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| 1 | Management of infected pancreatic necrosis in the setting of concomitant rectal cancer:A case report and review of literature显示文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant treatment and resection for his concomitant colorectal cancer. | Kihoon Choi David E Flynn Anitha Karunairajah Andrew Hughes Ambika Bhasin Benedict Devereaux Manju D Chandrasegaram | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 2 |
| 2 | A study on defect controlled morphology of organic/inorganic composite nanofibers with different heat flow rates显示文摘 | Anitha S Thiruvadigal D J Natarajan T S | 2011 | Mate Lett2011，65，2： | 1 |
| 3 | Chitosan nanoparticles: preparation and characterization显示文摘 | Anitha R D Bioadhesive L S | 2010 | Carbohydrate Poly mers2010，81，2： | 1 |
| 4 | Feedfor- ward neural network implementation in FPGA using layer multiplexing for effective resource utilization 显示文摘 | Himavathi S Anitha D Muthuramalingam A | 2007 | IEEE Transactions on Neural Networks2007，18，3： | 1 |
| 5 | Improving stability of locking compression plates throogh a design modification: a computational investigation显示文摘 | Anitha D Das De S Sun KK | 2015 | Comput Methods Biomech Biomed Engin2015，18，2： | 1 |
| 6 | Feedforward Neural Network Implementation in FPGA Using Layer Multiplexing for Effective Resource Utilization显示文摘 | Himavathi S Anitha D Muthuramalingam A | | 0，，03： | 1 |
| 7 | Assessing bone quality in terms of bone mineral density,buckling ratio and critical fracture load显示文摘 | Anitha D Lee T | 2014 | J Bone Metab2014，21，： | 1 |
| 8 | Toxicity and immunologicalactivity of s ilver nanoparticles显示文摘 | Kiruba D Tharmaraj V Anitha ST | 2010 | Appl Clay 5cf2010，48，4： | 1 |
| 9 | Association o{ in- flammatory sialoproteins, lipid peroxides and serum magnesium levels with cardiometabolic risk factors in obese children of South Indian population 显示文摘 | Niranian G Anitha D Srinivasan AR | 2014 | Int J Biomed Sci2014，10，2： | 1 |
| 10 | Synthesis, characteri- zation, cytotoxicity and antibacterial studies of chitosan, O-car- boxymethyl and N,O-carboxymethyl chitosan nanoparticles显示文摘 | Anitha A Rani V V D Krishna R | 2009 | Carbohydrate Polymers2009，78，4： | 1 |
| 11 | Synthesis, cha-raeterization, cytotoxicity and antibacterial studies of chi- tosan, O-earboxymethyl and N, O-carboxymethyl chitosan nanoparticles显示文摘 | Anitha A Rani V V D Krishna R | 2009 | Carbohydr Polym2009，78，4： | 1 |
| 12 | Timberline change detection using topographic map and satellite imagery显示文摘 | Panigrahy S Anitha D Kimothi M M | 2010 | Tropical Ecology2010，51，1： | 1 |
| 13 | Feedforward neural network implementation in FPGA using layer multiplexing for effective resource utilization 显示文摘 | Himavathi S Anitha D Muthuramalingam A | 2007 | IEEE Transactions on Neural Networks2007，18，3： | 1 |
| 14 | Improving stability of locking compression plates through a design modification:a computational investigation显示文摘 | Anitha D Das De S Sun KK | 2015 | Comput Methods Biomech Biomed Engin2015，18，2： | 1 |
| 15 | Identification of Virulent Isolates of the Entomopathogenic Fungus Nomuraea rileyi (F) Samson for the Management of Helicoverpa armigera and Spodoptera litura 显示文摘 | Vimala D P S Prasad Y G Anitha C D | 2003 | Mycopathologia2003，156，4： | 1 |
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