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| 1 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 2 | Neuron-to-astrocyte signaling is central to the dynamic control of brain micro-circulation 显示文摘 | Zonta M Angulo M C Gobbo S | 2003 | Nat Neurosei2003，6，1： | 1 |
| 3 | Early and intermediate Amadori glycosylation adducts,oxidative stress,and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature显示文摘 | Angulo J Vallejo S Peiro C | 2003 | Diabetologia2003，46，4： | 1 |
| 4 | Influence of hydrogen on the magnetic: properties of terfenol-D显示文摘 | Ruiz D Angulo L Abell J S | 1994 | J Appl Phys1994，76，： | 1 |
| 5 | Variation in discrimi- nation factors (A15N andA13 C) :the effect of diet isotopic val- ues and appheations for diet reconstruction 显示文摘 | CAUT S ANGULO E COURCHAMP F | 2009 | Journal of Ap- plied Ecology2009，46，2： | 1 |
| 6 | Murine cytomegalovirus infection down-regulates MHC class Ⅱ expression on macrophages by induction of IL- 10 显示文摘 | Redpath S Angulo A Gascoigne N R | 1999 | J Immunol1999，162，11： | 1 |
| 7 | Visfatin impairs en-dothelium-dependent relaxation in rat and human mesen-teric microvessels through nicotinamide phosphoribosyl-transferase activity显示文摘 | Vallejo S Romacho T Angulo J | 2011 | PLoS One2011，6，27： | 1 |
| 8 | 显示文摘 | Ruiz de Angulo L Abell J S Harris I R | 1996 | J Magn Magn Mater1996，，： | 1 |
| 9 | Magnetostrictive properties of polymer bonded Terfenol-D显示文摘 | ANGULO L R ABELL J S HARRIS I R | 1996 | Journal of Mag-netism and Magnetic Materials1996，，： | 1 |
| 10 | Frequency of mesenchymal - epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide - 3 - kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer显示文摘 | GONZALEZ ANGULO A M CHEN H KARUTURI M S | 2013 | Cancer2013，119，1： | 1 |
| 11 | Atonic pupil: an unusual complication of cataract surgery 显示文摘 | Saiz A Angulo S Fernandez M | 1991 | Ophthalmic Surg1991，22，1： | 1 |
| 12 | Magnetostrictive properties of polymer bonded Terfenol-D显示文摘 | Ruiz de Angulo L Abell J S Harris I R | 1996 | Journal of Magnetism and Magnetic Materials1996，，： | 1 |
| 13 | Field measurement of soil surface hydraulic properties by disc and ring infiltrometers-a review and recent development显示文摘 | Angulo J R Vandervaere J P Roulier S | 2000 | Soil Tillage Res2000，55，12： | 1 |
| 14 | Integrating depositional models,ichnology, and sequence stratigraphy inreservoir characterization :The middle member of the Devonian-Carboniferous Bakken Formation of sub- surface southeastern Saskatchewan revisited 显示文摘 | Angulo S Buatois L A | 2012 | AAPG Bulletin2012，96，6： | 1 |
| 15 | A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis显示文摘 | Nadia Ashour Javier C. Angulo Guillermo Andrés Raúl Alelú Ana González‐Corpas María V. Toledo José M. Rodríguez‐Barbero Jose I. López Manuel Sánchez‐Chapado Santiago Ropero | 2014 | Prostate2014，，： | 1 |
| 16 | Effectiveness of high pressure balloon dilatation in the treatment of postsurgical strictures of urinary tract in children显示文摘 | Rivas S Romero R Angulo JM | 2007 | Cir Pediatr2007，20，3： | 1 |
| 17 | In vivo proton magnetic resonance spectroscopy of diseased prostate: spectroscopic features of malignant versus benign pathology显示文摘 | J.M García-Segura M Sánchez-Chapado C Ibarburen J Via?o J.C Angulo J González J.M Rodríguez-Vallejo | 1999 | Magnetic Resonance Imaging1999，，5： | 1 |
| 18 | Tadalafil Enhances the Inhibitory Effects of Tamsulosin on Neurogenic Contractions of Human Prostate and Bladder Neck显示文摘 | Javier Angulo Pedro Cuevas Argentina Fernández José M. La Fuente Antonio Allona Ignacio Moncada I?igo Sáenz de Tejada | 2012 | The Journal of Sexual Medicine2012，，9： | 1 |
| 19 | Magnetostrictive properties of polymer bonded Terfenol - D 显示文摘 | Abell J S Harris I R | 1996 | J Magn Magn Mater1996，，： | 1 |
| 20 | Murine cytomegalovirus infection down-regulates MHC class II expression on rnacrophages by induction of IL-IO 显示文摘 | Redpath S Angulo A Gascoigne NRJ | 1999 | The Journal of Immunology1999，162，： | 1 |
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