| 4 | 妊娠期间口服减充血剂对分娩结局的影响显示文摘Objective: The purpose of this study was to evaluate delivery outcome after maternal use of oral decongestants. Study design: We identified 2474 women who had reported the use of oral decongestants (mainly phenylpropanolamine) during early pregnancy and 1771 women who used prescription oral decongestants later in pregnancy. With Mantel-Haenszel analysis, comparisons were made with all women who gave birth in Sweden. Results: The risk ratio for any congenital malformation after the use of oral decongestants was 0.96 (95% CI, 0.80- 1.16). Women who were prescribed decongestants after the first antenatal visit less often than expected had infants who were born preterm (odds ratio, 0.68; 95% CI, 0.52- 0.88), of low birth weight (odds ratio, 0.53; 95% CI, 0.37- 0.77), small-for-date (odds ratio, 0.71; 95% CI, 0.47- 1.08), or perinatally dead (odds ratio, 0.53; 95% CI, 0.22- 12.5). Conclusion: No teratogenic effect of oral decongestants was found. An association found between the late pregnancy use of such drugs and a favorable neonatal outcome can be explained hypothetically by the postulated association between pregnancy rhinitis and plaal hormones. | Kllén B.A.J. Otterblad Olausson P. 朱国栋 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 0 |
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