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| 1 | MicroRNAs显示文摘 | David P Bartel | 2004 | Cell2004，，2： | 43 |
| 2 | 冠状动脉血流储备的经胸多普勒超声心动图与冠状动脉内多普勒血流测量的对照研究显示文摘目的 ①探讨经胸声学造影二次谐波多普勒超声心动图 (TTDE)探测冠状动脉左前降支(LAD)远端血流的可行性 ;②与冠状动脉内多普勒 (ICD)相对照 ,分析研究LAD冠状动脉血流储备(CFR)。方法 利用TTDE连续检测 110例患者LAD血流。冠状动脉血流速度储备 (CFVR)为注射腺苷后的最大平均血流速度与静息状态平均血流速度的比值。结果 CFVR探测的成功率为 96%。TTDE所探测的CFVR(2 .83± 0 .68)与ICD所探测的结果 (2 .91± 0 .74)密切相关 (r =0 .83 ,Y =0 .76X + 0 .61,P <0 .0 0 1)。结论 TTDE结合声学造影及二次谐波技术是一项可行、可信的无创性探测CFVR的方法 ,可用于冠状动脉病变的探测及冠脉介入治疗的随访。 | 杨娅 Thomas Bartel 王新房 Raimund Erbel | 2002 | 中华超声影像学杂志2002，11，6： | 23 |
| 3 | Genome Analysis of the Ancient Tracheophyte Selaginella tama#scina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance显示文摘 | Zhichao Xu Tianyi Xin Dorothea Bartels Ying Li Wei Gu Hui Yao Sai Liu Haoying Yu Xiangdong Pu Jianguo Zhou Jiang Xu Caicai xi Hetian Lei Jingyuan song Shilin Chen | 2018 | Molecular Plant2018，11，7： | 20 |
| 4 | MicroRNAs: Target Recognition and Regulatory Functions显示文摘 | David P. Bartel | 2009 | Cell2009，，2： | 19 |
| 5 | 精神分裂症抑郁症状的鉴别诊断显示文摘由于受传统观念的影响,束缚了我们对精神分裂症抑郁症状的诊断和处理。本文试图排除这些干扰,综合当代的研究,以提供一个对精神分裂症抑郁症状的认识和鉴别诊断。 | Bartels SJ 向德昭 | 1989 | 国际精神病学杂志1989，31，2： | 13 |
| 6 | 新型无创性冠状动脉血流储备检测经胸壁声学造影二次谐波多普勒技术显示文摘目的 研究经胸壁声学造影二次谐波多普勒超声心动图探测左前降支 (LAD)冠状动脉血流储备 (CFVR)的可行性、安全性及可靠性。方法 46例患者经静脉注射利声显 ,利用二次谐波观察LAD血流 ,对多普勒血流图像质量进行分级。CFVR为注射腺苷后的最大平均血流速度与静息状态平均血流速度的比值。结果 CFVR探测的成功率为 98%。注射腺苷后 ,心率加快 ,血压减低。60 %患者有轻微副反应。CFVR为 2 84± 0 65 ,与冠状动脉内多普勒探测的结果密切相关 (r=0 87,P <0 0 0 1 )。结论 经胸壁声学造影二次谐波多普勒超声心动图可明显提高冠状动脉血流探测的成功率 ,是安全、可行。 | 杨娅 王新房 Thomas Bartel Holger Eggebrecht Loredana Latina Raimund Erbel | 2003 | 中华心血管病杂志2003，31，2： | 11 |
| 7 | MicroRNAs显示文摘 | David P Bartel | 2004 | Cell2004，，2： | 10 |
| 8 | 冠状动脉造影正常者冠状动脉血流储备的经胸多普勒超声研究显示文摘目的 研究经胸多普勒超声心动图 (TTDE)探测冠状动脉 (冠脉 )造影正常者左前降支(LAD)远端血流的准确性 ;与冠脉内超声 (IVUS)相对照 ,分析影响冠脉造影正常者冠脉血流储备 (CFVR)的病理因素。方法 利用TTDE检测 40例冠脉造影正常者的LAD血流。CFVR为注射腺苷后的最大平均血流速率与静息状态平均血流速率的比值。结果 37例患者成功地进行了CFVR的测量。TTDE所检测的CFVR与冠脉内多普勒 (ICD)所检测的结果密切相关 (Y =0 .65X +0 .92 ,r =0 .88,P <0 .0 0 0 1 )。合并高血压的患者CFVR减低。 34例患者行IVUS检查 ,1 7例LAD内有粥样硬化斑块形成。结论 TTDE是一项可行、可信的无创性检测CFVR的方法。冠脉造影正常者LAD内可有斑块形成 。 | 杨娅 Thomas Bartel 王新房 李治安 Raimund Erbel | 2003 | 中华超声影像学杂志2003，12，8： | 9 |
| 9 | Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets显示文摘 | Benjamin P. Lewis Christopher B. Burge David P. Bartel | 2005 | Cell2005，，1： | 8 |
| 10 | Prediction of Mammalian MicroRNA Targets显示文摘 | Benjamin P. Lewis I-hung Shih Matthew W. Jones-Rhoades David P. Bartel Christopher B. Burge | 2003 | Cell2003，，7： | 7 |
| 11 | Transport and Metabolism of the Endogenous Auxin Precursor Indole-3-Butyric Acid显示文摘植物生长和形态发生取决于植物荷尔蒙植物生长素的层次和分布。植物紧通过合成, inactivation,和运输调整活跃植物生长素 indole-3-acetic 酸(IAA ) 的细胞的层次。尽管行动 IAA 进并且从房间好的 transporters 描绘了并且在开发起重要作用,很少对 IAA 先锋的运输被知道。在这评论,我们讨论建议 IAA 先锋 indole-3-butyric 酸(IBA ) 与建议使 IBA 产生代射变化的特定的 IBA 流出搬运人和酶的最近的鉴定一起独立于描绘的 IAA 运输机械被搬运的积累的证据。这些研究在在植物以内维持 IAA 层次和分布支持正常开发为 IBA 揭示了重要角色。 | Lucia C. Strader Bonnie Bartel | 2011 | Molecular Plant2011，4，3： | 7 |
| 12 | Complicated small-bowel diverticulosis: A case report and review of the literature显示文摘当 jejunoileal 憩室稀罕、经常无征状时,他们可以导致长期的非特定或尖锐的症状。与类似于阑尾炎,胆汁或结肠的憩室炎而是他们的急腹症在场的复杂并发症的大多数可以也与不正常的症状出现。作为结果,复杂 jejunoileal 憩室形成的诊断能是相当困难的,并且可以完全取决于外科的探索的结果。当禁止徵候不在时,诊断腹腔镜检查有腹的内容和帮助的彻底的检查的利益到达绝对诊断。有主要吻合的深奥小肠的片断的外科的切除术是在有征兆的复杂 jejunoileal 的病人的比较喜欢的治疗憩室的疾病。与与腹腔镜检查诊断并且与外科的切除术对待的 S 字形的憩室炎一起的复杂空肠憩室炎的一个不正常的演讲被介绍。 | Woubet T Kassahun Josef Fangmann Jens Harms Michael Bartels Johann Hauss | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 13 | Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells显示文摘Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat heart cells. Cells collected at day 3 and 10 of the culture were preincubated with autoantibodies against α1-adrenoceptor and angiotensin II AT1-receptor, agonist phenylephrine and angiotensin II, and control IgG. The pretreated cultured cells were stained for selected mast cell markers tryptase, chymase and TNF-α. The cultured cells were also processed for observation with electron microscopy. The autoantibodies-treatment of the 3-day cultured cells caused both increased intensity of immunofluorescence (p < 0.05) and their enlarged diameters of the mast cells when compared to age-matched ones. In contrast, the fluorescence of preincubated 10-day-old mast cells was decreased compared with controls (p < 0.01). In control samples, the fluorescence of 10-day-old mast cells was significantly higher than that of 3-day-old ones (p < 0.001). Results of electron microscopy examination demonstrated there was an increased granulation of treated 3-day-old mast cells, while a degranulation of mast cells at day 10 of application. The results suggest the modulation effect of the autoantibodies against G-protein-coupled receptors on mast cells, indicating a potential functional link between the autoantibodies against G-protein-coupled receptors and the mast cells in progression of heart disease. | Ludmila Okruhlicova Rosemarie Morwinski Wolfgang Schulze Sabine Bartel Peter Weismann Narcisa Tribulova Gerd Wallukat | 2007 | Cellular & Molecular Immunology2007，4，2： | 6 |
| 14 | Orthotopic liver transplantation for giant liver haemangioma: A case report显示文摘In liver haemangiomas, the risk of complication rises with increasing size, and treatment can be obligatory. Here we present a case of a 46-year-old female who suffered from a giant haemangioma causing severe portal hypertension and vena cava compression, leading to therapy refractory ascites, hyponatremia and venostasis-associated thrombosis with pulmonary embolism. The patients did not experience tumour rupture or consumptive coagulopathy. Surgical resection was impossible because of steatosis of the non-affected liver. Orthotopic liver transplantation was identified as the only treatment option. The patient's renal function remained stable even though progressive morbidity and organ allocation were improbable according to the patient's lab model for end-stage liver disease(lab MELD) score. Therefore, non-standard exception status was approved by the European organ allocation network 'Eurotransplant'. The patient underwent successful orthotopic liver transplantation 16 mo after admission to our centre. Our case report indicates the underrepresentation of morbidity associated with refractory ascites in the lab MELD-based transplant allocation system, and it indicates the necessity of promptly applying for non-standard exception status to enable transplantation in patients with a severe clinical condition but low lab MELD score. Our case highlights the fact that liver transplantation should be considered early in patients with non-resectable, symptomatic benign liver tumours. | Undine G Lange Julian N Bucher Markus B Schoenberg Christian Benzing Moritz Schmelzle Tanja Gradistanac Steffen Strocka Hans-Michael Hau Michael Bartels | 2015 | World Journal of Transplantation2015，5，4： | 6 |
| 15 | Two strategies for prevention of cytomegalovirus infections after liver transplantation显示文摘AIM: To analyze differences in patients' clinical course, we compared two regimes of either preemptive therapy or prophylaxis after liver transplantation.METHODS: This retrospective study was reviewed and approved by the institutional review board of the University of Leipzig. Cytomegalovirus(CMV) prophylaxis with valganciclovir hydrochloride for liver transplant recipients was replaced by a preemptive strategy in October 2009. We retrospectively compared liver transplant recipients 2 years before and after October 2009. During the first period, all patients received valganciclovir daily. During the second period all patients included in the analysis were treated following a preemptive strategy. Outcomes included one year survival and therapeutic intervention due to CMV viremia or infection.RESULTS: Between 2007 and 2010 n = 226 patients underwent liver transplantation in our center. n = 55 patients were D^+/R^- high risk recipients and were excluded from further analysis. A further 43 patients had to be excluded since CMV prophylaxis/preemptive strategy was not followed although there was no clinical reason for the deviation. Of the remaining 128 patients whose data were analyzed, 60 receivedprophylaxis and 68 were treated following a preemptive strategy. The difference in overall mortality was not significant, nor was it significant for one-year mortality where it was 10%(95%CI: 8%-28%, P = 0.31) higher for the preemptive group. No significant differences in blood count abnormalities or the incidence of sepsis and infections were observed other than CMV. In total, 19 patients(14.7%) received ganciclovir due to CMV viremia and/or infections. Patients who were treated according to the preemptive algorithm had a significantly higher rate risk of therapeutic intervention with ganciclovir [n = 16(23.5%) vs n = 3(4.9%), P = 0.003)].CONCLUSION: These data suggest that CMV prophylaxis is superior to a preemptive strategy in patients undergoing liver transplantation. | Philipp Simon Max Sasse Sven Laudi David Petroff Michael Bartels Udo X Kaisers Sven Bercker | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 16 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 17 | Disruption of Arabidopsis CHY1 Reveals an Important Role of Metabolic Status in Plant Cold Stress Signaling显示文摘到学习寒冷发信号,我们与 CBF3 倡导者(CBF3-LUC ) 驾驶的萤火虫酶记者基因的改变的导致寒冷的抄写为 Arabidopsis 屏蔽了异种。一异种, chy1-10,显示减少 CBF3-LUC 冷正式就职光。RNA 胶化污点分析表明内长的 CBF 的那表情也在 chy1 异种被减少。chy1-10 异种植物对冻结处理比更敏感在冷环境适应以后野类型。两野类型并且 chy1 异种植物对在温暖的温度的导致黑暗的饥饿敏感,尽管 chy1 植物是稍微更敏感的。这黑暗敏感被冷温度压制在野类型然而并非在 chy1。组成的 CBF3 表示部分在寒冷救 chy1-10 植物的敏感到黑暗处理。chy1 异种积累 CBF3-LUC 冷正式就职的氢过氧化物罐头还原剂的反应的氧种类,和申请的高水平在野类型。在异种的基因有缺陷者的基于地图的克隆在 CHY1 揭示了一个胡说八道变化,它编码 CoA hydrolase 为缬氨酸分解代谢和丰满的酸氧化需要的 peroxisomal -hydroxyisobutyryl (HIBYL ) 。我们的结果在冷应力发信号为 peroxisomal 新陈代谢建议一个角色,并且种忍耐到冷应力和导致黑暗的饥饿。 | Chun-Hai Dong Bethany K. Zolman Bonnie Bartel Byeong-ha Lee Becky Stevenson Manu Agarwal Jian-Kang Zhu | 2009 | Molecular Plant2009，2，1： | 4 |
| 18 | Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets显示文摘 | Benjamin P. Lewis Christopher B. Burge David P. Bartel | 2005 | Cell2005，，1： | 4 |
| 19 | MicroRNAs: Target Recognition and Regulatory Functions显示文摘 | David P. Bartel | 2009 | Cell2009，，2： | 4 |
| 20 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
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