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| 1 | Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma显示文摘Primary liver cancer is the fifth most common malignan- cy in the world and is a leading cause of cancer-related mortality.Available treatment for hepatocellular carcino- ma(HCC),the commonest primary liver cancer,is rarely curative and there is a need to develop therapy that is more effective.Specific and powerful gene silencing that can be achieved by activating RNA interference(RNAi) has generated enthusiasm for exploiting this pathway for HCC therapy.Many studies have been carried out with the aim of silencing HCC-related cellular oncogenes or the hepatocarcinogenic hepatitis B virus(HBV)and hepatitis C virus(HCV).Proof of principle studies have demonstrated promising results,and an early clinical trial assessing RNAi-based HBV therapy is currently in progress.Although the data augur well,there are several significant hurdles that need to be overcome before the goal of RNAi-based therapy for HCC is realized.Particu- larly important are the efficient and safe delivery of RNAi effecters to target malignant tissue and the limitation of unintended harmful non-specific effects. | Patrick Arbuthnot Liam Jed Thompson | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Hepatitis B virus and hepatocellular cardnoma显示文摘 | Arbuthnot P Kew M | 2001 | In J Exp Pathol2001，82，2： | 1 |
| 3 | Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways显示文摘 | Arbuthnot P Capovilla P Kew M | 2000 | J Gastroenterol Hepatol2000，15，： | 1 |
| 4 | Regulatory elements of hepatitis B virus transcription 显示文摘 | Moolla N Kew M Arbuthnot P | 2002 | J Viral Hepat2002，9，5： | 1 |
| 5 | Countering hepatitis B virus infection using RNAi:how far are we from the clinic显示文摘 | Ivacik D Ely A Arbuthnot P | | 0，，6： | 1 |
| 6 | Opportunities for treating chronic hepatitis B and C virus infection using RNA interference显示文摘 | Arbuthnot P Longshaw V Naidoo T | | 0，，8： | 1 |
| 7 | Hepatitis B virus and hepatocellular carcinoma显示文摘 | Arbuthnot P Kew M | 2001 | Int J Exp Pathol2001，82，2： | 1 |
| 8 | Hepatitis B virus and hepatocellular carcinoma显示文摘 | Arbuthnot P Kew M | 2001 | Int J Exp Pathol2001，82，： | 1 |
| 9 | Putative role of hepatitis B virus X protein in hepatocarcinogenesis:effect on apoptosis, DNA repair, mitogen-activatedprotein kinase and JAK/STAT pathways显示文摘 | Arbuthnot P Capovilla A Kew M | 2000 | J Gastroenterol Hepatol2000，15，4： | 1 |
| 10 | Hepatitis B virus and hepatocellular carcinoma显示文摘 | Kew M | 2001 | Int J Exp Pathol2001，82，： | 1 |
| 11 | Regulatory elements othepatitis B virus transcription 显示文摘 | Moolla N Kew M Arbuthnot P | 2002 | J Viral Hepat2002，9，5： | 1 |
| 12 | Remarks on the results of operative treatment of chronic constipation显示文摘 | Arbuthnot LW | 1908 | BMJ1908，1，2455： | 1 |
| 13 | Hepatitis B Virus and hepatocellular carcinoma 显示文摘 | Arbuthnot P Kew M | 2001 | International journal of experimental pathology2001，82，2： | 1 |
| 14 | RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV 显示文摘 | Barichievy S Saayman S Arbuthnot P | 2009 | Curr Top Med Chem2009，9，12： | 1 |
| 15 | A Comparison of French and American Environmental Behaviors, Knowledge and Attitudes显示文摘 | Arbuthnot J Lingg S | 1975 | International Journal of Psychology1975，10，4： | 1 |
| 16 | Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen - activated protein kinase and JAK/STAT pathways显示文摘 | Arbuthnot P Capovilla A Kew M | 2000 | J Gastroenterol Hepatol2000，15，4： | 1 |
| 17 | Hepatitis B virus and hepatocellular carcinoma显示文摘 | Arbuthnot P Kew M | | 0，，2： | 1 |
| 18 | Hepatitis B virus and hepatocellular carcinoma显示文摘 | Arbuthnot P Kew M | 2001 | Int J Exp Pathol2001，82，2： | 1 |
| 19 | Hepatitis B virus and hepatocellular carcinoma 显示文摘 | Arbuthnot P Kew M | 2001 | Int J Exp Pathol2001，82，2： | 1 |
| 20 | Hepatitis B virus and hepatocellular carci- noma 显示文摘 | Arbuthnot P Kew M | 2001 | Int J Exp Pathol2001，82，2： | 1 |
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