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| 1 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | Spliner as embeddings for generalized cylinders显示文摘 | Shani U Ballard P H | 1984 | Computer Vision Graphics and Image Processing1984，27，： | 2 |
| 3 | chronic Parkinsonism in human due to aproduct of meperidine-analog synthesis 显示文摘 | Langston J W Ballard P Tetrud J W | 1983 | Science1983，219，4587： | 1 |
| 4 | Discovery of azd8931, an equipotent, reversible inhibitor of signaling by egfr, HER2, and HER3 receptors 显示文摘 | BARLAAM B ANDERTON J BALLARD P | 2013 | ACS Med Chem Lett2013，4，8： | 1 |
| 5 | Controlling a computer via facial aspect 显示文摘 | Ballard P Stockman G C | 1996 | IEEE Transactiones on Systems Man and Cybenetics1996，25，4： | 1 |
| 6 | Parkinsonism induced byl- Methyl-4- phenyl-1, 2, 3, 6-tetrahydropyridine ( MPTP ) : implications for treatment and the pathogenesis of Parkinson's disease显示文摘 | LANGSTON J W BALLARD P | 1984 | Neuro Sci1984，11，： | 1 |
| 7 | Direct detection of vanB2 using the Roche LightCycler vanA/B detection assay to indicate vancomycin-resistant enterococcal carriage-sensitive but not specific 显示文摘 | YOUNG H L BALLARD P GRAYSON M L | 2007 | J Antimicrob Chemother2007，59，4： | 1 |
| 8 | Physical study of laser-produced plasma in confined geometry显示文摘 | FABBRO R FOURNIER J BALLARD P DEVAUX D VIRMONT J | 1990 | Journal of Applied Physics1990，68，2： | 1 |
| 9 | Comparison of corn silage hybrids for yield,nutrient composition,in vitro digestibility,and milk yield by dairy cows显示文摘 | Thomas E D Mandebvu P Ballard C S | 2001 | Journal of Animal Science2001，84，： | 1 |
| 10 | Predictive coding in the visual cortex:a functional interpretation of some extra-classical receptive-field effects 显示文摘 | RAO R P N BALLARD D H | 1999 | Nature Neuroscience1999，2，1： | 1 |
| 11 | A taxonmic revision of Collinsonia (Lamiaceae) based on phenetic analyses of morphological variation显示文摘 | Peirson J A Cantion P D Ballard H E | 2006 | Systematic Botany2006，31，2： | 1 |
| 12 | MRI in vitamin B12 defi- ciency myelopathy 显示文摘 | Locatelli ER Laureno R Ballard P | 1999 | Can J Neurol Sci1999，26，： | 1 |
| 13 | Mitochondrial DNA content of mature spermatozoa and oocytes in the genetic model Drosophila 显示文摘 | Wolff JN Sutovsky P Ballard JW | 2013 | Cell Tissue Res2013，353，1： | 1 |
| 14 | Physical study of laser-produced plasma in confined geometry 显示文摘 | FABBRO R FOURNIER J BALLARD P | 1990 | Journal of Applied Physics1990，68，2： | 1 |
| 15 | Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine显示文摘 | Langston J W Ballard P A Jr | | 0，，05： | 1 |
| 16 | Depression in Parkinson disease-epidemiology,mechanisms and management显示文摘 | Aarsland D P hlhagen S Ballard C G | 2012 | Nature Reviews Neurology2012，8，1： | 1 |
| 17 | Physical study of laser-produced plasma in confined geometry显示文摘 | FABBRO R FOURNIER J BALLARD P | 1990 | Journal of Applied Physics1990，68，2： | 1 |
| 18 | Effect of feeding calcium salts of long-chain fatty acids,from palm fatty acid distillate or soybean oil, to high producing dairy cows on milk yield and composition, and on selected blood and reproductive parameters 显示文摘 | Mandebvu P Ballard C S Sniffen C J | 2003 | Animal Feed Science and Technology2003，108，14： | 1 |
| 19 | Chronic parkinsonism in humans due to a product of meperidine-analog synthesis显示文摘 | Langston JW Ballard P Tetrud JW | 1983 | Science1983，219，4587： | 1 |
| 20 | Chronic Parkinsonism in human due to product of mepefidine-analog synthesis 显示文摘 | Langton JW Ballard P Tetrud JW | 1983 | Science1983，219，4587： | 1 |
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