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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Conf irmation of endotracheal tube placement using disposable f iberoptic bronchoscopy in the emergent setting显示文摘BACKGROUND:Patients intubated in the prehospital setting require quick and definitive confirmation of endotracheal (ET) tube placement upon arrival to the emergency department (ED).Direct and adjunct strategies exist,but each has limitations and there is no definitive gold standard.The utility of bronchoscopy in ED intubation has been studied,but scant literature exists on its use for ET tube confirmation.This study aims to assess effectiveness,ease and speed with which ET tube placement can be confirmed with disposable fiberoptic bronchoscopy.METHODS:Emergency medicine residents recruited from a 3-year urban residency program received 5 minutes of active learning on a simulation mannequin using a disposable,flexible Ambu aScope interfaced with a monitor.With residents blinded,the researcher randomly placed the ET tube in the trachea,esophagus or right mainstem.Residents identified ET tube position by threading the bronchoscope through the tube and viewing distal anatomy.Each resident underwent 4 trials.Accuracy,speed and perceptions of difficulty were measured.RESULTS:Residents accurately identified the location of the ET tube in 88 out of 92 trials (95.7%).The median time-to-guess was 7.0 seconds,IQR (5.0-10.0).Average perceived difficulty was 1.6 on a scale from 1-5 (1 being very easy and 5 being very difficult).No tubes were damaged or dislodged.CONCLUSION:While simulation cannot completely replicate the live experience,fiberoptic bronchoscopy appears to be a quick and accurate method for ET tube confirmation.Further studies directly comparing this novel approach to established practices on actual patients are warranted. | Avir Mitra Asaf Gave Kelsey Coolahan Thomas Nguyen | 2019 | World Journal of Emergency Medicine2019，10，4： | 5 |
| 3 | Insight to drug delivery aspects for colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer diagnosed worldwide in human beings. Surgery, chemotherapy, radiotherapy and targeted therapiesare the conventional four approaches which are currently used for the treatment of CRC. The site specific delivery of chemotherapeutics to their site of action would increase effectiveness with reducing side effects. Targeted oral drug delivery systems based on polysaccharides are being investigated to target and deliver chemotherapeutic and chemopreventive agents directly to colon and rectum. Site-specific drug delivery to colon increases its concentration at the target site, and thus requires a lower dose and hence abridged side effects. Some novel therapies are also briefly discussed in article such as receptor(epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Even though good treatment options are available for CRC, the ultimate therapeutic approach is to avert the incidence of CRC. It was also found that CRCs could be prevented by diet and nutrition such as calcium, vitamin D, curcumin, quercetin and fish oil supplements. Immunotherapy and vaccination are used nowadays which are showing better results against CRC. | Arvind Gulbake Aviral Jain Ashish Jain Ankit Jain Sanjay K Jain | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 4 | Texture evaluation in AZ31/AZ31 multilayer and AZ31/AA5068 laminar composite during accumulative roll bonding显示文摘This article presents the texture development of magnesium AZ31 alloy in the accumulative roll bonded(ARB) AZ31/AZ31 multilayer and AZ31/AA5086 laminate composite.The comparative study demonstrates that the texture evolution in AZ31 in a multilayer system is strongly influenced by the interfaces.A typical basal texture of AZ31 has been observed in AZ31/AZ31 multilayer with texture intensity increased with the rolling deformation.Presence of AZ31/AA5086 interface in the laminate composite leads to a tilted basal texture along the rolling direction(RD) in AZ31 alloy.The texture intensity of composite increased initially with rolling reduction and weakened at the higher rolling strain.Weakening of texture in AZ31 during the laminate processing at higher strain has been attributed to the development of wavy interfaces in AZ31/AA5086 laminate. | Pankaj Kumar Aviral Madhup Prasad RKalvala Satyam Suwas | 2020 | Defence Technology(防务技术)2020，16，3： | 2 |
| 5 | Leaf vein segmentation using odd Gabor filtersand morphological operations显示文摘 | Vini K Aviral | 2012 | International Journal of AdvancedResearch in Computer Science2012，3，3： | 1 |
| 6 | Does financial development increase rural-urban income inequality?: Cointegration analysis in the case of Indian economy显示文摘 | Aviral Kumar Tiwari Muhammad Shahbaz Faridul Islam | 2013 | International Journal of Social Economics2013，，2： | 1 |
| 7 | Determination of Johnsow4ook Parameters from Machining Simulations显示文摘 | Aviral Shrot Martin Baker | 2012 | Computational Materials Science2012，52，： | 1 |
| 8 | Reduction of surgeryincluced peritoneal Adhesions by Methylene Bluce显示文摘 | Yair Galili Tel Avir I srael | 1998 | Am J Surg1998，175，1： | 1 |
| 9 | The environmental Kuznets curve and the role of coal consumption in India: Cointegration and causality analysis in an open economy显示文摘 | Aviral Kumar Tiwari Muhammad Shahbaz Qazi Muhammad Adnan Hye | 2013 | Renewable and Sustainable Energy Reviews2013，，： | 1 |
| 10 | A frequency domain causality investigation between futures and spot prices of Indian commodity markets 显示文摘 | Anto Joseph Garima Sisodia Aviral Kumar Tiwari | 2014 | Economic Modelling2014，，40： | 1 |
| 11 | High throughput data mapping for coarse-grained reconfigurable architecture显示文摘 | Yongjoo K Jongeun L Aviral S | 2011 | IEEE Transactions on computer-aided design of integrated circuits and systems2011，30，11： | 1 |
| 12 | Analyzing Time-frequency Relationship between Oil Price and Exchange Rate in Pakistan Through Wavelets显示文摘 | Muhammad Shahbaz Aviral Tiwari and Mohammad Iqbal Tahir | 2015 | Journal of Applied Statistics2015，，4： | 1 |
| 13 | Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests显示文摘 | Berkman Nv Aviral Av Breuer R et aJ | 2005 | Thorax2005，60，5： | 1 |
| 14 | Concanavalgin A conjuga- ted biodegradable nanoparticles for oral insulin delivery显示文摘 | Pooja H Aviral J Ashish J | 2012 | J Nanopart Res2012，14，： | 1 |
| 15 | Determination of Johnson-Cook Parameters from machining simulations显示文摘 | Aviral Shrot Martin Baker | | 0，，01： | 1 |
| 16 | Gentic transformation of cirtus protoplasts and regeneration of transgenic plants显示文摘 | Vardi A Bleichman S Avir D | 1990 | Plant science1990，69，： | 1 |
| 17 | Transferrin-appended PEGylated nanoparticles for temozolomide delivery to brain:In vitro characterization显示文摘 | Aviral Jain Gousia Chasoo Shashank KS | | 0，，01： | 1 |
| 18 | Does Financial Development In- crease Rural-Urban Income Inequality?Cointegration Analysis in The Oase of Indian Economy显示文摘 | Aviral K T Muhammad S Faridul I | 2013 | International Journal of Social Economics2013，40，2： | 1 |
| 19 | A compiler optimization to reduce soft errors in register files显示文摘 | Jongeun Lee Aviral Shrivastava | 2009 | ACM SIGPLAN Notices2009，，7： | 1 |
| 20 | Delonix regia: historic perspectives and modern phytochemical and pharmacological researches显示文摘Delonix regia(Bojer ex Hook)Raffin(Fabaceae),also known as flame of forest,is a semi-deciduous tree,distributed throughout Madagascar,India,Africa,and Northern Australia.Various parts of the plant are traditionally used for the treatment of different ailments such as inflammation,rheumatism,bronchitis,diabetes,anemia,fever,gynecological disorders,and pneumonia.The plant possess antioxidant,hepatoprotective,gastroprotective,wound healing,antiarthritic,larvicidal,antimalarial,antiemetic,antibacterial,antifungal,antiinflammatory,analgesic,antidiarrhoeal,antiheamolytic,diuretic,and anthelmintic activities.This review is an up-to-date compilation on its traditional uses in context to phytochemical and pharmacological perspectives. | Anuj Modi Vijay Mishra Ajita Bhatt Aviral Jain Mohd. Hashim Mansoori Ekta Gurnany Vimal Kumar | 2016 | Chinese Journal of Natural Medicines2016，14，1： | 0 |
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