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| 1 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 2 | Cow manure and cow manure-derived biochar application as a soil amendment for reducing cadmium availability and accumulation by Brassica chinensis L. in acidic red soil显示文摘Organic amendment is a promising,in situ phytostabilization approach to alleviate the phytotoxic effects of heavy metal contaminated soils.The aim of this study was to evaluate the feasibility of cow manure(CM)and its derived biochar(CMB)as a soil amendment on cadmium(Cd)availability and accumulation in low and high Cd-accumulating cultivars of Brassica chinensis L.grown in an acidic red soil.CM and CMB were applied to Cd-contaminated acidic red soil at the rates of 0,3.0and 6.0%(w/w).Application of CMB was significantly more effective than that of CM,as it reduced the availability of Cd in soil by 34.3–69.9%and its bioaccumulation in the low Cd accumulator,Aijiaoheiye 333,by 51.2 and 67.4%,respectively.The addition of CMB significantly increased the extractability and accumulation of trace metals(Zn,Mn,Fe,and Cu)by plants and improved plant biomass production.CMB application,combined with utilizing low Cd accumulating cultivars represents a new,sustainable strategy to alleviate the toxic effects on Cd and improve food safety. | Yasmin Khan Kiran Ali Barkat CUI Xiao-qiang FENG Ying PAN Feng-shan TANG Lin YANG Xiao-e | 2017 | Journal of Integrative Agriculture2017，16，3： | 8 |
| 3 | Dubin-Johnson syndrome with systemic lupus erythematosus: a case report显示文摘BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated systematically including review of history, physical examination for the stigmata of chronic liver disease, and other investigations. RESULT: Liver biopsy revealed a black liver with preserved architecture suggestive of DJS. CONCLUSIONS: SLE may develop in DJS. The relationship between DJS and SLE in this case is most likely a chance occurrence. | Mamun-Al Mahtab Md. Fazal Karim Salimur Rahman Abul Barkat Muhammad Adnan | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 6 |
| 4 | An update on the 2014 Ebola outbreak in western Africa显示文摘The recent Ebola outbreak in Western Africa was the most devastating outbreak witnessed in recent times,There have been remarkable local and international efforts to control the crisis,Ebola Virus Disease is the focus of immense research activity,The progression of events in the region has been evolving swiftly and it is of paramount importance to the medical community to be acquainted with the situation,Over 28 000 people were inflicted with the condition,over 11 000 have died,Novel data has emerged regarding modes of transmission,providing rationale for recent flare-ups,Similarly,studies on survivors are elucidating the later stages of the disease recovery process,Novel techniques for diagnosis are also discussed,Finally,the current research regarding treatment and vaccine development is reviewed,particularly the implementation of r VSV-ZEBOV vaccination programs. | Haaris A.Shiwani Rebabonye B.Pharithi Barkat Khan Christian Binoun-A-Egom Peter Kruzliak Vincent Maher Emmanuel Eroume-A Egom | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 6 |
| 5 | e-antigen-negative chronic hepatitis B in Bangladesh显示文摘BACKGROUND:Bangladesh is a densely populated country where about 10 million people are chronically infected with hepatitis B virus(HBV).The aim of the present study was to evaluate the biochemical,virological and histological characteristics of HBeAg-negative chronic hepatitis B(CHB). METHODS:Patients were included in this study if they were chronically infected with HBV with detectable DNA.The patients who were co-infected with human immunodeficiency virus,hepatitis delta virus or hepatitis C virus,and previously subjected to antiviral treatment,and those with hepatocellular carcinoma were excluded.The study was conducted during the period of January 2001 to December 2007.During this period 2617 patients with CHB were studied.HBeAg-positive cases were included to compare the characteristics.Among them,237 cases underwent liver biopsy. RESULTS:2296 patients(87.7%)were male,with a mean age of 28.9±13.7 years.2375 patients(90.8%)had CHB,and 242(9.2%)were cirrhotic.HBV DNA levels were 7.6±1.5 copies/ml,ALT was 111.3±212.5 U/L,and AST was 91.5± 148.9 U/L.The number of HBeAg-negative CHB cases was 1039(39.7%).HBeAg-negative patients with a lower DNA load were older,and they had more fibrotic changes in the liver than HBeAg-positive patients.The two groups did not differ in necroinflammatory activity,but the former had lower ALT and AST values.Cirrhosis was more common in e-antigen-negative patients.CONCLUSIONS:e-antigen-negative CHB patients are older and have more hepatic fibrosis patients than HBeAg-positive patients,although they have similar necroinflammatory activity. | Nooruddin Ahmad Shahinul Alam Golam Mustafa Abul Barkat Muhammad Adnan Rahat Hasan Baig Mobin Khan | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 6 |
| 6 | Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer显示文摘The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the globe.In many cases,BC becomes resistant to chemotherapy,radiation and hormonal therapies.Traditional BC therapies are associated with adverse side effects,drug resistance and recurrence.Extensive research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against BC.We have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo models.We have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC miRNAs.Finally,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed. | Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 3 |
| 7 | Near-field multiple source localization by passive sensor array显示文摘 | HUANG Y D BARKAT M | 1991 | IEEE Trans Antennas and Propagation1991，39，7： | 2 |
| 8 | Near-field multiple sources localization by passive sensor array显示文摘 | Huang Y D Barkat M | 1991 | IEEE Trans on Antennas and Propagation1991，39，7： | 1 |
| 9 | Near-Field Multiple Source Localization by Passive Sensor Array 显示文摘 | HUANG Y-D BARKAT M | 1991 | IEEE Trans Antennas and Propagation1991，39，7： | 1 |
| 10 | Near-field multiple sources localization by passive sensor array显示文摘 | YD Huang M Barkat | 1991 | IEEE Trans Antennas and Propagation1991，39，7： | 1 |
| 11 | Optimization of Grasping Forces in Handling of Brittle Objects 显示文摘 | Barkat B Zeghloul S Oazeau J P | 2009 | Robotics and Autonomous Systems2009，57，46： | 1 |
| 12 | Neuronal transfer of the human Cu/Zn superoxide dismutase gene increases the resistance of dopaminergic neurons to 6-hydroxydopamine显示文摘 | Barkats M Millecamps S Bilang-Bleuel A | 2002 | J Neurochem2002，82，1： | 1 |
| 13 | Kinetics and thermodynamics studies of chromium(Ⅵ)ions adsorption onto activated carbon from aqueous solutions显示文摘 | Barkat M Nibou D Chegrouche S | 2009 | Chemical Engineering and Processing2009，48，： | 1 |
| 14 | Kinetics and thermodynamics studies of chromium(VI) ions adsorption onto activated carbon from aqueous solutions显示文摘 | Barkat M Nibou D Chegrouche S | 2009 | Chemical Engineering and Processing2009，48，1： | 1 |
| 15 | Near-field multiple sources localization by passive sensor array显示文摘 | Huang Y D Barkat M | 1991 | IEEE Trans Antennas Propagation1991，39，7： | 1 |
| 16 | CFAR Detection for Multiple Target Situations显示文摘 | BARKAT M HIMONAS S D VARSHNEY P K | | 0，，05： | 1 |
| 17 | Automatic censoring CFAR detector based on ordered data variability for nonhomogeneous environments 显示文摘 | Farrouki A Barkat M | 2005 | IEE Proc-R2005，152，1： | 1 |
| 18 | Near-field Multiple Sources Localization by Passive Sensor Array显示文摘 | Huang Y D Barkat M | 1991 | IEEE Trans Antennas and Modeling Propagation1991，39，7： | 1 |
| 19 | Design of higher order polynomial Wigner-ViUe distributions显示文摘 | Barkat B Boashash B | 1999 | IEEE Transactions on Signal Processing1999，47，9： | 1 |
| 20 | Kinetics and ther- modynamics studies of chromium (VI) ions adsorption onto activated carbon from aqueous solutions 显示文摘 | Barkat M Nibou D Chegrouche S | 2009 | Chemical Engi- neering and Processing2009，48，1： | 1 |
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