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| 1 | Gene set enrichment analysis of alpha-glucosidase inhibitors from Ficus benghalensis显示文摘Objective:To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein molecules.Methods:The phytoconstituents of Ficu.s benghalen.sis were queried for inhibitors of alphaglucosidase,also identified as aldose reductase inhibitors.Druglikeness score,absorption,distribution,metabolism,excretion and toxicity profile,biological spectrum,and gene expression were predicated for each compound.Docking study was performed to predict the binding affinity with alpha-glucosidase and aldose reductase and compared with clinically proven molecules.Kyoto Encyclopedia of Genes and Genomes pathway analysis was performed for the regulated genes to identify the modulated pathways.Results:Apigenin,3,4’,5,7-tetrahydroxy-3’-methoxyflavone,and kaempferol were identified as inhibitors of alpha-glucosidase and aldose reductase.Kaempferol was predicted to possess the highest binding affinity with both targets.The p53 signaling pathway was predicted to modulate the majority of protein molecules in diabetes mellitus.All the alpha-glucosidase inhibitors were also predicted as membrane integrity agonist and anti-mutagenic compounds.Conclusions:The current study indicates alpha-glucosidase inhibitors from Ficus benghale,nsis can act as aldose reductase inhibitors after absorption from the intestinal tract.Furthermore,these phytoconstituents are involved in the regulation of numerous protein molecules and pathways.Hence,the anti-diabetic efficacies of these compounds are due to their action on multiple protein molecules and synergistic effects which should be confirmed by future investigations. | Pukar Khanal B.M.Patil | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，6： | 3 |
| 2 | 包芯纱性能的测试方法显示文摘包芯纱在提升服装价值方面得到了广泛的认可,生产包芯纱有很多方法。为成功生产并将其转变成有用的产品,包芯纱还有许多特性有待测试评估,这些测试方法不同于传统纱线的测试方法,并且缺乏评估性能的标准。阐述了包芯纱的多种性能及其评估方法。 | M.C.Burji P.V.Kadole M.Y.Gudiyawar B.M.Patil 陈杰 | 2013 | 国际纺织导报2013，41，6： | 0 |
| 3 | Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19显示文摘Anthraquinone derivatives are identified for their immune-boosting,anti-inflammatory,and anti-viral efficacy.Hence,the pre-sent study aimed to investigate the reported anthraquinone derivatives as immune booster molecules in COVID-19 infection and evaluate their binding affinity with three reported targets of novel coronavirus i.e.3C-like protease,papain-like protease,and spike protein.The reported anthraquinone derivatives were retrieved from an open-source database and filtered based on a positive druglikeness score.Compounds with positive druglikeness scores were predicted for their targets using DIGEP-Pred and the interaction among modulated proteins was evaluated using STRING.Further,the associated pathways were recorded concerning the Kyoto Encyclopedia of Genes and Genomes pathway database.Finally,the docking was performed using autodock4 to identify the binding efficacy of anthraquinone derivatives with 3C-like protease,papain-like protease,and spike protein.After docking the pose of ligand scoring minimum binding energy was chosen to visualize the ligand-protein interaction.Among 101 bioactives,36 scored positive druglikeness score and regulated multiple pathways concerned with immune modulation and(non-)infectious diseases.Similarly,docking study revealed torososide B to possess the highest binding affinity with papain-like protease and 3C-like protease and 1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6′-O-acetyl)-β-d-xylopyranosyl-(1→2)-β-d-glucopyranoside with spike protein. | Pukar Khanal B.M.Patil Jagdish Chand Yasmin Naaz | 2020 | Natural Products and Bioprospecting2020，10，5： | 0 |
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