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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | Pre-and post-casino impact of residents' perception显示文摘 | Lee C K Back K J | 2003 | Annals of Tourism Research2003，30，4： | 1 |
| 4 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 ( RRMI ) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Lee J J Maeng C H Back S K | 2010 | Lung Cancer2010，70，2： | 1 |
| 5 | Laser-plasma interactions in ignition-scale hohlraum plasmas显示文摘 | MacGOWAN B J AFEYAN B B BACK C A | 1996 | Physics of Plasmas1996，3，5： | 1 |
| 6 | Transanal single port microsurgery (TS PM) as a modified technique of transanal endoscopic microsurgery (TEM)显示文摘 | Lorenz C Nimmesgern T Back M | 2010 | Surg Innov2010，17，2： | 1 |
| 7 | The capabilities and limitations of total flooding, water mist fire suppression systems in machinery space applieations显示文摘 | Back G G Beyler C L Hansen R | 2000 | Fire Technology2000，36，： | 1 |
| 8 | Detailed measurements of a diffusive supersonic wave in a radiatively heated foam显示文摘 | Back C A Bauer J D Landen O L | 2000 | Phys Rev Lett2000，84，2： | 1 |
| 9 | Chiral signatures of chlordanes indicate changing sources to the atmosphere over the past 30 years 显示文摘 | BIDLEMAN T F WONG F BACKE C | 2004 | Atmospheric Environment2004，38，： | 1 |
| 10 | Analysis of heavy-ion fusion reactions at extreme sub-barrier energies显示文摘 | Jiang C L Esbensen H Back B B | 2004 | Phys Rev C2004，69，14： | 1 |
| 11 | Volatile components in flavour concentrates from crayfish processing waste显示文摘 | Cha Y J Back H H Hsieh T C Y | 2006 | Journal of the Science of Food and Agriculture2006，58，2： | 1 |
| 12 | Scalable production of large quantities of defect-free few-layer graphene by shear exfoliation in liquids显示文摘 | Paton K R Varrla E Backes C | 2014 | Nature Materials2014，13，6： | 1 |
| 13 | The results of primary Birmingham hip resurfacings at a mean of five years: an independent prospective review of the first 230 hips显示文摘 | Hing C B Back D L Bailey M | 2007 | J Bone Joint Surg Br2007，89，91： | 1 |
| 14 | Diffusive supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 15 | Locally recurrent globally feedforward networks: a critical review of architec- tures显示文摘 | Tsoi A C Back A D | 1994 | IEEE Transactions on Neural Networks1994，5，2： | 1 |
| 16 | Characterization of nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | BACK C A AUFFMAN R L K BELL P M | 1995 | Review of Scientific Instruments1995，66，1： | 1 |
| 17 | lntermittent intrave- nous sildenafil for pulmonary hypertension management in neonates and infants 显示文摘 | Stultz JS1 Puthoff T Backes C Jr | 2013 | Am Health Syst Pharm2013，70，40： | 1 |
| 18 | Two-year field study shows little evidence that PPO-transgenic rice affects the structure of soil microbial communities显示文摘 | Chun Y J Kim H J Park K W Jeong S C Lee B Back K Kim H M and Kim C G | | 0，，： | 1 |
| 19 | PCB in soils and estimated soil-air exchange fluxes of selected PCB congeners in the south of Sweden 显示文摘 | Backe C Cousins I T Larsson P | 2004 | Environmental Pollution2004，128，1： | 1 |
| 20 | Intra-specifil heterogeneity of the rDNA internal transcribed spacer in the Simulium damnosum (Diptera: Simuliidae) complex显示文摘 | TANG J BACK C | 1996 | Mil Biol Evol1996，13，1： | 1 |
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