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| 1 | Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle显示文摘Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric cancer.The normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(H.pylori)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant phyla.Most studies indicate that H.pylori has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the stomach.When comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of H.pylori(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains predominate.Hp-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis itself.Successful H.pylori eradication is suggested to restore gastric microbiota,at least in primary stages.It is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to unroll.Future studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by H.pylori as well as on the relationships between the gastric microbiota and gastric carcinogenesis. | Christos Liatsos Apostolis Papaefthymiou Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis Marios Giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis Kountouras | 2022 | World Journal of Gastrointestinal Oncology2022，14，5： | 6 |
| 2 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 3 | Effects of four inorganic lead compounds on the proliferation and junctional coupling of cultured REL liver cells显示文摘 | Apostoli P Huard C Chaumontet C | 2000 | Am J lnd Med2000，38，3： | 1 |
| 4 | Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation显示文摘 | Tarantini Letizia Bonzini Matteo Apostoli Pietro Pegoraro Valeria Bollati Valentina Marinelli Barbara Cantone Laura Rizzo Giovanna Hou Lifang Schwartz Joel Bertazzi Pier Alberto Baccarelli Andrea | 2009 | Environmental Health Perspectives2009，，： | 1 |
| 5 | Male reproductive toxiciy of lead in animals and humans显示文摘 | Apostoli P Kiss P Porru S | | 0，，： | 1 |
| 6 | The effect of lead on male fertility: A time to pregnancy (TTP) study 显示文摘 | Apostoli P Bellini A Porru S | 2000 | Am J Ind Med2000，38，3： | 1 |
| 7 | Exposure to metal-rich particulate matter modifies the expression of candidate micro RNAs in peripheral blood leukocytes显示文摘 | Bollati V Marinelli B Apostoli P | 2010 | Environ Health Perspect2010，118，6： | 1 |
| 8 | Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation 显示文摘 | Tarantini L Bonzini M Apostoli P | 2009 | Environ Health Perspect2009，117，2： | 1 |
| 9 | Trace dement refers,nee values in tissures frore inhabitant:, of the European community:a :tudy of 46 elements it, urine, blond and serum of Italian subjects 显示文摘 | Minnia C Sabbioni E Apostoli P | 1990 | Set Total Environ1990，95，： | 1 |
| 10 | Sperm count and chromatin structure in men exposed to inorganic lead:lowest adverse effect levels显示文摘 | Bonde JP Joffe M Apostoli P | 2002 | Occup Environ Med2002，59，4： | 1 |
| 11 | Associations between diet quality,health status and diabetic complications in patients with type 2 diabetes and comorbid obesity显示文摘 | Apostolis M Maria G.G Daphne M | | 0，，02： | 1 |
| 12 | Are current biomarkers suitable for the assessment of manganese exposure in individual workers?显示文摘 | APOSTOLI P LUCCHINI R ALESSIO L | 2000 | Am J Ind Med2000，37，3： | 1 |
| 13 | Metabolism of arsenic after acute occupational arsine intoxication 显示文摘 | Apostoli P Alessio L Romeo L | 1997 | J Toxicol Environ Health1997，52，4： | 1 |
| 14 | Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation 显示文摘 | rarantini L Bonzini M Apostoli P | 2009 | Environ Health Perspect2009，117，21： | 1 |
| 15 | Dose - response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat显示文摘 | Caroline Puel Jacinthe Mathey Apostolis Agalias | 2006 | Clin Nutr2006，25，5： | 1 |
| 16 | The role of element speciation in environmental and occupational medicine显示文摘 | Apostoli P | 1999 | Fresenius''J Anal Chem1999，363，56： | 1 |
| 17 | Are current biomarkers suitable for the assessment of manganese exposure in individual workers显示文摘 | Apostoli P Lucchini R Alessio L | 2000 | Amer J Ind Med2000，37，3： | 1 |
| 18 | Male reproductive toxicity of lead in animals and humans显示文摘 | Apostoli P Kiss P Porru S | | 0，，06： | 1 |
| 19 | Exposure to metalrich particulate matter modifies the expression of candidatemicroRNAs in peripheral blood leukocytes 显示文摘 | Bollati V Marinelli B Apostoli P | 2010 | Environ Health Perspect2010，118，6： | 1 |
| 20 | Application of pH-zone refining hydrostatic countercurrent chromatography (hCCC) for the recovery of antioxidant phenolics and the isolation of alkaloids from Siberian barberry herb显示文摘 | Wirginia Kukula-Koch Wojciech Koch Apostolis Angelis Maria Halabalaki Nektarios Aligiannis | 2016 | Food Chemistry2016，，： | 1 |
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