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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Chloride penetration into concrete in marine environment-Part II: Prediction of long term chloride penetration显示文摘 | Costa A Appleton J | 1999 | Materials and Structures1999，32，6： | 1 |
| 3 | Chloride Penetration into Concrete in Marine Environment - Part 1: Main Parameters Affecting Chloride Penetration 显示文摘 | COSTA A APPLETON J | 1999 | Materials and Structures1999，32，4： | 1 |
| 4 | 显示文摘 | APPLETON J M H TYSON J F MOUNCE R P | 1986 | Anal Chim Acta1986，179，： | 1 |
| 5 | Regional geochemical mapping in developing countries and its application to environmental studies显示文摘 | Appleton J D Ridgway J | 1993 | Applied Geochemistry1993，，2： | 1 |
| 6 | Microwave technology for energy-efficient processing of waste显示文摘 | APPLETON T J COLDER R I KINGMAN S W | 2005 | Applied Energy2005，81，1： | 1 |
| 7 | Chloride Penetration into Concrete in Marine Environment - Part 2: Prediction of Long Term Chloride Penetration 显示文摘 | COSTA A APPLETON J | 1999 | Materials and Structures1999，32，5： | 1 |
| 8 | Microwave technology for energy-efficient processing of waste显示文摘 | Appleton T J Colder R I Kingman S W | 2005 | Applied Energy2005，81，1： | 1 |
| 9 | Uncalcified ureteral stent in situ for 13 years 显示文摘 | Wood S J Tansley P D T Appleton D S | 1997 | J Urol1997，157，： | 1 |
| 10 | NMR spectra of iminobis(methylenephosphonic acid), HN(CH2PO3H2)2, and related ligands and of their complexes with platinum( Ⅱ )显示文摘 | Appleton T G Hall J R McMahon I J | 1986 | Inorg Chem1986，25，： | 1 |
| 11 | Chloride penetration into concrete in marine environment-Part I: Main parameters affecting chloride penetration显示文摘 | COSTA A Appleton J | 1999 | Materials and Structures1999，32，： | 1 |
| 12 | Chloride penetration into concrete in marine environment-Part I:Main parameters affecting chloride penetration显示文摘 | Costa A Appleton J | 1999 | Materials and Structures1999，32，6： | 1 |
| 13 | The Effect of Strenuous Exercise on mRNA Concentrations of Interleukin-12, Interferon-gamma and Interleukin-4 in Equine Pulmonary and Peripheral Blood Mononuclear Cells 显示文摘 | AINSWORTH D M APPLETON J A EICKER S W | 2003 | Vet Immunol Immunopathol2003，91，1： | 1 |
| 14 | Nuclear Safety显示文摘 | Appleton G J | 1967 | Nature1967，213，： | 1 |
| 15 | Chloride penetration into concrete in marine environment-Part II:Prediction of long term chloride penetration显示文摘 | Costa A Appleton J | 1999 | Materials and Structures1999，32，6： | 1 |
| 16 | Consensus on Trichinella spiralis antigens and antibody显示文摘 | APPLETON J A BELL R G M HOMAN W | 1991 | Parasitol Today1991，7，2： | 1 |
| 17 | Chloride penetration into concrete in marine environment-Part I:Main parameters affecting chloride penetration显示文摘 | COSTA A APPLETON J | 1999 | Materials and Structures1999，，32： | 1 |
| 18 | Chloride Penetration into Concrete in Marine Environment-PartⅡ: Prediction of long term chloride penetration显示文摘 | Appleton J | 1999 | Materials and Structures1999，32，： | 1 |
| 19 | Analyses for roll force and torque in ring rolling with some supporting experiments 显示文摘 | HAWKYARD J B JOHNSON W KIRHLAND J APPLETON E | 1973 | International Journal of Mechanical Sciences1973，15，11： | 1 |
| 20 | Microwave technology for energy-efficient processing of waste显示文摘 | Appleton T J Colder R I Kingman S W | 2005 | Applied Energy2005，81，85： | 1 |
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