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| 1 | Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases. | Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci | 2014 | World Journal of Clinical Oncology2014，5，3： | 18 |
| 2 | Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study显示文摘AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn’s disease). Biopsy samples were taken and CD31 expression was assayed immuno- histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/f ield) compared with NBI-negative areas.CONCLUSION: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients. | Silvio Danese Gionata Fiorino Erika Angelucci Stefania Vetrano Nico Pagano Giacomo Rando Antonino Spinelli Alberto Malesci Alessandro Repici | 2010 | World Journal of Gastroenterology2010，16，19： | 9 |
| 3 | Administration of pre/probiotics with conventional drug treatment in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disease with long preclinical phase,typically followed by a slow decline in memory,thinking and reasoning abilities.The underlying pathological processes are not yet fully elucidated,although two main disease hallmarks have been associated with AD pathology:amyloid beta species and neurofibrillary tangles.The plaques are deposits of a protein fragment called beta-amyloid(Aβ),which accumulates in the spaces between neurons.Tangles are twisted fibers of the tau protein,which accumulates inside the cells. | Jakub Hort Martin Valis Francesco Angelucci | 2020 | Neural Regeneration Research2020，15，3： | 3 |
| 4 | Evaluation of metastatic potential in prostate carcinoma: an in vivo model显示文摘 | Angelucci A Gravina GL Rucci N | 2004 | Int J Oncol2004，25，6： | 1 |
| 5 | The cure of the thalassemia with bone marrow transplantation 显示文摘 | Lucarelli G Andreani M Angelucci E | 2001 | Bone Marrow Transplantat2001，28，1： | 1 |
| 6 | Reversibility of cirrhosis in patients cured of thalassentia by bone marrow transplantation显示文摘 | Muretto P Angelucci E Lucarelli G | 2002 | Ann intern Med2002，136，9： | 1 |
| 7 | Atherosclerosis:a classic inflammatory disease显示文摘 | Anogeianaki A Angelucci D Cianchetti E | | 0，，04： | 1 |
| 8 | Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders 显示文摘 | Angelucci E Barosi G Camaschella C | 2008 | Haematologica2008，93，5： | 1 |
| 9 | Prophylaxis and treatment of hepatitis B in immunocompromised patients 显示文摘 | MARZANO A ANGELUCCI E ANDREONE P | 2007 | Dig liv Dis2007，39，5： | 1 |
| 10 | BDNF in schizophrenia, depression and corresponding animal models显示文摘 | Angelucci F Brene S Mathe AA | 2005 | Mol Psychia- try2005，10，4： | 1 |
| 11 | Isolation of cancer stem cells from three human glioblastoma cell lines: characterization of two selected clones显示文摘 | Iacopino F Angelucci C Piacentini R | 2014 | PloS One2014，9，10： | 1 |
| 12 | Evaluation of metastatic potential in prostate carcinoma:an in vivo model 显示文摘 | ANGELUCCI A GRAVINA G L RUCCI N | 2004 | Int J Oncol2004，25，6： | 1 |
| 13 | Coccoid Helicobacter pylori not culturable in vitro reverts in mice显示文摘 | Cellini L Allocati N Angelucci D | | 0，，11： | 1 |
| 14 | Targeting vascular cell migration as a strategy for blocking angiogenesis:the central role of focal adhesion protein tyrosine kinase family显示文摘 | Bologna M | 2007 | Curr Pharm Des2007，13，： | 1 |
| 15 | Italian Society of Hematology practice guidelines for the management of iron overlode in thalassemia major and related disorders显示文摘 | Angelucci E Barosi G Camaschella C | 2008 | Hematologic~2008，93，： | 1 |
| 16 | Osteopontin enhances the cell proliferation induced by the epidermal growth factor in human prostate cancer cells 显示文摘 | Angelucci A Festuecia C Gravina G L | 2004 | Prostate2004，59，2： | 1 |
| 17 | BDNF in schizophrenia,depression and corresponding animal models显示文摘 | Angelucci F Brene S Mathe AA | 2005 | Mol Psychiatry2005，19，4： | 1 |
| 18 | Will new antischistosomal drugs finally emerge? 显示文摘 | Cioli D Valle C Angelucci F | 2008 | Trends Parasitol2008，24，9： | 1 |
| 19 | Roles of metalloproteases in meta- static niche 显示文摘 | Rucci N Sanitd P Angelucci A | 2011 | C urr Mol Med2011，11，8： | 1 |
| 20 | Relationship between cancer and psychology:an updated history显示文摘 | Conti C M Angelucci D Ferri M | 2011 | J Biol Regul Homeost Agents2011，25，3： | 1 |
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