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| 1 | Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis显示文摘Patients with indeterminate colitis(IC) are significantly younger at diagnosis with onset of symptoms before the age of 18 years with significant morbidity in the interim. The successful care of IC is based on microscopic visual predict precision of eventual ulcerative colitis(UC) or Crohn's colitis(CC) which is not offered in 15%-30% of inflammatory bowel disease(IBD) patients even after a combined state-of-the-art classification system of clinical, visual endoscopic, radiologic and histologic examination. These figures have not changed over the past 3 decades despite the introduction of newer diagnostic modalities. The patient outcomes after restorative proctocolectomy and ileal pouch-anal anastomosis may be painstaking if IC turns into CC. Our approach is aiming at developing a single sensitive and absolute accurate diagnostic test tool during the first clinic visit through endoscopic biopsy derived proteomic patterns. Matrix-assisted-laser desorption/ionization mass spectrometry(MS) and/or imaging MS technologies permit a histology-directed cellular test of endoscopy biopsy which identifies phenotype specific proteins, as biomarker that would assist clinicians more accurately delineate IC as beingeither a UC or CC or a non-IBD condition. These novel studies are underway on larger cohorts and are highly innovative with significances in differentiating a UC from CC in patients with IC and could lend mechanistic insights into IBD pathogenesis. | Billy Ray Ballard Amosy Ephreim M'Koma | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 7 |
| 2 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 3 | Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c - IAP2 is under NF-kappa B control 显示文摘 | Chu Z L Mckinsey T A Lia L Gentry J J Malim M H Ballard D W | 1997 | PNAS1997，94，10： | 1 |
| 4 | Impacts of forest management on northern forest soils显示文摘 | Ballard T M | 2000 | Forest Ecology and Management2000，133，： | 1 |
| 5 | 显示文摘 | Capema T J R G Campbell M R M Ballard | 1995 | J Nutr1995，125，： | 1 |
| 6 | Color indexing显示文摘 | Swain M J Ballard D H | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 7 | Color indexing显示文摘 | Swain M J Ballard D H | 1991 | Inter- national Journal of Computer Vision1991，7，1： | 1 |
| 8 | Color Indexing 显示文摘 | Swain M J Ballard D H | 1991 | International Journal of Computer Vision(S0920-5691)1991，7，1： | 1 |
| 9 | Color indexing 显示文摘 | Swain M J Ballard D H | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 10 | Color Indexing显示文摘 | Ballard D H | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 11 | Concurrent analy- sis of nose and groin swab specimens by the IDI-MRSA PCR assay is comparable to analysis by individual-specimen PCR and routine culture assays for detection of colonization by methicillin-resistant Staphylococcus aureus 显示文摘 | BISHOP E J GRABSCH S A BALLARD B M | 2006 | J Clin Microbio12006，44，8： | 1 |
| 12 | Malignant phyllodes tumor of the breast:review of the literature and case report of stromal overgrowth显示文摘 | Cuerrero M A Ballard B R Grau A M | 2003 | Surg Oncol2003，12，1： | 1 |
| 13 | Color indexing显示文摘 | Swain M J Ballard D H | 1991 | lnternational Jour- nal of Computer Vision1991，7，1： | 1 |
| 14 | Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth 显示文摘 | Guerrero M A Ballard B R Grau A M | 2003 | Surg Oncol2003，12，： | 1 |
| 15 | Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in milk from Italian women living in Rome and Venice 显示文摘 | Ingelido A M Ballard T Dellatte E | 2007 | Chemosphere2007，67，9： | 1 |
| 16 | Color Indexing显示文摘 | Swain M J Ballard D H | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 17 | Color indexing显示文摘 | D H Ballard | 1993 | Int J Comput Vis1993，26，4： | 1 |
| 18 | Color indexing 显示文摘 | SWAIN M BALLARD D | 1991 | International Journal of Computer Vision1991，7，1： | 1 |
| 19 | Direct detection of vanB2 using the Roche LightCycler vanA/B detection assay to indicate vancomycin-resistant enterococcal carriage-sensitive but not specific 显示文摘 | YOUNG H L BALLARD P GRAYSON M L | 2007 | J Antimicrob Chemother2007，59，4： | 1 |
| 20 | Compari- son of testoster-one metabolism in benign p rostatic hy- perp lasia and human prostate cancer cell lines in vitro 显示文摘 | Smith C M Ballard S A Wyllie M G | 1994 | J Steroid Biochem Mol Biol1994，50，34： | 1 |
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