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| 1 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 2 | NCCN Clinical Practice Guidelines in Oncology: colon cancer显示文摘 | Engstrom PF Arnoletti JP Benson AR | 2009 | J Natl Com- pr Canc Netw2009，7，8： | 1 |
| 3 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd | 2009 | Natl Compr Canc Netw2009，7，： | 1 |
| 4 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 5 | Colon cancer 显示文摘 | Benson AB 3rd Arnoletti JP Bekaii-Saab T | 2011 | J NatlComprCancNetw2011，9，11： | 1 |
| 6 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 7 | NCCN clini- cal practice guidelines in oncology:colon cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 8 | Early postoperative complications of splenectomy for hematologic disease显示文摘 | Arnoletti JP Karam J Brodsky J | 1999 | Am J Clin Oncol1999，22，11： | 1 |
| 9 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer显示文摘 | Engstrom PF Arnoletti JP Benson AR | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 10 | Surgical treatment of pancreatic endocrine neoplasms显示文摘 | Fernando Gomez-Rivera Ashley E. Stewart J. Pablo Arnoletti Selwyn Vickers Kirby I. Bland Martin J. Heslin | 2007 | The American Journal of Surgery2007，，4： | 1 |
| 11 | Colon cancer显示文摘 | Benson AB 3rd Arnoletti JP Bekaii-Saab T | 2011 | J Natl Compr Canc Netw2011，9，11： | 1 |
| 12 | Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes显示文摘 | Alloatti G Arnoletti E Bassino E | | 0，，02： | 1 |
| 13 | Colon cancer显示文摘 | Benson AB Arnoletti JP Bekaii-Saab T | 2011 | J Natl Compr Canc Netw2011，9，11： | 1 |
| 14 | Obestatin affords cardioprotection to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes 显示文摘 | Alloatti G Arnoletti E Bassino E | 2010 | Am J Physiol Heart Circ Physio2010，299，2： | 1 |
| 15 | Obestatin affords cardioprotec-tion to the ischemic-reperfused isolated rat heart and inhibits apoptosis in cultures of similarly stressed cardiomyocytes显示文摘 | Alloatti G Arnoletti E Bassino E | | 0，，： | 1 |
| 16 | NCCN clinical practice guidelines in oncology:rectal cancer显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 17 | NCCN Clinical Practice Guidelines in Oncology: rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 18 | NCCN Chnical Practice Guidelines in Oncology: rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd | 2009 | J Natl Compr Canc Netw2009，7，8： | 1 |
| 19 | Colon cancer 显示文摘 | Benson AB 3rd Arnoletti JP Bekaii-Saab T | 2011 | J Natl Compr Canc Netw2011，9，11： | 1 |
| 20 | Laparoscopic and open distal pancreatecto- my, a comparison of outcomes显示文摘 | Finan K R Cannon E E Kim E J Wesley M M Arnoletti P J Heslin M J | 2009 | Am Surg2009，75，： | 1 |
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