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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Surgical management of osteonecrosis of the femoral head in patients with sickle cell disease显示文摘Sickle cell disease is a known risk factor for osteonecrosis of the hip.Necrosis within the femoral head may cause severe pain,functional limitations,and compromise quality of life in this patient population.Early stages of avascular necrosis of the hip may be managed surgically with core decompression with or without autologous bone grafting.Total hip arthroplasty is the mainstay of treatment of advanced stages of the disease in patients who have intractable pain and are medically fit to undergo the procedure.The management of hip pathology in sickle cell disease presents numerous medical and surgical challenges,and the careful perioperative management of patients is mandatory.Although there is an increased risk of medical and surgical complications in patients with sickle cell disease,total hip arthroplasty can provide substantial relief of pain and improvement of function in the appropriately selected patient. | Atul F Kamath Michael H McGraw Craig L Israelite | 2015 | World Journal of Orthopedics2015，6，10： | 2 |
| 3 | Metabo liccorrelation and manage ment strategies of non -alcoholic fatty liver disease:An Asian Indi an perspective显示文摘 | Atul L Priyanka N Anoop M | 2007 | Diabetes and Metabolic Syndrome Clinical Re search and Reviews2007，1，： | 1 |
| 4 | Application of high-frequency rheology measurements for analyzing protein-protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG2) 显示文摘 | Atul S Advait V B David L Z | 2006 | Journal of Pharmaceutical Sciences2006，95，9： | 1 |
| 5 | Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structurebased site-directed mutagenesis 显示文摘 | Patrick L Vladimir A Atul A A | 2002 | J Biol Chem2002，277，38： | 1 |
| 6 | Decision making for patients with multiple brain metastases: radiosurgery, radiotherapy, or resection?显示文摘 | Douglas K Atul P Dade L | 2000 | Neurosurg focus2000，9，2： | 1 |
| 7 | Modeling and real-time simulation architectures for virtual prototyping of off-road vehicles 显示文摘 | Karkee Manoj Steward Brian L Kelkar Atul G | 2011 | Virtual Reality2011，15，1： | 1 |
| 8 | Decision making for patients with multiple brain metastases:radiosurgery, radiotherspy, or resection 显示文摘 | Douglas K Atul P Dade L | 2000 | Neurosurg Focus2000，9，2： | 1 |
| 9 | Sleep-Disordered Breathing and COPD : The Overlap Syndrome显示文摘 | Robert L O Atul M | 2010 | RespirCare2010，55，10： | 1 |
| 10 | Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based sitedirected mutagenesis显示文摘 | Patrick L Vladimir A Atul A A | 2002 | J Biol Chem2002，277，38： | 1 |
| 11 | Modeling and real-time simulation architectures for virtual prototyping of off-road vehicles 显示文摘 | Manoj Karkee Brian L Steward Atul G Kelkar | 2011 | Virtual Reality2011，15，1： | 1 |
| 12 | Impact of gender and race on expectations and outcomes in total knee arthroplasty显示文摘BACKGROUND Total joint arthroplasty is one of the most common surgeries performed in the United States with total knee arthroplasty(TKA)being one of the most successful surgeries for restoring function and diminishing pain.Even with the demonstrated success of TKA and a higher prevalence of arthritis and arthritis related disability among minorities,racial and gender disparity remains a constant issue in providing care for the adult reconstruction patient.AIM To assess the role of demographics and expectations on differences in perioperative patient reported outcomes(PRO)following TKA.METHODS One hundred and thirty-three patients scheduled for primary unilateral TKA secondary to moderate to severe osteoarthritis were enrolled in this twoinstitution prospective study.Validated PRO questionnaires were collected at four time points.Statistical analysis was conducted to determine the impact of gender,ethnic background and expectation surveys responses to assess PRO at these time points.RESULTS Females were associated with worse preoperative Knee Injury and Osteoarthritis Outcome Scores(KOOS)for symptoms,pain,and activities of daily living.African Americans were associated with worse KOOS for pain,activities of daily living,and quality of life.Despite worse preoperative scores,no difference was noted in these categories between the groups postoperatively.Additionally,all pre-operative psychometric scales were equivalent across groups except Geriatric Depression scale,which was significantly different between groups within the Race and Age Group(P<0.05).Conversely,Pain Catastrophizing Scale,was significantly different for all subscales and total score within Age Group(P<0.05),and the Magnification,Helplessness subscales as well as the Total score were significantly different between groups for Race and Relationship Status(P<0.01).CONCLUSION We conclude that female and African American patients have lower preoperative KOOS scores compared to white male patients.No postoperative differences in outcomes between these groups. | Brian A Perez James Slover Emmanuel Edusei Annamarie Horan Afshin Anoushiravani Atul F Kamath Charles L Nelson | 2020 | World Journal of Orthopedics2020，11，5： | 0 |
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