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| 1 | Epigenetic effects of ethanol on liver and gastrointestinal injury显示文摘Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential. | Shivendra D Shukla Annayya R Aroor | 2006 | World Journal of Gastroenterology2006，12，33： | 12 |
| 2 | Association of asymptomatic otitis media with effusion in patients with adenoid hypertrophy显示文摘Objective: Clinical symptoms of otitis media with effusion are rarely brought forward to the guardians of young children who the disease is most prevalent in. This often leads to poor scholastic performances and difficult social interactions. The objective of this study was to identify asymptomatic cases of otitis media with effusion present in individuals with adenoid hypertrophy. Material and Methods: In a cross sectional study advocated in Justice K.S.Hegde Hospital, Karnataka India we evaluated one hundred patients above the age of three from August 2016 to December 2017. Candidates who presented with an adenoid nasopharyngeal ratio of more than 0.5 were selected for the study. Individuals who complained of otological symptoms were not considered for the study. Patients cleared of other pathological otological conditions were underwent audiological evaluation with pure tone audiometry and tympanometry for evaluating the middle ear status and hearing loss. Results: The study showed a total of 36% of patients evaluated presented with asymptomatic otitis media with effusion. In candidates who presented with a bilateral B tympanogram, 40% had significant conductive hearing loss of more than 25dB. Conclusion: An objective test such as impedance audiometry in all patients with adenoid hypertrophy would aid in the diagnosis of fluid in the middle ear, so that timely intervention can be done and possible complications be averted. | Vadisha Bhat Ivan Paraekulam Mani Rajeshwary Aroor Marina Saldanha M.K. Goutham Deepika Pratap | 2019 | Journal of Otology2019，14，3： | 4 |
| 3 | In vivo acute on chronic ethanol effects in liver:a mouse model exhibiting exacerbated injury,altered metabolic and epigenetic responses显示文摘 | SHUKLA S D AROOR A R RESTREPO R | 2015 | Biomolecules2015，5，4： | 1 |
| 4 | Fructose and uric Acid:is there a role in endothelial function?显示文摘 | Jia G Aroor AR Whaley-Connell AT | 2014 | Curr Hypertens Rep2014，16，6： | 1 |
| 5 | SUNCT syndrome treated witb gamma knife targeting the trigeminal nerve and sphenopalatine ganglion显示文摘 | Matbew T Srinivas D Aroor S | 2012 | J Headache Pain2012，13，49： | 1 |
| 6 | The role of tissue renin- angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endocrinol (Lausanne)2013，29，4： | 1 |
| 7 | The pathophysiology of hypertension in patients with obesity 显示文摘 | Demareo VG Aroor AR Sowers JR | 2014 | Nature Reviews Endocrinology2014，10，6： | 1 |
| 8 | Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance显示文摘 | Aroor AR Mckarns S Demarco VG | 2013 | Metabolism2013，62，11： | 1 |
| 9 | Arterial stiffness:a nexus between cardiac and renal disease显示文摘 | Jia G Aroor AR Sowers JR | 2014 | Cardiorenal Med2014，4，1： | 1 |
| 10 | Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a Mouse model of Western diet induced obesity显示文摘 | Brian Bostick Javad Habibi Lixin Ma Annayya Aroor Nathan Rehmer Melvin R. Hayden James R. Sowers | 2014 | Metabolism2014，，： | 1 |
| 11 | Ovemutrition, mTORsignaling, and cardiovascular diseases 显示文摘 | Jia G Aroor AR Martinez-Lemus LA | 2014 | Am J Physiol RegulIntegr Comp Physiol2014，307，10： | 1 |
| 12 | Cardiac insulin resistance and microRNA modulators显示文摘 | Pulakat L Aroor AR Gul R | 2012 | Exp Diabetes Res2012，2012，65： | 1 |
| 13 | Insulin resistance and heart failure : molecular mechanisms显示文摘 | Aroor AR Mandavia CH Sowers JR | 2012 | Heart Failure Clin2012，8，4： | 1 |
| 14 | Disseminated strongyloidiasis in a immunocompromised host 显示文摘 | Mundkur SC Aroor S Jayashree K | 2011 | Indian Pediatr2011，48，12： | 1 |
| 15 | Differential chan- ges in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol 显示文摘 | Aroor AR James TF Jackson DE | 2010 | Alcohol Clin Exp Res2010，34，： | 1 |
| 16 | Molecular and metabolic mechanisms of cardiac dysfunction in diabetes 显示文摘 | Mandavia CH Aroor AR Demarco VG et a/ | 2013 | Life Sci2013，92，11： | 1 |
| 17 | The role of tissue reninangiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endocrinol (Lausanne)2013，4，： | 1 |
| 18 | The pathophysiology of hypertension in patients with obesity显示文摘 | De Marco V G Aroor A R Sowers J R | 2014 | Nat Rev Endocrinol2014，10，6： | 1 |
| 19 | The role of tissue renin-angio-aldosterone system in the development of endothelial dysfunction andarterial stiffness显示文摘 | Aroor AR Demarco VG Gia G | 2013 | Frome Endocrinol( Lausanne)2013，，4： | 1 |
| 20 | The role of tissue renin - angio- tensin - aldosterone system in the development of endothelial dysfunc- tion and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endoerinol: Lausanne2013，4，： | 1 |
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