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| 1 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 2 | TWO NEW OLEANOLIC ACID SAPONINS FROM ASTER YUNNANENSIS显示文摘TWONEWOLEANOLICACIDSAPONINSFROMASTERYUNNANENSIS￥YuSHAO;BingNanZHOU;LongZeLINandGeoffreyA.Cofdell(ShanghaiinstituteofMatstheMe... | Yu SHAO Bing Nan ZHOU Long Ze LIN and Geoffrey A. Cofdell (Shanghai institute of Matsthe Medica, Academic Sinica, Shanghai 2O0031 Program for Collaborative research in the Pharmaceutical Sciences, Coilege of pharmacy,Unlversity of lllinois at Chicago, I | 1994 | Chinese Chemical Letters1994，5，10： | 2 |
| 3 | Vascular endothelial function in patients with slow coronary flow显示文摘 | Sezgin AT Sigirci A Barutcu I | 2002 | Coronal Artery Dis2002，14，2： | 1 |
| 4 | Effects of different doses of adrenocorticotrophic hormone on the serum lipoprotein profile in healthy subjects 显示文摘 | Rafnsson AT Johannsson M Olafsson I | 2005 | Basic Clin Pharmacol Toxicol2005，97，2： | 1 |
| 5 | Revised classification scheme of phytoplasmas based on RFL panalyses of 16S rRNA and ribosomal protein gene sequences 显示文摘 | Lee I M Gundersen R D E Davis R E et at | 1998 | Int J Syst Acteriology1998，48，： | 1 |
| 6 | Tectonic subsid- ence modelling and Gondwana source rock hydrocarbon po- tential, Northwest Bangladesh modelling of Kuchma, Singra and Hazipur wells 显示文摘 | Frielingsdorf J Aminul I S Block M et at | 2008 | Marine and Petroleum Geology2008，25，6： | 1 |
| 7 | Imatinib (STI571) for Metastatic Gastrointestinal Stromal Tumours (GIST)显示文摘 | van Oosterom AT Judson I Verweij J | 2001 | Lancet2001，358，： | 1 |
| 8 | Calcineurin inhibitor avoidance versus steroid avoidance following kidney transplantation:Postoperative complications显示文摘 | Shaffer D Kizilisik AT Feurer I | | 0，，10： | 1 |
| 9 | Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers显示文摘 | Ates I Suzen HS Yucesoy B | 2008 | American Journal Of Industrial Medicine2008，51，10： | 1 |
| 10 | Efficient oxidative folding of conotoxins and the radiation of venomous cone snails 显示文摘 | Bulaj G Buczek O Goodsell I el at | 2003 | Proe Nad Aead Sei USA2003，100，14： | 1 |
| 11 | Direct Neurotoxicity of Tetraeaine on Growth Cones and Neurites of Growing Neurons in Vitro显示文摘 | Saito S Radwan I I Obata H et at | 2001 | Anesthesiology2001，95，3： | 1 |
| 12 | A 40 degrees gaze down position for pneumatic displacement of submaeular hemorrhage:clinical application and results 显示文摘 | LINCOFF H KREISSIG I STOPA M et at | 2008 | Retina2008，28，1： | 1 |
| 13 | Application of alpha-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma显示文摘 | Epivatianos A Poulopoulos A Dimitrakopoulos I et at | 2007 | Oral Oncol2007，43，1： | 1 |
| 14 | Open reading frame 2 of porcine circovirus type 2 encodes a major eapsid protein 显示文摘 | Nawagitgul P Morozov I Bolin S R et at | 2000 | J Gen Virol2000，81，： | 1 |
| 15 | Trimetazidine may protext the myocardium during cardiac surgery 显示文摘 | Iskesen I Kurdal AT Eserdag M | 2009 | Heart Surg Forum2009，12，3： | 1 |
| 16 | Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat显示文摘 | Ocaranza MP Godoy I Jalil JE et at | 2006 | Hypertension2006，48，4： | 1 |
| 17 | Evaluation of the an- timicrobial activities of plant oxylipins supports their in-volvement in defense against pathogens 显示文摘 | Prost I Dhondt S Rothe G et at | 2005 | Plant Physi- ology2005，139，4： | 1 |
| 18 | Antibacterial furofuran lignans from Canary Islands propolis 显示文摘 | Christov R Bankova V Tsvetkova I et at | 1999 | Fitoterapia1999，70，6： | 1 |
| 19 | Plasma nitric oxide level and its role in slow coronary flow phenomenon显示文摘 | Sezgin N Barutcu I Sezgin AT | 2005 | Int Heart J2005，46，3： | 1 |
| 20 | The three-dimensional map of microsomal glutathione transferase 1 at 6A resolution显示文摘 | SCHMIDT-KREY I MITSUOKA K HIRAI T et at | 2000 | EMBO J2000，19，23： | 1 |
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