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| 1 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 2 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 3 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 4 | The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia显示文摘Objective:To generate life table characteristics for the dengue vector Aedes albopictus(A. albopictus) under uncontrolled conditions,incorporating both the aquatic and the adult stages. Methods:Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice.774 eggs were hatched in seasoned water.F1 larvae were followed for development until their F2 counterparts emerged as adults.Some population parameters were monitored(Fl) or estimated(F2).Results:A.albopictus exhibited increased fecundity and egg hatch success. Immature development was quick.Immature survival was high,with lowest rate in the pupal stage.Adult emergence was about 81%and sex ratio was close to 1:1.Generational mortality(K) was about 28%.A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.Conclusios:It can be concluded that natural A.albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition. | H Nur Aida Hamady Dieng Abu Hassan Ahmad Tomomitsu Satho AT Nurita MR Che Salmah Fumio Miake B Norasmah | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 2 |
| 5 | Monochromatic excimer light (308 nm) : an immunohistochemical study of cutaneous T cells and apoptosis related molecules in psoriasis显示文摘 | Bianchi B Campolmi P Mavilia L et at | 2003 | J Eur Acad Dermatol Venereol2003，17，： | 1 |
| 6 | VersicanV2 and the central inhibitory domain of Nogo - A inhibit neurite growth via p75NTR/NgR- independent pathways that converge at RhoA 显示文摘 | Schweigreiter R Walmsley AR Niederost B et at | 2004 | J Mol Cell Neurosci2004，27，2： | 1 |
| 7 | Fusion cross-sections for inertial fusion energy 显示文摘 | Li X Z Liu B Chen S el at | 2004 | Laser and Particle Beam2004，22，： | 1 |
| 8 | Solitary fibrous tumor of the orbit: clinical, radiological, histological findings and differential diagnosis of an uncommon tumor显示文摘 | Kordic H Bode-Lesniewska B Pangalu At | 2012 | Klin Monbl Au- genheilkd2012，229，4： | 1 |
| 9 | Pathogen- induced chemokine secretion from model intestinal epi- thelium is inhibited by lipoxin A4 analogs显示文摘 | Gewirtz AT McCormick B Neish AS | 1998 | J Clin In- vest1998，101，9： | 1 |
| 10 | Pathways of load-induced cartilage damage causing cartilage degeneration in the knee after meniscectomy显示文摘 | Wilson W van-Riethergen B van-Donkelaar C C et at | 2003 | J Biomech2003，36，6： | 1 |
| 11 | Association of sequences in the coat protein/read through domain of potato mop-top virus with transmission of Spongospora subterranean显示文摘 | Reavy B Arif M Cowan G H at al | 1998 | Journal of General Virology1998，79，10： | 1 |
| 12 | Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus显示文摘 | Sallmon H Weber SC Huning B et at | | 0，，03： | 1 |
| 13 | Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas显示文摘 | Zhong X U Y Peng F Huang B Lin J Zhang W et at | 2007 | Int J Cancer2007，121，10： | 1 |
| 14 | Epidemiolo- gy and outcomes of ventilator- associated pneumonia in northern Brazil: an analytical descriptive prospective cohort study 显示文摘 | Resende MM Monteiro SG Callegari B el at | 2013 | BMC Infectious Diseases2013，13，： | 1 |
| 15 | Perioperative use of TandemHeart percuta- neous ventricular assist device in surgical repair of postinfaretion ventrieular sep- tal defect显示文摘 | Gregoric ID Kar B Mesar T et at | 2014 | ASAIO J2014，60，5： | 1 |
| 16 | Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papilloma- vires infection 显示文摘 | Li B Hu Y Ye F et at | 2010 | Int J Gynecol Cancer2010，20，4： | 1 |
| 17 | Large eddy simulation of a hydrogen-fueled scramjet combustor with dual cavity显示文摘 | Wang H B Wang Z G Sun M B et at | 2015 | Acta Astronautica2015，108，： | 1 |
| 18 | Effects of salicylic acid and cold on freezing tolerance in winter wheat leaves 显示文摘 | Ta?gín E Atící ? Nalbanto?lu B | 2003 | Plant Growth Regulation2003，41，3： | 1 |
| 19 | Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers显示文摘 | Ates I Suzen HS Yucesoy B | 2008 | American Journal Of Industrial Medicine2008，51，10： | 1 |
| 20 | Spectroscopic Ellipsometry of Metal Phthalocyanine Thin Films 显示文摘 | DjuriSic A B Kwong C Y Lau T W et at | 2003 | Applied Optics2003，42，31： | 1 |
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