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| 1 | Nigrostriatal alpha- synueleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson' s disease显示文摘 | Kirik D Annett LE Burger C | 2003 | Proc Natl Aead Sci U S A2003，100，5： | 1 |
| 2 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein:a new primate model of Parkinson's disease显示文摘 | Kirik D Annett LE Burger C | 2003 | Proc Natl Acad Sci USA2003，100，5： | 1 |
| 3 | Nigrostriatal alpha - synucleinopathy induced by viral vector - mediated overexpression of human alpha - synuclein : a new primate model of Parkinson 's disease 显示文摘 | Kirik D Annett LE Burger C | 2003 | Proe Natl Acad Sci USA2003，100，5： | 1 |
| 4 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein : a new primate model of Parkinson's disease 显示文摘 | KIRIK D ANNETT L E BURGER C | 2003 | Proc Natl Acad Sci U S A2003，100，28： | 1 |
| 5 | Nigrostriatal alpha-synucleinopathyinduced by viral vector-mediated overexpression of human alpha-synuclein:A new primate model of Parkinson's disease显示文摘 | Kirik D Annett L E Burger C | 2002 | Proc Natl Acad Sci USA2002，100，5： | 1 |
| 6 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease显示文摘 | Kirik D Annett LE Burger C | 2003 | Proc Natl Acad Sci USA2003，100，5： | 1 |
| 7 | Development of Passive and Active Barrier Coatings on the Basis of Inorganic–Organic Polymers显示文摘 | Sabine Amberg-Schwab Ulrike Weber Annette Burger Somchith Nique Rainer Xalter | 2006 | Monatshefte für Chemie - Chemical Monthly2006，，5： | 1 |
| 8 | Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alphasynuclein : A new primate model of Parkinson' s disease 显示文摘 | Kirik D Annett LE Burger C | 2002 | Proc Natl Aead Sci USA2002，100，： | 1 |
| 9 | Development of Passive and Active Barrier Coatings on the Basis of Inorganic-Organic Polymers 显示文摘 | Sabine Amberg-Schwab Ulrike Weber Annette Burger Somchith Nique Rainer Xalter | 2006 | Monatshefte fur Chemie-Chemlcal Monthly2006，，5： | 1 |
| 10 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-a-MSH and setmelanotide显示文摘The melanocortin-4 receptor(MC4R),a hypothalamic master regulator of energy homeostasis and appetite,is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity.Here,we present cryo-electron microscopy structures of MC4R-Gs-protein complexes with two drugs recently approved by the FDA,the peptide agonists NDP-a-MSH and setmelanotide,with 2.9 A and 2.6 A resolution.Together with signaling data from structure-derived MC4R mutants,the complex structures reveal the agonist-induced origin of transmembrane helix(TM)6-regulated receptor activation.The ligand-binding modes of NDP-a-MSH,a high-affinity linear variant of the endogenous agonist a-MSH,and setmelanotide,a cyclic anti-obesity drug with biased signaling toward Gq/11,underline the key role of TM3 in ligand-specific interactions and of calcium ion as a ligand-adaptable cofactor.The agonist-specific TM3 interplay subsequently impacts receptor-Gs-protein interfaces at intracellular loop 2,which also regulates the G-protein coupling profile of this promiscuous receptor.Finally,our structures reveal mechanistic details of MC4R activation/inhibition,and provide important insights into the regulation of the receptor signaling profile which will facilitate the development of tailored anti-obesity drugs. | Nicolas A.Heyder Gunnar Kleinau David Speck Andrea Schmidt Sarah Paisdzior Michal Szczepek Brian Bauer Anja Koch Monique Gallandi Dennis Kwiatkowski Jorg Burger Thorsten Mielke Annette G.Beck-Sickinger Peter W.Hildebrand Christian M.T.Spahn Daniel Hilger Magdalena Schacherl Heike Biebermann Tarek Hilal Peter Kuhnen Brian K.Kobilka Patrick Scheerer | 2021 | Cell Research2021，31，11： | 0 |
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