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| 1 | Melanoma:Molecular genetics,metastasis,targeted therapies,immunotherapies,and therapeutic resistance显示文摘Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s.For some patients,early diagnosis and surgical removal of melanomas is lifesaving,while other patients typically turn to molecular targeted therapies and immunotherapies as treatment options.Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF,NRAS,and TERT genes,some of which can be therapeutically targeted.Though initially effective,many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways.Immunotherapies represent an alternative to molecular targeted therapies.However,inter-tumoral immune cell populations dictate initial therapeutic response and even tumors that responded to treatment develop resistance in the long term.As the protocol for combination therapies develop,so will our scientific understanding of the many pathways at play in the progression of melanoma.The future direction of the field may be to find a molecule that connects all of the pathways.Meanwhile,noncoding RNAs have been shown to play important roles in melanoma development and progression.Studying noncoding RNAs may help us to understand how resistance e both primary and acquired e develops;ultimately allow us to harness the true potential of current therapies.This review will cover the basic structure of the skin,the mutations and pathways responsible for transforming melanocytes into melanomas,the process by which melanomas metastasize,targeted therapeutics,and the potential that noncoding RNAs have as a prognostic and treatment tool. | William Wagstaff Rimel N.Mwamba Karina Grullon Mikhayla Armstrong Piao Zhao Bryce Hendren-Santiago Kevin H.Qin Alexander J.Li Daniel A.Hu Andrew Youssef Russell R.Reid Hue H.Luu Le Shen Tong-Chuan He Rex C.Haydon | 2022 | Genes & Diseases2022，9，6： | 2 |
| 2 | Using isokinetic dy-namometry to test ambulatory patients with multiple sclerosis显示文摘 | Armstrong LE Winant DM Swasey PR | 1983 | Phys Ther1983，63，8： | 1 |
| 3 | Dendritic atrophy in children with Down's syndrome显示文摘 | Becker LE Armstrong DL Chan F | 1986 | Ann Neurol1986，20，4： | 1 |
| 4 | Exertional heat stroke :new concepts regarding cause and care显示文摘 | Casa D J Armstrong LE Kenny GP | 2012 | Curr Sports Med Rep2012，11，3： | 1 |
| 5 | Urinary indices during dehydration, exercise, and rehydration 显示文摘 | Armstrong LE Soto JA Hacker Jr | 1998 | Sport Nutr & Exerc Metab1998，8，4： | 1 |
| 6 | Mild dehydrationimpairs cognitive performance and mood of men显示文摘 | Ganio MS Armstrong LE Casa DJ | 2011 | Br JNutr2011，106，： | 1 |
| 7 | Mild dehydrationaffects mood in healthy young women显示文摘 | Armstrong LE Ganio M Casa DJ | 2012 | J Nutr2012，142，： | 1 |
| 8 | American College of Sports Medicine position stand: exertional heat illness during training and competition 显示文摘 | Armstrong LE Casa DJ Millard- Stafford M | 2007 | Med Sci Sports Exerc2007，39，3： | 1 |
| 9 | An introduction:The role of exercise inthe etiology of exertional heatstroke显示文摘 | Hubbard R W Armstrong Le | 2001 | Med sci2001，34，： | 1 |
| 10 | Exertional heat stroke:new concepts regarding cause and care显示文摘 | Casa DJ Armstrong LE Kenny GP | 2012 | Curr Sports Med Rep2012，11，3： | 1 |
| 11 | The American foot- ball uniform: uncompensable heat stress and hyperthermic ex- haustion显示文摘 | Armstrong LE Johnson EC Casa DJ | 2010 | J Athl Train2010，45，2： | 1 |
| 12 | Hydration assessment techniques 显示文摘 | Armstrong LE | 2005 | Nutr Rev2005，63，6： | 1 |
| 13 | Endurance and resistance exercise induce muscle fiber type specific responses in androgen binding capacity显示文摘 | Deschenes M R Maresh CM Armstrong LE | 1994 | J Steroid Biochem Mol Biol1994，50，： | 1 |
| 14 | Hydration assessment techniques 显示文摘 | ARMSTRONG LE | 2005 | Nutr Rev2005，63，6： | 1 |
| 15 | Exertional Heat Stroke:New Concepts Regarding Cause and Care显示文摘 | Casa DJ Armstrong LE Kenny GP | 2012 | Curr Sports Med Rep2012，11，3： | 1 |
| 16 | Sweet syndrome and syphilis in an HIV-infected person显示文摘 | Johnson LE Armstrong AW Dezube BJ | | 0，，： | 1 |
| 17 | Exertional heat stroke: new concept regarding cause and care显示文摘 | Casa DJ Armstrong LE Kenny GP | 2012 | Curt Sports Med Rep2012，11，3： | 1 |
| 18 | Exertional heat stroke : new concepts regarding cause and care显示文摘 | Casa DJ Armstrong LE Kenny GP | 2012 | Curt Sports Med Rep2012，11，3： | 1 |
| 19 | Whole body cooling of hyperthermic runners:comparison of two field therapies 显示文摘 | Armstrong LE Crago AE Adams R | 1996 | Am J Emerg Med1996，14，4： | 1 |
| 20 | Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice显示文摘 | Poitout V Stout LE Armstrong MB | 1995 | Diabetes1995，44，3： | 1 |
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