| 19 | Proteomic alterations of distinct mitochondrial subpopula- tions in the type 1 diabetic heart: contribution of protein import dysfunction 显示文摘 | Baseler W A Dabkowski E R Williamson C L | 2011 | Am J Physiol Regul Integr Comp Physiol2011，300，2： | 1 |
| 20 | M and P Components of the VEP and Their Visual Fielddistribution显示文摘 | Baseler H A Sutter E E | 1997 | Vis Res1997，37，6： | 1 |
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