|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Update on the management of gastrointestinal varices显示文摘Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop at sites near the formation of gastroesophageal collateral circulation. The incidence of varices is on the rise due to alcohol and obesity. The most significant complication of portal hypertension is life-threatening bleeding from gastrointestinal varices, which is associated with substantial morbidity and mortality. In addition, this can cause a significant burden on the health care facility. Gastrointestinal varices can happen in esophagus, stomach or ectopic varices. There has been considerable progress made in the understanding of the natural history, pathophysiology and etiology of portal hypertension. Despite the development of endoscopic and medical treatments, early mortality due to variceal bleeding remains high due to significant illness of the patient. Recurrent variceal bleed is common and in some cases, there is refractory variceal bleed. This article aims to provide a comprehensive review of the management of gastrointestinal varices with an emphasis on endoscopic interventions, strategies to handle refractory variceal bleed and newer endoscopic treatment modalities. Early treatment and improved endoscopic techniques can help in improving morbidity and mortality. | Umesha Boregowda Chandraprakash Umapathy Nasir Halim Madhav Desai Arpitha Nanjappa Subramanyeswara Arekapudi Thimmaiah Theethira Helen Wong Marina Roytman Shreyas Saligram | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，1： | 18 |
| 2 | Endoscopic ultrasound guided gallbladder drainage - is it ready for prime time?显示文摘Management of acute cholecystitis includes initial stabilization and antibiotics. However, the most definitive treatment is cholecystectomy. A small percentage of patients who are not suitable for surgery due to the severity of cholecystitis or comorbidities will require a temporary measure as a bridge to surgery or permanent nonoperative management to decrease the mortality and morbidity. Most of these patients who require conservative management were managed with percutaneous transhepatic cholecystostomy or trans-papillary drainage of gallbladder drainage with cystic duct stenting through endoscopic retrograde cholangiopancreaticography(ERCP). Although, these conservative measures are effective, they can cause significant discomfort to the patients especially if used as a long-term measure. In view of this, there is a need for further minimally invasive procedures, which is safe, effective and comfortable to patients. Endoscopic ultrasound(EUS) guided gallbladder drainage is a novel method of gallbladder drainage first described in 2007^([1]). Over the last decade, EUS guided gallbladder drainage has evolved as an effective alternative to percutaneous cholecystostomy and trans-papillary gallbladder drainage. Our goal is to review available literature regarding the scope of EUS guided gallbladder drainage as a viable alternative to percutaneous cholecystostomy or cystic duct stenting through ERCP among patients who are not suitable for cholecystectomy. | UmeshaBoregowda Chandraprakash Umapathy Arpitha Nanjappa Helen Wong Madhav Desai Marina Roytman Thimmaiah Theethira Shreyas Saligram | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，6： | 2 |
| 3 | A sub- set of human limbal epithelial cells with greater nucleus-to-cyto- plasm ratio expressing high levels of p63 possesses slow-cycling property 显示文摘 | Arpitha P Prajna NV Srinivasan M Muthukkaruppan V | 2008 | Cornea2008，27，10： | 1 |
| 4 | High expression of p53 combined with a large N/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stem cells显示文摘 | Arpitha P Prajna NV Srinivasan M Muthukkaruppan V | 2005 | Invest Ophthalmol Vis Sci2005，46，10： | 1 |
| 5 | Comparative study on ECG data compression methods 显示文摘 | ABHINAND1NI U ARPITHA V MADHURI C R VIJAY V | 2013 | International Journal of Innovative Research and Development2013，2，41： | 1 |
| 6 | A Subset of Human Limbal Epithelial Cells With Greater Nucleus-to-Cytoplasm Ratio Expressing High Levels of p63 Possesses Slow-Cycling Property显示文摘 | Parthasarathy Arpitha Namperumalsamy V Prajna Muthiah Srinivasan Veerappan Muthukkaruppan | 2008 | Cornea2008，，10： | 1 |
| 7 | High expression of p63 combined with a large N/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stem cells显示文摘 | Arpitha P Prajna N V Srinivasan M | 2005 | Invest Ophthaltool Vis Sci2005，46，10： | 1 |
| 8 | 星形胶质细胞中连接蛋白43在肌萎缩侧索硬化中促发运动神经元毒性显示文摘肌萎缩侧索硬化(ALS)是一种神经退行性疾病,其特征是中枢神经系统中运动神经元的进行性丧失。星形胶质细胞在ALS的疾病进程中起重要作用。星形胶质细胞通过缝隙连接蛋白家族,如连接蛋白(Connexin,Cx)互相连接。Cx43是中枢神经系统中保持稳态的主要星形胶质细胞连接蛋白。在病理状态下,连接蛋白的表达和功能发生改变。本文发现,在ALS中Cx43异常增高是星形胶质细胞介导的毒性作用机制之一。笔者观察到,在ALS SOD1^(G93A)小鼠模型的疾病进程中,Cx43表达进行性增高。尤其是,在ALS患者的运动皮质和脊髓也能检测到Cx43增高。从SOD1^(G93A)小鼠中分离的星形胶质细胞,与人诱导多能干细胞衍生的星形胶质细胞一样,都检测到Cx43蛋白增高,且为独立于神经元共培养的内源性现象。与对照的星形胶质细胞过表达的野生型SOD1(SOD1^(WT))相比,SOD1^(G93A)星形胶质细胞中增高的Cx43表达可产生重要的功能性影响。本文发现,SOD1^(G93A)星形胶质细胞表现出缝隙连接偶联增强,半通道介导活动升高,细胞内钙离子水平上升。最后,本文检测Cx43蛋白表达升高对MN生存的影响,发现应用pan-Cx43阻滞剂和Cx43半通道阻滞剂均对与SOD1^(G93A)星形胶质细胞共培养的MNs有神经保护作用。这些新发现展示出未被认知的Cx43在ALS相关的运动神经元丢失中所起作用。 | Akshata A.Almad Arpitha Doreswamy Sarah K.Gross Jean-Philippe Richard Yuqing Huo Norman Haughey Nicholas J.Maragakis 王晶 | 2016 | 神经损伤与功能重建2016，11，4： | 1 |
| 9 | High expression of p63 combined with a large N/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stem cells 显示文摘 | Arpitha P Prajna NV Srinivasan M | 2005 | Invest Ophthahnol Vis Sci2005，46，： | 1 |
| 10 | High expression of p63 combined with a large N/C ratio defines a subset of human limbal epithelial cells: implications on epithelial stern cells 显示文摘 | Arpitha P Prajna N V Srinivasan M | 2005 | Invest Ophthalmol Vis Sei2005，46，： | 1 |
| 11 | Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants显示文摘Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new therapeutics.The surface spike protein,which plays a central role in virus infection,is currently the target for vaccines and neutralizing treatments.The emergence of novel variants with multiple mutations in the spike protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein with angiotensin-converting enzyme 2(ACE2).To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody(mAb)therapies,the binding activities of the original spike protein receptor binding domain(RBD)sequence and the reported spike protein variants were investigated using surface plasmon resonance.In addition,the interactions of the ACE2 receptor,an antispike mAb(mAb1),a neutralizing mAb(mAb2),the original spike RBD sequence,and mutants D614G,N501Y,N439K,Y453F,and E484K were assessed.Compared to the original RBD,the Y453F and N501Y mutants displayed a significant increase in ACE2 binding affinity,whereas D614G had a substantial reduction in binding affinity.All mAb-RBD mutant proteins displayed a reduction in binding affinities relative to the original RBD,except for the E484K-mAb1 interaction.The potential neutralizing capability of mAb1 and mAb2 was investigated.Accordingly,mAb1 failed to inhibit the ACE2-RBD interaction while mAb2 inhibited the ACE2-RBD interactions for all RBD mutants,except mutant E484K,which only displayed partial blocking. | Deepa Raghu Pamela Hamill Arpitha Banaji Amy McLaren Yu-Ting Hsu | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 0 |
| 12 | User preference-based intelligent road route recommendation using SARSA and dynamic programming显示文摘Traffic congestion is one of the main challenges in transportation engineering. It directly impactsthe economy by increasing travel time and affecting the environment by excessive fuel consumptionand emission. Road route recommendation to overcome the congestion by alternativeroute suggestions has gained high importance. The existing route recommendation systems areproposed using the reinforcement learning algorithm (Q-learning). The techniques suggestedin this paper are state-action-reward-state-action (SARSA) algorithm and dynamic programming(DP) to guide the commuters to reach the destination with an optimal solution. The algorithmconsiders travel time, cost, flexibility, and traffic intensity as the user preference attributes torecommend an optimal route. The recommended system is implemented by building a roadnetwork graph. We assign values to each user preference attribute along the edges, which cantake high(1) or low(0) values. By considering these values, the system recommends the route.The proposed system performance is evaluated based on computation time, cumulative reward,and accuracy. The results show that DP outperforms the SARSA algorithm. | Roopa Ravish Shanta Rangaswamy Arpitha V Vasuprada U | 2023 | Journal of Control and Decision2023，10，3： | 0 |
| 13 | Couple stress nanofluid flow through a bifurcated artery—Application of catheterization process显示文摘In this article,we are exploring the hemodynamics of nanofluid,flowing through a bifurcated artery with atherosclerosis in the presence of a catheter.For treating obstruction in the artery,one can use the catheter whose outer surface is carrying the drug coated with nano-particles.The resultant solvent is considered as blood nano-fluid.Blood being a complex fluid,is modeled by couple stress fluid.In the presence of nano-particles,the temperature and the concentration distribution are understood in a bifurcated stenotic artery.The concluded mathematical model is governed by coupled non-linear equations,and are solved by using the homotopy perturbation method.Consequently,we have explored is the effects of fluid and the embedded geometric parameters on the hemodynamics characteristics.It is also realized that high wall shear stress exists for couple stress nano-fluid when compared to Newtonian nano-fluid.which is computed at a location corresponding to maximum constriction(z=12.5)of the artery. | KM Surabhi Arpitha Ravikanti D.Srikanth D.Srinivasacharya | 2021 | Applied Mathematics(A Journal of Chinese Universities)2021，36，4： | 0 |
| 14 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员