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| 1 | Chronic constipation in hemiplegic patients显示文摘AIM: To assess the prevalence of bowel dysfunction in hemiplegic patients, and its relationship with the site of neurological lesion, physical immobilization and pharmacotherapy. METHODS: Ninety consecutive hemiplegic patients and 81 consecutive orthopedic patients were investigated during physical motor rehabilitation in the same period, in the same center and on the same diet. All subjects were interviewed ≥ 3 mo after injury using a questionnaire inquiring about bowel habits before injury and at the time of the interview. Patients’ mobility was evaluated by the Adapted Patient Evaluation Conference System. Drugs considered for the analysis were nitrates, angiogenic converting enzyme (ACE) inhibitors, calcium antagonists, anticoagulants, antithrombotics, antidepressants, anti-epileptics. RESULTS: Mobility scores were similar in the two groups. De novo constipation (OR = 5.36) was a frequent outcome of the neurological accident. Hemiplegics showed an increased risk of straining at stool (OR: 4.33), reduced call to evacuate (OR: 4.13), sensation of incomplete evacuation (OR: 3.69), use of laxatives (OR: 3.75). Logistic regression model showed that constipation was significantly and independently associated with hemiplegia. A positive association was found between constipation and use of nitrates and antithrombotics in both groups. Constipation was not related to the site of brain injury. CONCLUSION: Chronic constipation is a possible outcome of cerebrovascular accidents occurring in 30% of neurologically stabilized hemiplegic patients. Its onset after a cerebrovascular accident appears to be independent from the injured brain hemisphere, and unrelated to physical inactivity. Pharmacological treatment with nitrates and antithrombotics may represent an independent risk factor for developing chronic constipation. | F Bracci D Badiali P Pezzotti G Scivoletto U Fuoco L Di Lucente A Petrelli E Corazziari | 2007 | World Journal of Gastroenterology2007，13，29： | 15 |
| 2 | Comparative outcome of stapled trans-anal rectal resection and macrogol in the treatment of defecation disorders显示文摘AIM:To prospectively assess the eff icacy and safety of stapled trans-anal rectal resection(STARR) compared to standard conservative treatment,and whether preoperative symptoms and findings at defecography and anorectal manometry can predict the outcome of STARR.METHODS:Thirty patients(Female,28;age:51 ± 9 years) with rectocele or rectal intussusception,a defecation disorder,and functional constipation were submitted for STARR.Thirty comparable patients(Female,30;age 53 ± 13 years),who presented with symptoms of rectocele or rectal intussusception and were treated with macrogol,were assessed.Patients were interviewed with a standardized questionnaire at study enrollment and 38 ± 18 mo after the STARR procedure or during macrogol treatment.A responder was def ined as an absence of the Rome Ⅲ diagnostic criteria for functional constipation.Defecography and rectoanal manometry were performed before and after the STARR procedure in 16 and 12 patients,respectively.RESULTS:After STARR,53% of patients were responders;during conservative treatment,75% were responders.After STARR,30% of the patients reported the use of laxatives,17% had intermittent anal pain,13% had anal leakage,13% required digital facilitation,6% experienced defecatory urgency,6% experienced fecal incontinence,and 6% required re-intervention.During macrogol therapy,23% of the patients complained of abdominal bloating and 13% of borborygmi,and 3% required digital facilitation.No preoperative symptom,defecographic,or manometric finding predicted the outcome of STARR.Post-operative defecography showed a statistically significant reduction(P < 0.05) of the rectal diameter and rectocele.The postoperative anorectal manometry showed that anal pressure and rectal sensitivity were not significantly modified,and that rectal compliance was reduced(P = 0.01).CONCLUSION:STARR is not better and is less safe than macrogol in the treatment of defecation disorders.It could be considered as an alternative therapy in patients unresponsive to macrogol. | Ivano Biviano Danilo Badiali Laura Candeloro Fortunée Irene Irene Habib Massimo Mongardini Angelo Caviglia Fiorella Anzini Enrico S Corazziari | 2011 | World Journal of Gastroenterology2011，17，37： | 3 |
| 3 | Long term efficacy, safety and tolerability of low daily doses of osmotic polyethylene glycol electrolyte balanced solution ( PMF-100 ) in the treatment of functional chronic constipation显示文摘 | Corazziari E Badiali D Bazzocchi G | 2000 | Gut2000，46，4： | 1 |
| 4 | Gastrointestinal dys function following stroke显示文摘 | Scivoletto G Fuoco U Badiali D | 1997 | J Neurol Sci1997，150，1： | 1 |
| 5 | Gastrointestinal dysfunction following stroke显示文摘 | Scivoletto G Fuoco U Badiali D | 1997 | J Neurol Sci1997，150，： | 1 |
| 6 | Melanosis of the rectum in patients with chronic constipation显示文摘 | BADIALI D | 1985 | Dis Colon Rect1985，28，： | 1 |
| 7 | Melanosis of the rectum in patients with chronic consti-pation显示文摘 | | 1985 | Dis Colon Rect1985，28，4： | 1 |
| 8 | Gastrointestinal Dysfunction Following Stroke显示文摘 | Scivoleno G Fuoco U Badiali D | 1997 | J Neurol Sci1997，150，1： | 1 |
| 9 | Ito cell heterogeneity:desmin-nagative Ito cells in normal rat liver显示文摘 | Ballardini G Groff P Badiali de Giorgi L | | 0，，02： | 1 |
| 10 | Effect of wheat bran in treatment of chronic nonorganic constipation: a double-blind controlled trial显示文摘 | BADIALI D CORAZZIARI E HABIB F I | 1995 | Dig Dis Sci1995，40，2： | 1 |
| 11 | Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation显示文摘 | Corazziari E Badiali D Habib FI Reboa G Pitto G Mazzacea G | 1996 | Dig Dis Sci1996，41，8： | 1 |
| 12 | Relationship between connective tissue cells and fibronectin in a sequential model of experimental hepatic fibrosis显示文摘 | Giovanna Cenacchi Giorgio Ballardini Lucilla Badiali Giorgi Carlo Antonio Busachi Mario Rosso Francesco Bianco Bianchi Graziella Biagini Renzo Laschi | 1983 | Virchows Archiv B Cell Pathology Including Molecular Pathology1983，，1： | 1 |
| 13 | Gastrointestinal Dysfunction Following Stroke显示文摘 | Scivoletto G Fuoco U Badiali D | 1997 | J Neurol Sci1997，150，1： | 1 |
| 14 | 显示文摘 | Vorotyntsev M A Badiali J P Inzelt G | 1999 | J Electroanal Chem1999，472，： | 1 |
| 15 | Gastrointestinal dysfunction following stroke显示文摘 | SCIVOLETTO G FUOCO U BADIALI D | 1997 | J Neurol Sci1997，150，1： | 1 |
| 16 | Melanosis of the rectum in patients with chronic constipation 显示文摘 | Badiali D Marcheggiano A Pallone F | 1985 | Dis Colon Rectum1985，28，4： | 1 |
| 17 | Melanosis of the rectum in patients with chronic constipation显示文摘 | Badiali Detal | 1985 | Dis Colon Rect1985，28，： | 1 |
| 18 | Long term efficacy,safety,and Tolerability of low daily doses of osmotic polyethylene glycol electrolyte balanced solution(PMF-100)in the treatment of functional chronic constipation显示文摘 | Corazziari E Badiali D Bazzocchi G | 2000 | Gut2000，46，4： | 1 |
| 19 | Electrochemical Impedance Spectroscopy of Thin Films with Two Mobile Charge Carriers: Effects of the Interracial Charging 显示文摘 | GOROTYNTSEV M A BADIALI J P INZELT G | 1999 | J Electrochem Chem1999，472，： | 1 |
| 20 | Electrochemical impedance spectroscopy of thin films with two mobile charge carriers effects of the interfacical charging显示文摘 | Votrotyntsev M A Badiali J P Inzeh G | 1999 | J Electroanal Chem1999，472，1： | 1 |
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