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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | MR imaging of bone marrow lesions:relative conspicuousness on T1-wighted,fat suppressed T2-wighted,and STIR images显示文摘 | Mirowitz SA Apicella P Rinus WR | 1994 | AJR1994，162，2： | 1 |
| 3 | The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeae显示文摘 | Ketterer M Lee FK | 1996 | J Infect Dis1996，173，3： | 1 |
| 4 | MR imaging of bone marrow lesions: relative conspicuousness on T1-weighted, fat-suppressed T2-weighted, and STIR images 显示文摘 | Mirowitz S Apicella P Reinus WR | 1994 | AJR Am J Roentgenol1994，162，1： | 1 |
| 5 | In vitro study to compare the coronal microleakage of Tempit UltraF, Tempit, IRM, and Cavit by using the fluid transport model显示文摘 | Koagel SO Mines P Apicella M | 2008 | J Endod2008，34，4： | 1 |
| 6 | Structure- property relationship in nanostructures of young and ma- ture soot in premixed flames显示文摘 | AIf4 M Apicella B Barbella R | 2009 | Proceedings the Combustion Institute2009，32，1： | 1 |
| 7 | Fusiform Gyrus responses to neutral and emotional faces in children with Autism Spectrum Disorders: a High Density ERP study 显示文摘 | Apicella F Sicca F Federico RR | 2013 | Behav Brain Res2013，8，251： | 1 |
| 8 | Evaluation of the biomechanical behavior of maxillary central incisors restored by means of endocrowns compared to a natural tooth: a 3D static linear finite elements analysis 显示文摘 | Zarone F Sorrentino R Apicella D | 2006 | Dent Mater2006，22，11： | 1 |
| 9 | Kinetic and catalytic aspects of the formation of poly( ethylene tereph- thalate) (PET) investigated with model molecules 显示文摘 | APICELLA B DI SERIO M FIOCCA L | 1998 | J App Polymer Sci1998，69，12： | 1 |
| 10 | The effect of temperature on soot properties in premixed methane flames显示文摘 | Alf M Apicella B Rouzaud J-N | 2010 | Combustion and Flame2010，157，10： | 1 |
| 11 | Cement thickness at implant-supported single-tooth Lava assemblies:a scanning electron microscopic investigation显示文摘 | Apicella D Veltri M Chieffi N | | 0，，07： | 1 |
| 12 | Extrameningeal complications of Neisseria meningitidis se-rogroup W135 infection显示文摘 | Apicella MA | 2004 | Clin Infect Dis2004，38，： | 1 |
| 13 | Fluorescence Spectroscopy of Aromatic Species Produced in Rich Premixed Ethylene Flames显示文摘 | Ciajolo A Ragucci R Apicella B | | 0，，5： | 1 |
| 14 | The effects of adhesive layer properties on stress distribution in composite restor- tions-3D finite element analysis显示文摘 | Ausiello P Apicella A Ddavidson CL | 2002 | Dent Mater2002，18，3： | 1 |
| 15 | MR imaging of bone marrow lesions: relative conspicuousness on Tl-weighted, fat sup- pressed T2-weighted, and STIR image 显示文摘 | Mirowitz SA Apicella P Reinus WR et ai | 1994 | AJR1994，162，2： | 1 |
| 16 | MR imaging of bone morrow lesions: relative conspicuousness on T1-weighted, fat suppressed T2-weighted, and STIR imaging显示文摘 | Mirowitz SA Apicella P Reinus WR | 1994 | AJR Am J Roentgenol1994，162，2： | 1 |
| 17 | Francisella tularen-sis:taxonomy,genetics,and Immunopathogenesis of a potential agent ofbiowarfare显示文摘 | MCLENDON M K APICELLA M A ALLEN L A H | 2006 | Annu Rev Microbiol2006，60，： | 1 |
| 18 | Carbon fiber post adhesion to resin luting cement in the restoration of endodontically treated teeth 显示文摘 | De Santis R Prisco D Apicella A | 2000 | Journal of Materials Science Materials in Medicine2000，11，： | 1 |
| 19 | Differential time-course of reaction time recovery depending on variations in the amplitude of a goal-directed movement after nigrostriatal lesion in monkeys显示文摘 | Apicella P Legallet E Nieoullon A | 1986 | Neurosci Lett1986，68，1： | 1 |
| 20 | Mr imaging of bonemorrow lesions: relative conspicuousness on Tl-Weighted,fat suppressed T2-weighted, and STIR imaging显示文摘 | Mirowits SA Apicella P Reinus WR | 1994 | AJR AmJ Roentgenol1994，162，2： | 1 |
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