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| 1 | 雷公藤免疫调节的体外研究显示文摘目的证实雷公藤能否选择性地抑制LPS、PHA诱导的TNFα、IFNγ的产生,以及它抑制TNFα的免疫学机理。方法采用健康供血者外周血单个核细胞(PBMC)的体外培养及ELISA,测量雷公藤甲素抑制由LPS、PHA诱导的TNFα、IFNγ的能力;通过对PBMC和单核细胞(monocyte)的预处理试验,以及其后的流式细胞仪分析,研究雷公藤抑制TNFα的免疫学机理。结果雷公藤对TNFα、IFNγ的抑制具有剂量依赖性,对TNFα的IC50为5~10ngml,对IFNγ的IC50为0.1~1.0ngml。PBMC和monocytes试验中,雷公藤的不同预处理后的TNFα浓度,与流式细胞分析产生效应的CD14+TNFα+细胞数一致。结论两种预处理方法提示了不同的临床意义。免疫表现型的分析揭示,雷公藤可能与LPS竞争结合CD14受体。该研究为雷公藤可作为抗炎剂治疗麻风反应提供了基本依据。 | 翁小满 Atkinson S Gorak-Stolinska P Dockrell H.M | 2004 | 中华微生物学和免疫学杂志2004，24，12： | 4 |
| 2 | Effect of spatial filtering on scene noise and boundary detail in Thematic Mapper imagery显示文摘 | Cushnie J L Atkinson P | 1985 | Photogrammetric Engineering and Remote Sensing1985，51，： | 2 |
| 3 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 4 | Super-resolution land cover pattern prediction using a Hopfield neural network 显示文摘 | TATEM A J LEWIS H G ATKINSON P M NIXON M S | 2002 | Remote Sensing of Environment2002，，： | 1 |
| 5 | The scholarship of teaching and learning: Reconceptualizing scholarship and transforming the academy 显示文摘 | Atkinson M P | 2001 | Social Forces2001，79，： | 1 |
| 6 | Famciclovir treatment of hepatitis B infection following liver transplantation: A long-term,multi-centre study 显示文摘 | Manns MP Neuhaus P Atkinson GF | 2001 | Transpl Infect Dis2001，3，1： | 1 |
| 7 | Phenotypic characterisation of the dendritic cell infiltrate in prostate cancer显示文摘 | Troy A Davidson P Atkinson C | 1998 | J Urol1998，160，1： | 1 |
| 8 | An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells 显示文摘 | NEGANOVA I VILELLA F ATKINSON S P | 2011 | Stem Ceils2011，29，4： | 1 |
| 9 | Fine spatialresolution simulated satellite sensor imagery for landcover mapping in the UK显示文摘 | Aplin P Atkinson P M Curran P J | 1999 | Remote Sensing ofEnvironment1999，68，3： | 1 |
| 10 | Introduction neural networks in remote sensing显示文摘 | Atkinson P Tatnall A | 1997 | International Journal of Remote Sensing1997，18，4： | 1 |
| 11 | Sub - pixel mapping of rural land cover objects from fine spatial resolution satellite sensor imagery using super-resolution pixel-swapping显示文摘 | Thornton M W Atkinson P M Holland D A | 2006 | ''International Journal of Remote Sensing2006，27，3： | 1 |
| 12 | Multiple-class land-cover mapping at the sub-pixel scale using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，2： | 1 |
| 13 | Sub-pixel land cover mappingfor per-field classification显示文摘 | Aplin P Atkinson P M | 2001 | International Journal ofRemote Sensing2001，22，14： | 1 |
| 14 | Increasing the spatial resolution of agricultural land cover maps using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2003 | International Journal of Geographical Information Science2003，17，7： | 1 |
| 15 | Multiple-class landcover mapping at the sub-pixel scale using a Hopfield neural network 显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，2： | 1 |
| 16 | Vascular calcium overload produced by vitamin D3 plus nicotine treatment diminishes arterial distensibility in rats显示文摘 | Atkinson J Poitevin P Chillon JM Lartaud I Levy B | 1994 | Am J Physiol1994，266，2： | 1 |
| 17 | Multipleclass land cover mapping at the sub-pixel scale using aHopfield neural network显示文摘 | Tatem A J Lewis H G Atkinson P M | 2001 | International Journal ofApplied Earth Observation and Geoinformation2001，3，2： | 1 |
| 18 | QPCR analysis and RNAi define pharyngeal gland cell-expressed genes of Heterodera glycines required for initial interactions with the host 显示文摘 | Bakhetia M Urwin P E Atkinson H J | 2007 | Molecular Plant- Microbe Interactions2007，20，3： | 1 |
| 19 | Exploring the Geostatistical Method for Estimating the Signal-to-Noise Ratio of Images显示文摘 | Atkinson P M Atkinson I M Sargent G M | 2007 | Photogrammetric Engineer & Remote Sensing2007，73，7： | 1 |
| 20 | Geostafistical classification for remote sensing:an introduction显示文摘 | Atkinson P M Lewis P | 2000 | Computer & Geoseiences2000，26，： | 1 |
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