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| 1 | MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα显示文摘In human adipose tissue and obesity,miR-99a expression is negatively correlated with inflammation.Therefore,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes.Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype.Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity.Likewise,knockdown of miR-99a abolished M2 phenotype activation.By means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of miR-99a.Knockdown of TNFαrecapitulated the effect of miR-99a overexpression in M1 BMDMs.In a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+ATMs.Systemic overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 immunostaining.Flow cytometry analysis also showed an increased M2 and a reduced M1 macrophage population.Mimics of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the liver.Furthermore,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and liver.The present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity. | Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya Manoj Kumar Barthwal | 2019 | Cellular & Molecular Immunology2019，16，5： | 7 |
| 2 | 原子干涉仪多频时分复用激光放大控制系统显示文摘研发了一种多频时分复用锥形激光放大控制系统。通过控制种子激光的输出频率和工作时序,此系统可以实现高隔离度单频、比例可调双频、复合多频调制三种不同模式的激光放大。实验研究了该控制系统的光学特性,结果表明输出线偏振激光束间的消光比达30 dB,不同工作模式的切换时间为100 ns。该系统可提高激光器的利用效率,适用于原子干涉精密测量物理及原子干涉仪应用技术等对激光输出功率、集成度要求较高的领域。 | 张文冬 何川 闫思彤 Barthwal Sachin 龙世同 汤彪 周林 王谨 詹明生 | 2018 | 量子电子学报2018，35，3： | 5 |
| 3 | Heavy Metal Accumulation in Medicinal Plants Collected from Environmentally Different Sites显示文摘Objective To estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. Methods Soil and plant samples of Abutilon indicum, Calotropis procera, Euphorbia hirta, Peristrophe bycaliculata, and Tinospora cordifolia were collected from 3 environmentally different sites of the city: heavy traffic area (HTA), industrial area (IA), and residential area (RA). Pb, Cd, Cr, and Ni were estimated in soil and plant samples by inductively coupled plasma emission spectrometry and compared. Results The level of heavy metal was higher in soil than in plant parts studied. Accumulation of heavy metals varied from plant to plant. Pb was the highest in Calotropis procera root from HTA site and the lowest in Peristrophe bycaliculata whole plant from IA site. It was also lower in residential area than in heavy traffic area. Conclusion The level of heavy metal content differed in the same medicinal plant collected from environmentally different sites of the same city. Thus, it reiterates our belief that every medicinal plant sample should be tested for contaminant load before processing it further for medication. | JYOTI BARTHWAL SMITHA NAIR POONAM KAKKAR | 2008 | Biomedical and Environmental Sciences2008，21，4： | 5 |
| 4 | The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-lp transcription and processing in monocytes显示文摘 | Ankita Singh Vishal Singh Rajiv L. Tiwari Tulika Chandra Ashutosh Kumar Madhu Dikshit Manoj K. Barthwal | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 5 | Reactive Oxygen Species-Induced Activation of ERK and p38 MAPK Medi- ates PMA-induced NETs Release from Human Neutrophils 显示文摘 | Ravi S Keshari AnupamVerma Manoj K Barthwal | 2013 | Jour- nal of Cellular Biochemistry2013，114，： | 1 |
| 6 | Fabrication of amphipho- bic surface by using titanium anodization for large-area three-di- mensional substrates显示文摘 | BARTHWAL S KIM Y S LIM S H | 2013 | Journal of Colloid and Interface Sci- ence2013，400，： | 1 |
| 7 | Remote sensing technique for mapping salt affected soils 显示文摘 | VERMA K S SAXENA R K BARTHWAL | 1994 | International Journal of Remote Sensing1994，15，9： | 1 |
| 8 | Macrophages: an elusive yet emerging therapeutic target of atherosclerosis 显示文摘 | Tiwari RL Singh V Barthwal MK | 2008 | Med Res Rev2008，28，4： | 1 |
| 9 | Superhydrophobic and Superoleophobic Copper Plate Fabrication Using Alkaline Solution Assisted Surface Oxidation Methods 显示文摘 | BARTHWAL S KIM Y S LIM S H | 2012 | Interna- tional Journal of Precision Engineering & Manufacturing2012，13，8： | 1 |
| 10 | Macrophages:an el-usive yet emerging therapeutic target of atherosclerosis显示文摘 | Tiwari RL Singh V Barthwal MK | 2008 | Med Res Rev2008，28，4： | 1 |
| 11 | Macrophages: anelusive yet emerging therapeutic target of atherosclerosis显示文摘 | Tiwari RL Singh V Barthwal MK | 2008 | Med Res Rev2008，28，4： | 1 |
| 12 | Remote sensing technique for mapping salt affected soils显示文摘 | Verma K S Saxena R K Barthwal | 1994 | International Journal of Remote Sensing1994，15，9： | 1 |
| 13 | Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils显示文摘 | Keshari R S Verma A Barthwal M K | 2013 | Journal of Cellular Biochemistry2013，114，： | 1 |
| 14 | Glycogen synthase ki- nase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3 显示文摘 | Mishra R Barthwal MK Sondarva G | 2007 | J Bio Chem2007，282，30： | 1 |
| 15 | Macrophages: an elu- sive yet emerging therapeutic target of atherosclerosis 显示文摘 | Tiwari RL Singh V Barthwal MK | 2008 | Med Res Rev2008，28，4： | 1 |
| 16 | Preparation and characterization of nanosize nickel-substituted cobalt ferrites(Co1-xNixFe2O4)显示文摘 | SINGHAL S SINGH J BARTHWAL S K CHANDRA K | | 0，，10： | 1 |
| 17 | Antioxidant levels in the rat brain after nitric oxide synthase inhibition:a preliminaryreport显示文摘 | Barthwal M K Srivastava | 2000 | Redox Rep2000，5，2： | 1 |
| 18 | Fabrication of Amphiphobic Surface by Using Titanium Anodization for Large-area Three-dimensional Substrates显示文摘 | BARTHWAL S KIM Y S LIM S | 2013 | Journal of Colloid and Inter- face Science2013，400，： | 1 |
| 19 | Repulsive Polarons in One-Dimensional Fermi Gases显示文摘Using the variational method, we study the properties of a spin-down impurity immersed in a onedimensional(1 D) spin-up Fermi sea. With repulsive interactions between them, the impurity is dressed up by surrounding particles in Fermi sea and forms a polaron. We clearly calculate the binding energy, effective mass, momentum distribution, Tan contact, and pair correlation. Even in strong repulsive regimes, the results can agree with the exact Bethe Ansatz results. The repulsive polaron energy E+ is below Fermi energy EF and no negative effective masses are found in whole interaction regimes, unequal masses polarons are also calculated. We show a clear momentum distribution and calculate the Tan contact from three different aspects. Furthermore, we explore the particle-hole excitation and find that the hole terms in Fermi sea have a great influence on the polaron energy and contact in repulsive regime. These results show that the variational method can still be used effectively in 1 D repulsive polaron system. | 宋亚东 Sachin Barthwal | 2019 | Communications in Theoretical Physics2019，71，5： | 1 |
| 20 | Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3显示文摘 | Sathyanarayana P Barthwal MK Kundu CN | 2002 | Mol Cell2002，10，： | 1 |
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