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| 1 | Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR显示文摘AIM: To determine cytomegalovirus (CMV) frequency in neonatal intrahepatic cholestasis by serology, histological revision (searching for cytomegalic cells), immunohistochemistry, and polymerase chain reaction (PCR), and to verify the relationships among these methods.METHODS: The study comprised 101 non-consecutive infants submitted for hepatic biopsy between March 1982 and December 2005. Serological results were obtained from the patient's f iles and the other methods were performed on paraffin-embedded liver samples from hepatic biopsies. The following statistical measures were calculated: frequency, sensibility, specif ic positive predictive value, negative predictive value, and accuracy.RESULTS: The frequencies of positive results were as follows: serology, 7/64 (11%); histological revision, 0/84; immunohistochemistry, 1/44 (2%), and PCR, 6/77 (8%). Only one patient had positive immunohistochemical fi ndings and a positive PCR. The following statistical measures were calculated between PCR and serology: sensitivity, 33.3%; specificity, 88.89%; positive predictive value, 28.57%; negative predictive value, 90.91%; and accuracy, 82.35%. CONCLUSION: The frequency of positive CMV varied among the tests. Serology presented the highest positive frequency. When compared to PCR, the sensitivity and positive predictive value of serology were low. | Maria Angela Bellomo-Brandao Paula D Andrade Sandra CB Costa Cecilia AF Escanhoela Jose Vassallo Gilda Porta Adriana MA De Tommaso Gabriel Hessel | 2009 | World Journal of Gastroenterology2009，15，27： | 8 |
| 2 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 3 | Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation显示文摘AIM To analyze whether fluid overload is an independent risk factor of adverse outcomes after liver transplantation(LT).METHODS One hundred and twenty-one patients submitted to LT were retrospectively evaluated.Data regarding perioperative and postoperative variables previously associated with adverse outcomes after LT were reviewed.Cumulative fluid balance(FB) in the first 12 h and 4 d after surgery were compared with major adverse outcomes after LT.RESULTS Most of the patients were submitted to a liberal approach of fluid administration with a mean cumulative FBover 5 L and 10 L,respectively,in the first 12 h and 4 d after LT.Cumulative FB in 4 d was independently associated with occurrence of both AKI and requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated with AKI and RRT were,respectively,male sex and Acute Physiology and Chronic Health Disease Classification System(APACHE II) levels and sepsis or septic shock.Mortality was shown to be independently related to AST and APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and 2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the degree of graft dysfunction and severity of early postoperative course of LT.No effect of FB on mortality after LT was disclosed.CONCLUSION Cumulative positive FB over 4 d after LT is independently associated with the development of AKI and the requirement of RRT.Survival was not independently related to FB,but to surrogate markers of graft dysfunction and severity of postoperative course of LT. | Liana Codes Ygor Gomes de Souza Ricardo Azevedo Cruz D'Oliveira Jorge Luiz Andrade Bastos Paulo Lisboa Bittencourt | 2018 | World Journal of Transplantation2018，8，2： | 4 |
| 4 | New charge-carrier blocking materials for high efficiency OLEDs显示文摘 | Vadim I. Adamovich Steven R. Cordero Peter I. Djurovich Arnold Tamayo Mark E. Thompson Brian W. D’Andrade Stephen R. Forrest | 2003 | Organic Electronics2003，，2： | 2 |
| 5 | Remote fiber-optic biosensors based on evanescent-excited fluoro-immunoassay:Concept and progress 显示文摘 | Andrade J D Vanwagenen R A Gregonis D E | 1985 | IEEE Transactions on Electron Devices1985，32，7： | 1 |
| 6 | Incorporation of V, Zn and Pb into the crystalline phases of Portland clinker 显示文摘 | ANDRADE F R D MARINGOLO V KIHARA Y | 2003 | Cem Concr Res2003，33，1： | 1 |
| 7 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 8 | Syngas production in downdraft biomass gasifiers and its application using internal combustion engines显示文摘 | Martinez J D Mahkamov K Andrade R V | 2012 | Renewable Energy2012，38，7： | 1 |
| 9 | Effects of tillage method and crop rotation on the population sizes and diversity of bradyrhizobia nodulating soybean显示文摘 | FERREIRA M C ANDRADE D S CHUEIRE L M O | 2000 | Soil Biology Biochemistry2000，32，： | 1 |
| 10 | White Light Emission Using Excimers in Electrophosphorescent Organic Light-Emitting Devices显示文摘 | BRIAN W D'ANDRADE JASON BROOKS VADIM ADAMOVICH | 2002 | Adv Mater2002，14，15： | 1 |
| 11 | Arbutin-2'-sulphonyl from the infusion of llex theezans leaves 显示文摘 | ANDRADE F D P PIACENTE S PIZZA C | 2004 | Fitoterapia2004，，78： | 1 |
| 12 | Probing surface microheterogeneity of poly (ether urethanes) in an aqueous environment显示文摘 | TINGEY K G ANDRADE J D | 1991 | Langmuir1991，7，： | 1 |
| 13 | Leaf expansion, photosynthesis, and water relations of sunflower plants growth on compacted soil 显示文摘 | Andrade A Wolf D W Fereres E | 1993 | Plant and Soil1993，149，2： | 1 |
| 14 | Potentiostatic determination of chloride threshold values for rebar depassivation experimental and statistical study显示文摘 | Izquierdo D Alonso C Andrade C | 2004 | Electrochimical methods in corrosion research2004，49，17： | 1 |
| 15 | An improved har- mony search algorithm for synchronization of discrete-time chaotic systems 显示文摘 | Santos Coelho L d de Andrade Bernert D L | 2009 | Chaos Solitons and Fractals2009，41，15： | 1 |
| 16 | Thoracoscopic ver- sus thoracotomy approaches to lobectomy: differential impairment of cellular immunity 显示文摘 | Whitson BA D'Cunha J Andrade RS | 2008 | The Annals of thoracic surgery2008，86，6： | 1 |
| 17 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 18 | Catalytic Effect of Magnetic Nanoparticles Over the H202 Decomposition Reaction显示文摘 | Andrade A L Souza D M Pereira M C | 2009 | J NanosciNanotechnol2009，9，5： | 1 |
| 19 | The coherent frequency in the electroencephalogram as an objective measure of cognitive function durin g propofol sedation显示文摘 | Andrade J Sapsford DJ Jeevaratnum D | 1996 | Anesth Analg1996，83，6： | 1 |
| 20 | Potentiostatic determination of chloride threshold values for rebar depassivation: Experimental and statistical study 显示文摘 | Izquierdo D Alonso C Andrade C | 2004 | Electrochimica Acta2004，49，1718： | 1 |
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