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| 1 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 2 | 《Science》杂志发表关于计算社会科学的文章:Computational Social Science显示文摘计算科学是一门正在兴起的综合性学科,它依赖于先进的计算机及计算技术对理论科学、大型实验、观测数据、应用科学、国防以及社会科学进行模型化、模拟与仿真、计算等。特别是对极复杂系统进行模型与程序化,然后利用计算机给出严格理论及实验无法达到的过程数据或者直接模拟出整个复杂过程的演变或者预测过程的发展趋势。对基础科学、应用科学、国防科学、社会科学以及工程技术等的发展有着不可估量的科学作用与经济效益。其中,随着信息化和网络化的不断普及与深入,社会动态变化的速度和规模已经提高到一个前所未有的水平,计算科学在社会科学中的深入应用,即计算社会科学也将成为科研信息化发展中一个新的热点。本刊对《Science》2009年2月发表的一篇关于计算社会科学的文章《Computational Social Science》进行了摘编,该文由美国多个大学及研究机构的共15名研究人员共同编写,文章从计算社会科学的数据获取、研究方法及其制约因素,以及人才的培养等几个方面,描述了计算社会科学的发展、讨论了社会科学研究的特点等。其主要目的是想借此文向广大读者介绍计算社会科学这一学科理念,推动这一对于提高社会科学研究水平和规范性的研究方法在国内的发展,并以此进一步繁荣我国社会科学研究工作。 | 张鉴 孔丽华 David Lazer Alex Pentland Lada Adamic Sinan Aral Albert-László Barabási Devon Brewer Nicholas Christakis Noshir Contractor James Fowler Myron Gutmann Tony Jebara Gary King Michael Macy Deb Roy Marshall Van Alstyne | 2010 | 科研信息化技术与应用2010，0，2： | 5 |
| 3 | Evolution of the social network of scientific collaborations显示文摘 | A.L Barabási H Jeong Z Néda E Ravasz A Schubert T Vicsek | 2002 | Physica A: Statistical Mechanics and its Applications2002，，3： | 3 |
| 4 | Impact of proteolytic enzymes in colorectal cancer development and progression显示文摘Tumor invasion and metastasis is a highly complicated, multi-step phenomenon. In the complex event of tumor progression, tumor cells interact with basement membrane and extracellular matrix components. Proteolytic enzymes(proteinases) are involved in the degradation of extracellular matrix, but also in cancer invasion and metastasis. The four categories of proteinases(cysteine-, serine-, aspartic-, and metalloproteinases) are named and classified according to the essential catalytic component in their active site. We and others have shown that proteolytic enzymes play a major role not only in colorectal cancer(CRC) invasion and metastasis, but also in malignant transformation of precancerous lesions into cancer. Tissue and serumplasma antigen concentrations of proteinases might be of great value in identifying patients with poor prognosis in CRC. Our results, in concordance with othersindicate the potential tumor marker impact of proteinases for the early diagnosis of CRC. In addition, proteinases may also serve as potential target molecules for therapeutic agents. | László Herszényi Loránd Barabás István Hritz Gábor István Zsolt Tulassay | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 5 | Design-Based Research: Putting a Stake in the Ground显示文摘 | Sasha Barab Kurt Squire | 2004 | Journal of the Learning Sciences2004，，1： | 2 |
| 6 | Emergence of scaling in random networks显示文摘 | Albert-László Barabási and Réka Albert | 1999 | Science1999，286，5439： | 1 |
| 7 | Statistical mechanics of com-plex networks显示文摘 | Albert R Barabási A L | 2002 | Reviews of Modern Physics2002，74，1： | 1 |
| 8 | Evolution of the socialnetwork of scientific collaborations显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physical A1999，，： | 1 |
| 9 | Mean-field theory for scale-free random networks显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physica A1999，，272： | 1 |
| 10 | Design-Based Research: Putting a Stake in the Ground显示文摘 | Sasha Barab & Kurt Squire | 2004 | The Journal of the Learning Science2004，13，1： | 1 |
| 11 | Understanding individual human mobility patterns显示文摘 | Gonzá lez M C Hidalgo C A Barabá si A L | 2008 | Nature2008，453，7196： | 1 |
| 12 | Emergence of Scaling in Random Networks显示文摘 | Barabási A -L Albert R | 1999 | Science1999，286，： | 1 |
| 13 | Emergence of scaling in random networks显示文摘 | Albert-László Barabási Réka Albert | 1999 | Science1999，286，： | 1 |
| 14 | The Diameter of the world wide web显示文摘 | Albert R Jeong H Barabási A-L | 1999 | Nature1999，401，： | 1 |
| 15 | Statistical Mechanics of Complex Networks显示文摘 | Albert R Barabási A L | 2002 | Reviews of Modern Physics2002，74，1： | 1 |
| 16 | Emergence of scaling in random networks 显示文摘 | Barabáisi A Albert R | 1999 | Science1999，286，5439： | 1 |
| 17 | Controllability of Complex Networks显示文摘 | Liu Y Y Slotine J J Barabási A L | 2011 | Nature2011，473，7346： | 1 |
| 18 | Statistical mechanics of complex networks显示文摘 | Albert R Barabási A L | 2002 | Review of Modern Physics2002，74，1： | 1 |
| 19 | Mean-field theory for scale-free random networks显示文摘 | BARAB(A)SI A L ALBERT R JEONG H | 1999 | Physica A Statistical Mechanics and its Applications1999，272，12： | 1 |
| 20 | Diameter of the World-Wide Web显示文摘 | Réka Albert Hawoong Jeong Barabási A-L | 1999 | Nature1999，401，： | 1 |
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