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| 1 | 采用对比基因杂交技术建立嗅神经母细胞瘤基因畸变模型显示文摘目的 建立嗅神经母细胞瘤 (ENB)的基因畸变模型并分析其特征。方法 采用对比基因杂交 (CGH)技术对 12例原发、3例复发、7例转移ENB标本进行基因检测 ,用特殊软件系统对所采集照片的荧光信号进行量化分析 ,确定肿瘤DNA与正常对照DNA之间的基因差别。结果 ENB常见DNA丢失主要见于 1p、2q、3p/q、4p/q、5p/q、6q、8p/q、9p、10p/q、11p、12q、13q、18q和 2 1q ,DNA过度表达见于 1p、7q、9q、11q、14q、16p/q、17p/q、19p/q、2 0p/q和 2 2p/q。ENB的 1p2 1 p31DNA丢失与该类肿瘤患者预后差有明显相关性。死于ENB的患者均具有以下共性 :1p2 1 p31DNA丢失、临床分期为C或D期、分化程度低 (Ⅲ或Ⅳ级 )。对 4例发生转移、复发的患者 ,将检测结果与其原发病灶基因畸变情况进行对比分析表明 ,转移、复发病灶与其原发病灶间具有高度的克隆一致性。结论 采用CGH能建立ENB的典型基因畸变模型 ,该模型有助于解释此肿瘤的生物学特性并对其预后进行评估 ,并与神经母细胞瘤、小细胞肺癌以及头颈部鳞癌进行鉴别。 | 游学俊 Iver Petersen Hartmut Arps Wolfgang Draf Ulrike Bockmhl | 2005 | 中华肿瘤杂志2005，27，1： | 2 |
| 2 | The effects of biochars from rice residue on the formation of iron plaque and the accumulation of Cd, Zn, Pb, As in rice ( Oryza sativa L.) seedlings显示文摘 | Rui-Lun Zheng Chao Cai Jian-Hong Liang Qing Huang Zheng Chen Yi-Zong Huang Hans Peter H. Arp Guo-Xin Sun | 2012 | Chemosphere2012，，7： | 2 |
| 3 | Effects of source-sink relations on photosynthetic acclimation to elevated CO2显示文摘 | Arp W J | 1991 | Plant Cell Environ1991，14，3： | 1 |
| 4 | Effects of source-sink relations on photosynthetic acclimation to elevated CO2显示文摘 | Arp W J | 1991 | Plant Cell Envir1991，14，： | 1 |
| 5 | 12 years of experience with wet oxidation显示文摘 | Andre Lalla and Rolf Arpe | 2002 | Light Metals2002，，： | 1 |
| 6 | Immunosuppression involving soluble CD83 induces tolerogenic dendritic cells that prevent cardiac al- lograft rejection 显示文摘 | Ge W Arp J Lian D | 2010 | Transplant2010，90，11： | 1 |
| 7 | Polymorphisms in the sclerosteosis/van Buchem disease gene ( SOST ) region are associated with bone-mineral density in elderly whites 显示文摘 | UITTERLINDEN AG ARP PP PAEPER BW | 2004 | Am J Hum Genet2004，75，6： | 1 |
| 8 | Credit protection and lending relationships显示文摘 | Arping S | 2014 | Journal of Financial Stability2014，10，1： | 1 |
| 9 | Analysis of Decline Curves显示文摘 | Arps J J | 1945 | Trans1945，，1945： | 1 |
| 10 | Threats to safe motherhood in Honduran Miskito communities:local perceptions of factors that contribute to maternal mortality显示文摘 | Arps S | | 0，，04： | 1 |
| 11 | Regulation of the Synthesis and Activity of AmmoniaMonooxygenase in Nitrosomonas europaea by Altering pH To Affect NH3 Availability 显示文摘 | Stein L Y Arp D J Hyman M R | 1997 | Applied and environmental microbiology1997，63，11： | 1 |
| 12 | Photosynthesis-induced biofilm calcification and calcium concentrations in phaerozoic oceans显示文摘 | Arp G Reimer A Reitner J | 2001 | Science2001，292，： | 1 |
| 13 | Myeloma with multiple rearranged immunoglobulin kappa genes:only one kappa gene codes for kappa chains显示文摘 | STORB U ARP B WILSON R | 1980 | Nucl Acids Res1980，8，20： | 1 |
| 14 | Thyrdid function in healthy and sick very - low - birth - weight infants thyrotropin and free thy- roxine levels until the sixth week of age 显示文摘 | Dembinski J Arpe V Kroll M | 2001 | BiolNeonate2001，80，3： | 1 |
| 15 | Impacts of present and future climatechange and climate variability on agriculture in the temperate re-gions: North America 显示文摘 | Moth ARP Baier W | 2005 | Clim Change2005，70，1： | 1 |
| 16 | Distribution and quantitation of plas- ma cells, T lymphocyte subsets, and B lymphocytes in bron- chus-associated lymphoid tissue of chickens: age-related differ- ences显示文摘 | Fagerland J A Arp L H | 1993 | Reg Immunol1993，5，1： | 1 |
| 17 | The subsurface telemetry problem--a practical solution显示文摘 | Arps J J Arps J L | 1964 | JPT1964，16，5： | 1 |
| 18 | Comparison of international standards for lossless still image compression 显示文摘 | Arps R B Truong T K | 1994 | Proceeding of the IEEE1994，82，6： | 1 |
| 19 | Distinct subsets of dendritic cells regulate the pattern of acute xenograft rejection and susceptibility to cyclosporine therapy显示文摘 | Wang H Arp J Huang X | 2006 | J Immunol2006，176，6： | 1 |
| 20 | Effect of surface treatments on fretting fatigue of Ti-6AI-4V 显示文摘 | GOLDEN P J HUTSON A SUNDARAM V ARPS J H | 2007 | International Journal of Fatigue2007，29，： | 1 |
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