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| 1 | The heat capacity and entropy, heats of fusion and vaporization, and the vapor pressure of dimethyl ether, the density of gaseous dimethyl ether 显示文摘 | Kennedy R M Sagenkahn M Aston J G | 1941 | Journal of the American Chemical Society1941，63，8： | 2 |
| 2 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 3 | Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy显示文摘Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic agents.Autophagy plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal biogenesis.Thus,small-molecule autophagy enhancers targeting TFEB hold promise for AD therapy.Here,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse brains.Importantly,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal models.Mechanistical studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to celastrol.Overall,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal models.Therefore,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies. | Chuanbin Yang Chengfu Su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang Jieqiong Tan Kingho Cheung Juxian Song Min Li | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 2 |
| 4 | Heated water farms at inland power stations显示文摘 | Aston R J Brown D J A Milner A G P | | Fish Farm Int0，3，： | 1 |
| 5 | Smoking and Parkinson's disease in twins显示文摘 | Tanner C M Goldman S M Aston D N | 2002 | Neurology2002，58，： | 1 |
| 6 | Abnomud levels of transcript abundance of developmentally important genes in various stages of preimplantation bovine somatic cell nuclear transfer embryos 显示文摘 | Aston KI Li GP Hicks BA | 2010 | Cell Repragram2010，12，1： | 1 |
| 7 | The learner's contribution to the self-access center显示文摘 | Aston G | 1993 | ELT Journal1993，47，： | 1 |
| 8 | The learner's contribution to the self-access center显示文摘 | Aston G | 1993 | ELT Journal1993，47，13： | 1 |
| 9 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，，7： | 1 |
| 10 | Long-term survival of concurrent meniscus allograft transplantation and repair of the articular cartilage:a prospective two- to 12-year fol- low-up report 显示文摘 | aStone KR Adelson WS Pelsis JR | 2010 | J Bone Joint Surg Br2010，92，7： | 1 |
| 11 | Femoral diaph- ysealendoprosthetic reconstruction after segmental re- section of primary bone tumors 显示文摘 | Hanna SA Sewell MD Aston WJ | 2010 | J Bone Joint Surg (Br)2010，92，6： | 1 |
| 12 | Pneumonia in low and middle income countries ; progress and challenges 显示文摘 | Zar H J Madhi SA Aston S J | 2013 | Thorax2013，68，11： | 1 |
| 13 | Genetic polymorphism of paraoxonase and the risk of coronary heart disease显示文摘 | Sanghera DK Saha N Aston CE | 1997 | Arterioscler Thromb Vasc Biol1997，17，10： | 1 |
| 14 | Controlled high power actuation utilizing Terfenol-D显示文摘 | Aston M G Greenough R D Jenner A G I Metheringham W J Prajapate K | 1997 | Journal of Alloys and Compounds1997，258，12： | 1 |
| 15 | Quantitative effects of the apolipoprotein E polymorphi in a biracial sample of 9-10-year-old girls显示文摘 | Sanghera DK Ferrell RE Aston CE | 1996 | Arteriosclerosis1996，126，： | 1 |
| 16 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，7，： | 1 |
| 17 | Evaluation of a tidal expiratory flow index in healthy and diseased infants 显示文摘 | Clarke JR Aston H Silverman M | 1994 | Pediatr Pulmonol1994，17，5： | 1 |
| 18 | A simple method for estimating free amino acids in Cheddar cheese显示文摘 | ASTON J W DULLEY J R | 1982 | Australian J Dairy Technol1982，37，： | 1 |
| 19 | Retrorsine in breast milk influ- ences copper handling in suckling rat pups显示文摘 | Aston N Morris P Tanner S | 1996 | J Hepatol1996，25，： | 1 |
| 20 | Preva- lence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal an- drogen excess显示文摘 | Witchel S F Kahsar-Miller M Aston C E | 2005 | Fertil Steril2005，83，2： | 1 |
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