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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Rock fracture toughness determination by the Brazilian test显示文摘 | Guo H Aziz I Schmidt L C | 1993 | Engineering Geology1993，33，2： | 1 |
| 3 | A homogeneous model for gas-liquid flow in horizontal wells显示文摘 | Ouyang L B Aziz K | 2000 | Journal of Petroleum Science and Engineering2000，27，3： | 1 |
| 4 | Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective pro-tection of phenolic functions 显示文摘 | Mohamed B Stephane L Aziz A | 2002 | Tetrahedron2002，58，10： | 1 |
| 5 | Compositional modeling with an equation of state 显示文摘 | Nghiem L X Fong D K Aziz K | 1981 | Society of Petroleum Engineering Journal1981，21，12： | 1 |
| 6 | Use of Voronoi Grid in Reservoir Sim- ulation显示文摘 | Palagi C L Aziz K | 1994 | SPE Advanced Technology Series1994，2，2： | 1 |
| 7 | Hemisynthesis of all the O-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions 显示文摘 | Mohamed B Stephane L Aziz A | 2002 | Tetrahedron2002，58，10： | 1 |
| 8 | Ovarian torsion in children:is oophorectomy necessary?显示文摘 | Aziz D Davis V Allen L | 2004 | J Pediatr Surg2004，39，5： | 1 |
| 9 | Dietary Starch Type Affects Body Weight and Glycemic Control in Freely Fed but Not Energy-Restricted Obese Rats显示文摘 | Aziz A A Kenney L S Goulet B Abdel-Aal E S | 2009 | Journal of Nutrition2009，139，10： | 1 |
| 10 | Rock fracture toughness determination by the Brazilian test显示文摘 | GUO H AZIZ N I SCHMIDT L C | 1993 | Engineering Geology1993，33，3： | 1 |
| 11 | A single-phase wellbore-flow model for horizontal,vertical and slanted wells显示文摘 | Ouyang L B Arbabi S Aziz K | 1998 | SPEJ1998，3，2： | 1 |
| 12 | A simplified approach to couple wellbore flow and reservoir inflow for arbitrary well configurations显示文摘 | Ouyang L Aziz K | 1998 | SPE489361998，，： | 1 |
| 13 | Reduction of fungi and mycotoxins formation in seeds by gamma irradiation 显示文摘 | Aziz N H Moussa L A A | 2004 | Journal of Food Safety2004，24，2： | 1 |
| 14 | Analytical performance of a highly sensitive C-reactive protein-based immtmoassay and the effects of laboratory variables on levels of protein in blood显示文摘 | Aziz N Fahey J L Detels R | 2003 | Clin Diagtt Lab Immunol2003，10，4： | 1 |
| 15 | c - Met is a prognos- tic markerand potential therapeutic target in clear cell renal cell carcinoma显示文摘 | GIBNEY G T AZIZ S A CAMP R L | 2013 | Ann Oncol2013，24，2： | 1 |
| 16 | Plasmacytoma in the breast with axillary lymph node involvement: a case report显示文摘 | Taylor L Aziz M Klein P | 2006 | Clin Breast Cancer2006，7，1： | 1 |
| 17 | Information Processing in the Mirror Neuron System in Primates and Machines显示文摘 | Demiris Y Aziz - Zadeh L Bonaiuto J | 2014 | Neuroinfor- matics2014，12，： | 1 |
| 18 | General wellbore flow model for horizontal, vertical, and slanted well completions 显示文摘 | Ouyang L Arbabi S Aziz K | 1998 | SPE Journal1998，3，2： | 1 |
| 19 | Optimization of non- conventional well type,location, and trajectory显示文摘 | YETEN B DURLOFSKY L J AZIZ K | 2003 | SPE Jour- nal2003，8，3： | 1 |
| 20 | Kainate acid lesions of the pedunculopontine region in the normal behaving primate 显示文摘 | Munro-Davies L Winter J Aziz TZ | 2001 | Mov Disord2001，16，： | 1 |
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