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| 1 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Effect of microsurgical varieoeeleetomy on human sperm chromatin and DNA integri- ty: a prospective trial显示文摘 | Zini A Azhar R Baazeem A | 2011 | Int J Androl2011，34，1： | 1 |
| 4 | Effect of carrageenan on yield and properties of tofu显示文摘 | A Abd Karim G.A Sulebele M.E Azhar C.Y Ping | 1999 | Food Chemistry1999，，2： | 1 |
| 5 | Comparison of class B scavenger receptors, CD36 and scavenger receptor B I ( SR-B I ), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-B I exhibits a unique enhancement of cholesteryl ester uptake显示文摘 | Connelly M A Klein S M Azhar S | 1999 | J Biol Chem1999，274，1： | 1 |
| 6 | Assessment of de- pression and anxiety in haematological cancer patients and their relationship with quality of llfe显示文摘 | Priscilla D Hamidin A Azhar MZ | 2011 | East Asian Arch Psy- chiatry2011，21，3： | 1 |
| 7 | Clinical features and out- come of sporadic colorectal carcinoma in young patients: a cross sectional analysis form a developing country显示文摘 | Zahir MN Azhar EM Rafiq S et a l | 2014 | ISRN 0ncol2014，20，14： | 1 |
| 8 | Sonication effect on potato starch and sweet potato power 显示文摘 | Azhar A Hamdy M K | 1979 | Journal of Food Science1979，44，3： | 1 |
| 9 | Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells显示文摘 | Turner N A Xia F Azhar G | 1998 | J Mol Cell Cardiol1998，30，： | 1 |
| 10 | Osteoporosis: prevention and impli- cations for social work practice and practice and policy 显示文摘 | Lawrence S A Azhar A | 2010 | Soc Work Public Health2010，25，9： | 1 |
| 11 | A novel mulation in the Lipase H gene underlies autosomal recessive hypotrichosis and woolly hair显示文摘 | Tariq M Azhar A Baig SM | 2012 | Sci Rep2012，2，： | 1 |
| 12 | On the Measurement of Trade Induced Adjustment 显示文摘 | AZHAR A K ELLIOTY R | 2003 | Review of World Economics2003，，3： | 1 |
| 13 | An overview on doubly fed induction generators' controls and contributions to wind based electricity generation 显示文摘 | Abdullah Asuhaimi B Mohd Zin Mahmoud Pesaran H A Azhar B Khairuddin | 2013 | Renewable and Sustainable Energy Reviews2013，，27： | 1 |
| 14 | A developing world experience with distal foot amputations for diabetic limb salvage显示文摘 | Salahuddin O Azhar M Imtiaz A | 2013 | Diabet Foot Ankle2013，21，： | 1 |
| 15 | Evidence for camel-to-human transmission of MERS coronavirus 显示文摘 | Azhar E I EI-Kafrawy S A Farraj S A Hassan A M A1-Saeed M S Hashem A M Madani T A | 2014 | N Engl J Med2014，370，26： | 1 |
| 16 | Comparison of bougie-guided insertion of Proseal laryngeal mask airway with digital technique in adults显示文摘 | Kuppusamy A Azhar N | 2010 | Indian J Anaesth2010，54，1： | 1 |
| 17 | Comparison study of ammonia and COD adsorption on zeolite,activated carbon and composite materials in landfill leachate treatment显示文摘 | Azhar A Halima Hamidi A Azizb Megat Azmi Megat Joharib | 2010 | Desalination2010，17，2： | 1 |
| 18 | Effect of microsurgical varieoeeleetomy on human sperm chromatin and DNA integri- ty: a prospective trial显示文摘 | Zini A Azhar R Baazeem A | 2011 | Int J Androl2011，34，1： | 1 |
| 19 | On the measurement of product quality in intra-industry trade显示文摘 | AZHAR A K M ELLIOTT R J R | 2006 | Review of World Economics2006，142，3： | 1 |
| 20 | Building information modeling for sustainable design and LEED? rating analysis显示文摘 | Azhar S Carlton A Olsen D Ahmad I | | 0，，20： | 1 |
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